Comparison of albumin, colloid osmotic pressure, von Willebrand factor, and coagulation factors in canine cryopoor plasma, cryoprecipitate, and fresh frozen plasma

Abstract

The mean albumin concentration and COP were highest in CPP, suggesting that CPP may be a potential alternative to FFP for oncotic support and albumin replacement. CRYO contained higher activities of vWf and factor VIII than other products and could be used to treat vWf deficiency and hemophilia A. As vitamin K dependent coagulation factors II, VII, and X in CPP were similar to FFP, CPP may be an option for replacement of most of vitamin K dependent factors.

Clinical use of cryopoor plasma continuous rate infusion in critically ill, hypoalbuminemic dogs

“…There are limited published data on the use of CPP in people, but it may be used in lieu of FFP for treatment of disseminated intravascular coagulation and for plasma exchange in cases of thrombotic thrombocytopenic purpura . In veterinary medicine, some suggest CPP for use in hypoalbuminemic patients and for treatment of vitamin K antagonist rodenticide toxicity, although until a previous study by our group, no published data on the content of CPP existed . Our study showed that CPP contains higher concentrations of albumin and has a higher COP than FFP, supporting its use as a potential treatment option for hypoalbuminemia.…”

“…This is not surprising, given that HES has a higher oncotic pressure than plasma . A previous study reported HES 6% 670/0.75/4:1 to have a COP of 32.7 mm Hg, while our previous study found the COP of CPP to be 14.5 mm Hg . Given this large difference in COP between the 2 products, whatever COP benefit may have been gained by the increase in albumin was likely overshadowed by the COP influence of HES.…”

“…Our study showed that CPP contains higher concentrations of albumin and has a higher COP than FFP, supporting its use as a potential treatment option for hypoalbuminemia. Specifically, the mean albumin and COP in CPP were significantly higher than in FFP, with 31.7 g/L (±0.7) in CPP compared to 28.9 g/L (±0.5) in FFP ( P < 0.001) and 14.5 mm Hg (±0.65) in CPP compared 12.73 mm Hg (± 0.31) in FFP ( P = 0.03), respectively . At our blood bank, the cost of CPP is approximately half the cost of FFP by volume, potentially making CPP a more financially feasible option.…”

“…Veterinary references recommend a dose of 2 g/kg/d of HSA that would equate to approximately 70 mL/kg/d of FFP . In contrast, human studies report administering albumin at a dose of approximately 0.8–0.9 g/kg/day, which, based on our previous study, is the equivalent of 28–31 mL/kg/day of FFP and 25–28 mL/kg/day of CPP …”

“…Fresh frozen plasma (FFP) may be given to provide albumin and oncotic support, but given the large volume is needed to treat hypoalbuminemia, it may be too expensive to be a feasible option for many dog owners . A previous study conducted by the authors showed that the albumin content of cryopoor plasma (CPP) is clinically similar to FFP, suggesting that it may be a possible treatment option for hypoalbuminemia . At the authors’ institution, CPP is approximately half the cost of FFP by volume and thus may offer a more cost‐effective treatment option for hypoalbuminemia.…”