Comparison of Amnio‐Exchange With a Novel Synthetic Amniotic Fluid Versus Commercially Used Fluids for Fetal Therapy: An In Vivo Rodent Model
Samuel Martin,
Jose L. Peiro,
Marc Oria
et al.
Abstract:ObjectiveNormal Saline (NS) and Lactated Ringer's (LR) damage human amniotic epithelium in vitro when compared with a synthetic amniotic fluid (Amnio‐well, AW). We sought to evaluate the effect of amnio‐exchange with NS, LR, and AW in vivo.MethodsOn day E17.5, pregnant rats underwent amnio‐exchange with NS, LR, or AW. Fetuses in each pregnant rat that did not undergo amnio‐exchange acted as controls. Amnions were harvested at E20.5 and ultrastructure evaluated via electron microscopy. Protein levels of cleaved… Show more
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