Background: Laryngeal mask airway (LMA) anesthesia with nerve block seems a promising alternative to traditional general anesthesia with endotracheal intubation (ETI), and was applied in kinds of surgeries but not in rib fracture surgery. We developed a protocol for LMA anesthesia technique and evaluated its feasibility for internal fixation of rib fractures. Methods: Twenty patients undergoing unilateral rib fracture surgery were enrolled. Thoracic paravertebral block(TPB) and/or erector spinae plane block(ESPB) were performed before LMA anesthesia. Heart rate (HR), blood pressure (BP), pulse oximetry (SpO 2 ) and respiratory parameters were measured. Arterial blood gas analysis and chest X-ray were performed preoperatively and on the day after the operation. All patients received postoperative continuous analgesia (PCA) with 500mg of tramadol and 16mg of lornoxicam, and intravenous 50mg flurbiprofen twice a day. The numerical rating scale (NRS) pain score at 6(T1), 12(T2), 24(T3) hours after surgery and postoperative nausea and vomiting(PONV) within 48 h after surgery were assessed as well. We also recorded the incidence of perioperative reflux, aspiration, and nerve block related complications. Results: Thirteen men and 7 women (age 35-70 years) were enrolled. Six (30%) had a flail chest, 9 (45%) had haemothorax and/or pneumothorax, and 2 (10%) had pulmonary contusions. Vital signs and spontaneous breathing were stable during the surgery. End-tidal carbon dioxide concentrations(EtCO 2 ) were within an acceptable range (≤ 63mmHg in all cases). The postoperative partial pressure of arterial oxygen (PaO 2 ) was higher than the preoperative value (91.2±16.0 vs. 83.7±15.9 mmHg, p =0.004). The preoperative and postoperative partial pressure of arterial carbon dioxide(PaCO 2 ) were 42.1±3.7 and 43.2±3.7mmHg ( p =0.165), respectively. NRS at T1, T2, and T3 were 3±1, 2±2, and 0, respectively. None suffered from PONV, regurgitation, aspiration and nerve block related complications. Conclusions: The technique of laryngeal mask anesthesia combined with nerve block was feasible for internal fixation of rib fractures.