Comparison of antagonist mild and long agonist protocols in terms of follicular fluid total antioxidant capacity

Mathyk, Begüm Aydoğan; Çetin, Berna Aslan; Vardagli, Duygu; Zengin, Emel; Sofiyeva, Nigar; İrez, Tülay; Öçal, Pelin

doi:10.1016/j.tjog.2018.02.005

Cited by 9 publications

(6 citation statements)

References 24 publications

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“…These are produced by phagocytic macrophages, parenchymal and endothelial cells. This physiological situation is counter arrested by an antioxidant defense system, which prevents oxidative stress (ovarian redox homeostasis); however, the antioxidant response is usually variable depending on several factors ( Aydogan Mathyk et al , 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Oxidative balance in follicular fluid of ART patients of advanced maternal age and blastocyst formation

Pella¹,

Suárez-Cunza²,

Orihuela³

et al. 2020

JBRA Assisted Reproduction

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Objective: To evaluate the follicular fluid oxidative balance of infertile patients of advanced-maternal-age and the correlation between oxidative imbalance in the follicular fluid and the embryological outcomes. Methods: Follicular fluid (FF) from infertile patients of advanced-maternal-age undergoing ART treatments were collected and frozen in cryovials at -86°C until further use, and analyzed at the Biochemistry and Nutrition Institute of San Marcos University. As controls, we used FF from oocyte donors. The FF was then assayed for oxidative balance by ABTS, FRAP and TBARS assays. In order to establish the correlation between oxidative balance and embryo quality, we correlated the number of usable blastocysts (freshly transferred or frozen blastocysts) with the results from ABTS, FRAP and TBARS. Results: Follicular fluid from patients of Advanced-maternal-age (AMA group) significantly differed from the values found in the control group; the ABTS value was higher and the FRAP value was lower, in comparison to the FF from oocyte donors (control group). The lipid peroxidation was not different between those two groups. Furthermore, there was no significant correlation among the results of the assays, or when correlated with the proportion of usable blastocysts. Conclusion: Ovarian oxidative balance seems to be critical for oocyte quality in advanced-maternal-age patients; however, we still need more studies on oxidative stress indicators, on a larger set of patients.

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Section: Discussionmentioning

confidence: 99%

Oxidative balance in follicular fluid of ART patients of advanced maternal age and blastocyst formation

Pella¹,

Suárez-Cunza²,

Orihuela³

et al. 2020

JBRA Assisted Reproduction

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“…As shown in Table 3, this corresponds with studies by Jamil et al 16 (0.85 ± 1.07 vs 1.62 ± 2.29) who showed a correlation between low maternal AMH and development of preeclampsia. Mathyk et al 12 (0.79 ± 0.40 ng/mL vs 1.45 ± 0.93 ng/mL) found statistically significant correlation (p = 0.01). In a study by Tokmak et al 9 (0.62 ± 0.51 vs 0.93 ± 0.83 ng/mL), the sensitivity of AMH as predictor of preeclampsia was 67.4% and specificity was 47.7%.…”

Section: Discussionmentioning

confidence: 83%

“…9,10 Some researchers discovered that biomarker serum AMH levels in prenatal preeclamptic women were found to be lower than in normal blood pressure women at 11-14 weeks of gestation. [8][9][10][11] Whereas some studies showed no association 12,13 between AMH and emergence of preeclampsia. Preeclampsia is intricate, and till date no clinically useful test can be applied to predict preeclampsia.…”

Section: Introductionmentioning

confidence: 99%

Maternal Serum Anti-Müllerian Hormone Levels as Predictor of Preeclampsia

Bhalerao,

Pajai

2023

Journal of South Asian Federation of Obstetrics and Gynaecology

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Aim:This study aims at finding the association of serum anti-Müllerian hormone (AMH) levels at 11-14 weeks of gestation in the prediction of preeclampsia. Materials and methods: Antenatal patients between 11 and 14 weeks of gestation were recruited after providing written informed consent. Serum AMH was done for all patients. They were then categorized into the low AMH group and the normal AMH group. They were followed for the development of preeclampsia till 7 days postpartum and the pregnancy outcomes of both groups were compared. Conclusion:The occurrence of preeclampsia in patients with normal AMH levels was low accounting for 34.4% compared to patients with low AMH levels where preeclampsia was 65.6%. The occurrence of preeclampsia at a tertiary care hospital was 16.6%. The frequency of preeclampsia in patients with low AMH was 9 times higher than normal AMH levels. Thus, low AMH levels at 11-14 weeks can predict preeclampsia so should be incorporated into first-trimester screening. Clinical significance: Biomarker maternal serum AMH has recently been related to preeclampsia and its connection with the placenta and heart muscle would suggest its role in preeclampsia and cardiovascular risk later in the life of women with low AMH levels.

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“…The difference in study outcomes may be explained by differences in IVF procedures and patient characteristics. In MNC-IVF, the patient’s natural ovulatory cycles are followed, hence a much lower dose of gonadotropins is administered which is likely to influence the FF total antioxidant capacity 33 . The lower doses of exogenous hormones result in the development of only one dominant follicle.…”

Section: Discussionmentioning

confidence: 99%

Anti-oxidative function of follicular fluid HDL and outcomes of modified natural cycle-IVF

Nagy

Montfoort

Groen

et al. 2019

Sci Rep

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High density lipoproteins (HDL) are the main cholesterol carriers in follicular fluid (FF), the natural environment of oocyte development. Additionally, HDL have critical biological functions such as anti-oxidative capacity, which have not been studied in reproduction. Therefore, this study aimed to investigate whether the anti-oxidative function of FF-HDL is associated with fertility outcomes. From 253 women undergoing modified natural cycle (MNC)- IVF at a single academic centre FF and plasma were collected (n = 375 cycles). Anti-oxidative function of FF was mainly attributable to HDL (n = 8; 83%). FF-HDL had a higher anti-oxidative function than plasma HDL (n = 19, P < 0.001) coinciding with increased vitamin E and sphingosine 1 phosphate content (P = 0.028 each). Proteomic analysis indicated no significant differences in major anti-oxidative proteins such as paraoxonase 1, apolipoprotein (apo) A-I or apoA-IV between FF-HDL and matched plasma-HDL (n = 5), while apoC-III, apoE and apoC-II were relatively lower in FF-HDL. Finally, FF-HDL anti-oxidative function was related to a decrease in the odds of the oocyte undergoing normal fertilization, an association that persisted after adjustment for confounders (odds ratio 0.97 (0.93–1), P = 0.041). In conclusion, FF-HDL has considerable anti-oxidative properties that might be relevant for embryo quality.

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Comparison of antagonist mild and long agonist protocols in terms of follicular fluid total antioxidant capacity

Cited by 9 publications

References 24 publications

Oxidative balance in follicular fluid of ART patients of advanced maternal age and blastocyst formation

Oxidative balance in follicular fluid of ART patients of advanced maternal age and blastocyst formation

Maternal Serum Anti-Müllerian Hormone Levels as Predictor of Preeclampsia

Anti-oxidative function of follicular fluid HDL and outcomes of modified natural cycle-IVF

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