Many specifics of neural systems are not well addressed by the conventional models currently used in different applications. The purpose of the special issue is to present and discuss novel ideas, work and results related to alternative techniques of neural system approaches based on bio-inspired intelligence, which depart from mainstream procedures. Recent studies based on complex system opened new doors in research field and in particular improved the quality and the results of diverse applications. Neural system approaches on bio-inspired intelligence contributed a lot to this fact, also in areas like speech, biomedicine, biometrics, signals and images, and other applications. This special issue aims to bring together researchers to report the latest research findings and developments of bioinspired intelligence and to explore future research directions. This special issue includes works in three areas, which are set in the following topics;