Comparison of Anesthetic Efficacy of Lidocaine and Bupivacaine in Spinal Anesthesia in Chickens

Khamisabadi, Ali; Kazemi‐Darabadi, Siamak; Akbari, Ghasem

doi:10.1647/1082-6742-35.1.60

Cited by 8 publications

(7 citation statements)

References 30 publications

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“…However, the time of onset of action and the duration of action are not defined for birds [54]. In the present study, lidocaine was used because it has a rapid onset of action in mammals [56], as well as a short onset of action for spinal anesthesia in chickens [58]. Given that higher sensitivity to local anesthetics is expected in birds than in mammals [59], embryos were intensively monitored for the occurrence of toxic effects.…”

Section: Discussionmentioning

confidence: 99%

Nociception in Chicken Embryos, Part I: Analysis of Cardiovascular Responses to a Mechanical Noxious Stimulus

Weiss,

Saller,

Werner

et al. 2023

Animals

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Although it is assumed that chicken embryos acquire the capacity for nociception while developing in the egg, an exact time point has not yet been specified. The present research was an exploratory study aiming to determine when the capacity of nociception emerges during embryonic development in chickens. Changes in blood pressure and heart rate (HR) in response to a noxious mechanical stimulus at the base of the beak versus a light touch on the beak were examined in chicken embryos between embryonic days (EDs) 7 and 18. Mean arterial pressure (MAP) was the most sensitive parameter for assessing cardiovascular responses. Significant changes in MAP in response to a noxious stimulus were detected in embryos at ED16 to ED18, whereas significant changes in HR were observed at ED17 and ED18. Infiltration anesthesia with the local anesthetic lidocaine significantly reduced the response of MAP on ED18, so the measured cardiovascular changes may be interpreted as nociceptive responses.

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Section: Discussionmentioning

confidence: 99%

Nociception in Chicken Embryos, Part I: Analysis of Cardiovascular Responses to a Mechanical Noxious Stimulus

Weiss,

Saller,

Werner

et al. 2023

Animals

View full text Add to dashboard Cite

show abstract

“…However, the �me of onset of ac�on and the dura�on of ac�on are not defined for birds 51 . In the present study, lidocaine was used because it has a rapid onset of ac�on in mammals 53 , and in chicken, a short onset of ac�on has also been described in spinal anesthesia 55 . Given that higher sensi�vity to local anesthe�cs is expected in birds than in mammals 56 , embryos were intensively monitored for the occurrence of toxic effects.…”

Section: Discussionmentioning

confidence: 99%

Nociception in chicken embryos, Part I: Analysis of cardiovascular responses to a mechanical noxious stimulus

Weiss

Saller

Werner

et al. 2023

Preprint

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While it is assumed that chicken embryos acquire the ability for nociception during the developmental period in the egg, an exact time point has not yet been specified. This study aimed to determine the onset of nociception during embryonic development in chicken. Changes in blood pressure and heart rate (HR) in response to a mechanical noxious stimulus at the base of the beak versus a light touch on the beak in chicken embryos between embryonic days (EDs) 7 and 18 were examined. Mean arterial pressure (MAP) was the most sensitive parameter for assessing cardiovascular responses. Significant changes in MAP in response to a noxious stimulus were detected in embryos at ED16 to ED18, while significant changes in HR were observed on ED17 and ED18. Infiltration anesthesia with the local anesthetic lidocaine significantly reduced reactions in MAP on ED18, so the cardiovascular changes can be assumed to be nociceptive responses.

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“…However, in the manual observations, application of lidocaine reduced the percentage of embryos that responded to stimuli with Wide Beak Opening and Beak Opening by about half. Furthermore, local anesthetics are known to be effective in birds [35][36][37] and can be used in chickens, e.g., for spinal anesthesia 38 or a brachial plexus blockade 39 . However, there are no reliable empirical data regarding the mode of action of local anesthetics in chicken embryos.…”

Section: Discussionmentioning

confidence: 99%

Nociception in chicken embryos, Part III: Analysis of movements before and after application of a noxious stimulus

Suess

Werner

Saller

et al. 2023

Preprint

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Many potentially noxious interventions are performed on chicken embryos in research and in the poultry industry. It is therefore essential and in the interest of animal welfare to be able to precisely define the point at which a chicken embryo is capable of nociception in ovo. The present part III of a comprehensive study examined the movements of developing chicken embryos with the aim of identifying behavioral responses to a noxious stimulus. For this purpose, a noxious mechanical stimulus and a control stimulus were applied in a randomized order. The recorded movements of the embryos were evaluated using the markerless pose estimation software DeepLabCut and manual observations. After the application of the mechanical stimulus, a significant increase in beak movement was identified in 15- to 18-day-old embryos. In younger embryos, no behavioral changes related to the noxious stimulus were observed. The presented results results indicate that noxious mechanical stimuli at the beak base evoke a nocifensive reaction in chicken embryos starting at embryonic day 15.

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Comparison of Anesthetic Efficacy of Lidocaine and Bupivacaine in Spinal Anesthesia in Chickens

Cited by 8 publications

References 30 publications

Nociception in Chicken Embryos, Part I: Analysis of Cardiovascular Responses to a Mechanical Noxious Stimulus

Nociception in Chicken Embryos, Part I: Analysis of Cardiovascular Responses to a Mechanical Noxious Stimulus

Nociception in chicken embryos, Part I: Analysis of cardiovascular responses to a mechanical noxious stimulus

Nociception in chicken embryos, Part III: Analysis of movements before and after application of a noxious stimulus

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