Comparison of analgesic effect of direct breastfeeding, oral 25% dextrose solution and placebo during 1st DPT vaccination in healthy term infants: A randomized, placebo controlled trial

Abstract

Direct breastfeeding and 25% dextrose act as analgesic in young infants undergoing DPT vaccination in young infants less than 3 month of age.

Pharmacological and Combined Interventions to Reduce Vaccine Injection Pain in Children and Adults

“…In all studies, breastfeeding was commenced immediately before vaccination and continued during and afterward. In the included trials, the comparator arm varied from the infant being swaddled in the bassinet/placed on the table 24 , 26 held in the mother’s arms, 27 , 29 restrained by the mother, 22 given distilled water 25 to a no intervention roup. 23 , 30 , 33…”

“…The SMD was −1.78 (CI, −2.35, −1.22) for acute distress (n=792; data from 8 studies). 22 , 23 , 25 – 27 , 29 , 30 , 33 For distress during the acute plus recovery phase (n=424) the SMD was −1.89 (CI, −3.19, −0.59). Considerable heterogeneity was reported for this outcome, which can be explained by the potential differences in the implementation of the intervention (breastfeeding and the control group) and age of the infant (studies included infants less than 24 h of age to up to 12 mo).…”

Assessment of pain in newborns during immunization by using a scoring system

“…U studiji Gosvamija i saradnika ispitivana je efikasnost nefarmakološke analgezije tokom imunizacije odojčadi. Zaključak ove studije je bio da prirodna ishrana i oralna primena 25% rastvora glukoze deluje kao analgetik tokom imunizacije odojčadi (21).…”

Efeito da combinação da amamentação e contato pele-a-pele na dor induzida pela vacina BCG em recém-nascidos a termo: ensaio clínico randomizado

“…Em relação à duração do choro, houve diferenças estatísticas significativas a favor do grupo caso 27,37 segundos (DP 44,12) e controle 46,00 segundos (DP 39,51), p < 0,001 e após a vacina, caso 6,00 segundos (DP 32,86) e controle, 17,43 segundos (DP46,27), p = 0,008. As médias da SatO 2 durante a vacina foram, caso 96,17% (DP 2,61) e controle 94,53% (DP 2,64), p = 0,100 (Saeidi et al, 2011 (Codipietro, Ceccarelli, Ponzone, 2008;Goswami et al, 2013) ou 60 minutos (Gabriel et al, 2013).…”

“…Os estudos sobre dor em RN a termo disponíveis na literatura não consideraram essa variável (Carbajal et al, 2003;Codipietro, Ceccarelli, Ponzone, 2008;Gabriel et al, 2013;Goswami et al, 2013;Iqbal et al, 2014;Modarres et al, 2013) diferentemente, daqueles realizados com pré-termos, já que estes comumente necessitam de mais intervenções (Gibbins et al, 2002;Olsson, Ahlsén, Eriksson, 2016).…”