Comparison of amnesias induced by electroconvulsive shock administered after training-trial footshock or noncontingent footshock in rats.

DeVietti, Terry L.; Holliday, Justin H.; Larson, Raymond C.

doi:10.1037/h0034859

Cited by 14 publications

(11 citation statements)

References 26 publications

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“…For example, memory reactivation through the re-experience of a single contingent-reinforcing stimulus given in the same context as previous intermediate-term memory training boosts a residual memory trace into long-term memory (Parvez et al, 2006). Electrical stimulation of the mesencephalic reticular formation (MRF) improves the retention of memories, including fear conditioning and linear maze, when the stimulus is applied after reactivation (DeVietti et al, 1973; Sara, 2000a). During the reconsolidation phase, memory retention can be increased by pharmacological modulation (Frenkel et al, 2005; Tronson et al, 2006), suggesting that after reactivation memory can be strengthened.…”

Section: The Functions Of Memory Reconsolidationmentioning

confidence: 99%

The Role of Reconsolidation and the Dynamic Process of Long-Term Memory Formation and Storage

Alberini¹

2011

Front. Behav. Neurosci.

228

186

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It is becoming increasingly clear that the processes of memory formation and storage are exquisitely dynamic. Elucidating the nature and temporal evolution of the biological changes that accompany encoding, storage, and retrieval is key to understand memory formation. For explicit or medial temporal lobe-dependent memories that form after a discrete event and are stored for a long time, the physical changes underlying the encoding and processing of the information (memory trace or engram) remain in a fragile state for some time. However, over time, the new memory becomes increasingly resistant to disruption until it is consolidated. Retrieval or reactivation of an apparently consolidated memory can render the memory labile again, and reconsolidation is the process that occurs to mediate its restabilization. Reconsolidation also evolves with the age of the memory: Young memories are sensitive to post-reactivation disruption, but older memories are more resistant. Why does a memory become labile again if it is retrieved or reactivated? Here I suggest that the main function of reconsolidation is to contribute to the lingering consolidation process and mediate memory strengthening. I also discuss the literature and results regarding the influence of the passage of time on the reconsolidation of memory. These points have important implications for the use of reconsolidation in therapeutic settings.

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Section: The Functions Of Memory Reconsolidationmentioning

confidence: 99%

The Role of Reconsolidation and the Dynamic Process of Long-Term Memory Formation and Storage

Alberini¹

2011

Front. Behav. Neurosci.

228

186

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“…However, supporting evidence include, for example, a recent finding by Parvez et al [50] showing that memory reactivation through the reexperience of a single contingent-reinforcing stimulus given in the same context as previous intermediate-term memory training boosts a residual memory trace into long-term memory. In addition, electrical stimulation of the mesencephalic reticular formation (MRF) improves the retention of memories, including fear conditioning and linear maze, when the stimulus is applied after reactivation [13,51]. Finally, clear evidence has recently shown that during the reconsolidation phase memory retention can be increased by pharmacological modulation [52,53], suggesting that after reactivation memory can be strengthened.…”

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confidence: 99%

Reconsolidation: the samsara of memory consolidation

Alberini

2007

Debates in Neuroscience

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Memory formation is a complex and very dynamic process. After a learning event, the acquired information undergoes a number of changes that eventually result in memory storage. Stored memories are very malleable. Recent rediscoveries show that after reactivation, for example by retrieval, an established memory can become transiently sensitive to disruption and needs to undergo a process of restabilization, known as reconsolidation, to be maintained. The findings that stabilized memories can become labile have challenged the classical view of how memories are consolidated over time and stored. On the other hand, the reconsolidation process is not fully understood, and theories about the nature and function of memory reconsolidation remain controversial. In this paper, I will present my view on some of the controversial issues of memory reconsolidation and propose a hypothetical model for how this process contributes to memory stabilization. The debated issues that will be discussed are: (1) The term reconsolidation; (2) Temporal constraints of memory reconsolidation; (3) Classical theory of memory consolidation versus theory of memory reconsolidation; (4) Procedural constraints: what is it that needs to be reactivated to produce memory fragility? (5) Functions of memory reconsolidation; (6) Disrupting reconsolidation: an impairment of memory stabilization or retrieval?

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“…While some have obtained spontaneous memory recovery under these circumstances (e.g., Cooper & Koppenaal, 1964;Kohlenberg & Trabasso, 1968;Nielson, 1968;Young & Galluscio, 1971) Greenough, Schwitzgebel, & Fulcher, 1968;Herz & Peeke, 1967;Luttges & McGaugh, 1967). Even when parameters have been carefully adjusted to maximize the effect (DeVietti et al, 1973; DeVietti & Hopfer, in press b), little more than nonsignificant trends toward memory recovery have been obtained. However, a recent study (DeVietti et al, in press) may shed new light on the problem.…”

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confidence: 99%

“…This state dependency view has received support largely from experiments which have administered footshock and ECS a day or more following training, with retention tested at several intervals posttreatment. This paradigm has consistently demonstrated a transient amnesia resulting from footshock ECS (DeVietti, Holliday, & Larson, 1973;DeVietti & Larson, 1971;DeVietti, Mayse, & Morris, in press). However, the evidence that the state dependency effect acts to influence the amnesia induced in the typical ECS paradigm, i.e., when ECS follows a training trial footshock, is less than compelling.…”

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confidence: 99%

ECS-induced amnesia: Retention function consistent with state dependency predictions

DeVietti

Hopfer

1974

Psychobiology

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Comparison of amnesias induced by electroconvulsive shock administered after training-trial footshock or noncontingent footshock in rats.

Cited by 14 publications

References 26 publications

The Role of Reconsolidation and the Dynamic Process of Long-Term Memory Formation and Storage

The Role of Reconsolidation and the Dynamic Process of Long-Term Memory Formation and Storage

Reconsolidation: the samsara of memory consolidation

ECS-induced amnesia: Retention function consistent with state dependency predictions

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