Comparison of Anterior Segment Structures in Two Rat Glaucoma Models: An Ultrasound Biomicroscopic Study

Abstract

Despite apparently higher IOP exposure, eyes in the EVC rat model of glaucoma do not undergo changes in the AC. In contrast, eyes subjected to HSEVS display deepening of the AC and reduction in size of the ciliary body within 5 to 6 weeks. These changes correlate to IOP exposure and may be the result of specific changes induced by the experimental intervention. These models are likely to rely on different mechanisms of pressure elevation and cannot be used interchangeably.

Morphometric Changes in the Rat Optic Nerve Following Short-term Intermittent Elevations in Intraocular Pressure

“…That IOP returned to baseline levels even at the end of the 6-week trial further supports the lack of synechiae in this model. Unlike other models, 22,25,29 inflammation was not noted in the anterior chamber (Fig. 4).…”

Circadian rhythm of intraocular pressure in the adult rat

“…It has become standard practice to house the rats used in these experiments in constant light (Ahmed et al, 2004; Hartwick et al, 2005; Jia et al, 2000; Nissirios et al, 2008; Pang et al, 2005; Sposato et al, 2009). With the assumption that there is negligible daily variation in intraocular pressure under these conditions, the advantage of this approach is that a single measurement was thought to provide a reasonable estimate of the cumulative pressure exposure for that day.…”

The Microbead Occlusion Model: A Paradigm for Induced Ocular Hypertension in Rats and Mice

“…5 Briefly, episcleral vein injection of hypertonic saline elevates IOP by altering aqueous outflow through sclerosis. 7,8 This elevation persists as long as 200 days but varies dramatically in magnitude between individual animals. 5,7,9 Laser photocoagulation of either the trabecular meshwork alone or in concert with episcleral veins elevates IOP for far shorter durations: Ͻ21 days in the rat 10,11 and 6 weeks in the mouse.…”