Comparison of Alteration in Liver Function Tests in Patients undergoing High Pressure Laparoscopic Cholecystectomy Versus Low Pressure Cholecystectomy

Goyal, Manav; Bansiwal, Rajesh Kumar; Mehta, D.

doi:10.21276/ijcmr.2020.7.6.3

Cited by 1 publication

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“…Some studies proved that the variations in liver function tests were directly proportional to the duration and pressure used for pneumoperitoneum. 11 This suggested that LC is not the choice of treatment in patients with severe liver diseases or liver cirrhosis because it can det In our study the intra-abdominal pressure was kept between 12-14 mmHg and since CO2 pneumoperitoneum was used so this might be one of the reason contributing to the findings.…”

Section: Discussionmentioning

confidence: 84%

Changes in liver function tests in laparoscopic cholecystectomy versus open cholecystectomy in a tertiary care center

Shashank Kumar,

Ashika Happy,

Shishir Kumar

et al. 2023

Int J Res Med Sci

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Background: Gallstone disease is a major health problem worldwide particularly in the adult population. The traditional open cholecystectomy (OC) has been replaced by laparoscopic cholecystectomy (LC), with LC becoming the gold standard for management of gall stone disease. Elevation in the levels of liver enzymes following LC is a major cause of concern. Hence the present study determines and compares the changes in liver function tests following Laparoscopic cholecystectomy with open cholecystectomy, as well the significance of these changes is studied. Methods: A total of 100 patients with symptomatic cholelithiasis were selected in the study from October 2020 to October 2022. The cases were randomly divided into two groups, Group LC and Group OC. The blood samples were collected for Liver Function Tests (LFT)-Pre-operatively, Post-operative Day (POD)-1, POD-2 and POD-7 and enzyme alterations were studied. Results: The study demonstrated increase in levels of Serum AST, ALT, ALP in LC group on POD-1 and POD-2 with p<0.001, while the levels returned to reference values on POD-7. In OC group the increase in levels of Serum AST, ALT, ALP were observed on POD-1 only with p<0.05 and the levels returned to normal values by POD-2 of majority of patients. The changes in LFT were higher in LC group compared to OC group (where the changes were slight). Conclusions: Cholecystectomy especially laparoscopic, leads to transient significant hepatic enzyme alterations which can be attributed to CO2 pneumoperitoneum, surgical manipulations, diathermy and arterial injury. These derangements at times may be of concern to surgeons for its implication to the integrity of biliary tract.

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Section: Discussionmentioning

confidence: 84%