Comparison of amino acid concentrations in amniotic fluid from fetal neural tube defective and normal pregnancies

Pettit, Brian R.; Allen, John T.

doi:10.1016/0009-8981(80)90132-1

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…Similarly, a decreased serum concentration of valine (FC = 0.50, P < 0.05) and 3-methyl-2-oxovaleric acid (FC = 0.56, P < 0.05) was also observed in the DBP-treated mice (Supplementary Table S3, Supporting Information). The decreased levels of BCAAs were previously reported in the amniotic fluid of pregnant women with spina bifida offspring as compared to controls . The depletion of BCAAs in maternal serum may further impact the neurodevelopmental process with an insufficient nitrogen source for the synthesis of neurotransmitter glutamate.…”

Section: Discussionmentioning

confidence: 74%

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Metabolic Signature of Pregnant Women with Neural Tube Defects in Offspring

Zheng

Pei

et al. 2011

J. Proteome Res.

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Neural tube defects (NTDs) are one of the most common types of birth defects, affecting approximately 1 of every 1000 pregnancies in the United States and an estimated 300 000 newborns worldwide each year. The metabolic signature of pregnant women with NTDs in offspring has not previously been characterized. In this paper, we report a profiling study that characterized the serum metabolome of 101 pregnant women affected with NTDs in offspring in comparison with 143 pregnant women with normal pregnancy outcomes in Lvliang prefecture, the area with the highest birth prevalence of NTDs in China. A serum metabonomic study was also conducted to identify significantly altered metabolites associated with di-n-butyl phthalate (DBP)-induced teratogenesis in mice. The metabolic signature of NTD in pregnant women is characterized by the impaired mitochondrial respiration, neurotransmitter γ-aminobutyric acid, and methionine cycle. Of interest, consistent findings from DBP-induced teratogenesis in mice demonstrated increased succinate and decreased fumarate, suggesting an inhibited succinic dehydrogenase implicated in the defective mitochondria. The characteristic disruption of maternal metabolism offers important insights into metabolic mechanisms underlying human NTDs as well as potential preventive strategies.

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Section: Discussionmentioning

confidence: 74%

“…The decreased levels of BCAAs were previously reported in the amniotic fluid of pregnant women with spina bifida offspring as compared to controls. 54 The depletion of BCAAs in maternal serum may further impact the neurodevelopmental process with an insufficient nitrogen source for the synthesis of neurotransmitter glutamate.…”

Section: ' Discussionmentioning

confidence: 99%

Metabolic Signature of Pregnant Women with Neural Tube Defects in Offspring

Zheng

Pei

et al. 2011

J. Proteome Res.

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Elevated midtrimester serum methylmalonic acid levels as a risk factor for neural tube defects

et al. 1995

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The role of folic acid in the primary prevention of neural tube defects (NTDs) is well established. However, questions related to the protective mechanism remain unanswered. To help answer these questions, we designed a case-control study to assess the role of folate- and cobalamin-related metabolites in the pathogenesis of NTDs. Concentrations of folate, cobalamin, and 14 other related metabolites were measured by gas chromatography/mass spectrometry in midtrimester serum specimens from 32 women with an NTD-affected pregnancy and from 132 control women, and in serum specimens from 46 nonpregnant women who had a history of NTD-affected pregnancy and from 43 nonpregnant control women. Log-transformed means of metabolites were compared between case and control women for both the midtrimester and nonpregnant groups. In the pregnant group, serum methylmalonic acid (MMA) concentrations were higher among case women than among control women (130 vs 105 nM). There was a strong dose-response relationship between midtrimester serum MMA level and the risk for an NTD-affected pregnancy, with the relative risk increasing 13-fold for women with MMA levels > 90th percentile. In the nonpregnant group, there was no difference in serum MMA levels between case and control women (140 vs 140 nM). Thus, the serum MMA levels of women in the midtrimester of pregnancies unaffected by NTDs were significantly lower than the levels of nonpregnant women, whereas the levels of women whose pregnancies were affected by NTDs were similar to those of nonpregnant women. The finding of elevated MMA serum concentrations among women in the midtrimester of NTD-affected pregnancies suggests that cobalamin may be involved in the etiology of NTDs. The possible role of cobalamin in relation to the protective effect of folic acid needs further evaluation.

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Pharmacokinetics of oral and intravenous melphalan during routine treatment of multiple myeloma

Bosanquet

Gilby

1982

European Journal of Cancer and Clinical Oncology

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Comparison of amino acid concentrations in amniotic fluid from fetal neural tube defective and normal pregnancies

Cited by 3 publications

References 8 publications

Metabolic Signature of Pregnant Women with Neural Tube Defects in Offspring

Metabolic Signature of Pregnant Women with Neural Tube Defects in Offspring

Elevated midtrimester serum methylmalonic acid levels as a risk factor for neural tube defects

Pharmacokinetics of oral and intravenous melphalan during routine treatment of multiple myeloma

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