Comparison of Agonist and Antagonist of GnRH in Induction Ovulation in Infertile Couples with Male Factor Referred to Fatemieh Hospital of Hamadan

Abstract

Background and Objective: Infertility and its treatment are among the most important challenges in the field of gynecology. This study aimed to compare two methods of administration of GnRH agonists and GnRH antagonists on the occurrence of pregnancy. Materials and Methods: This randomized controlled clinical trial included 84 infertile couples with male factor infertility problems referred to Fatemieh Hospital, Hamadan, Iran. They were randomly assigned into two groups of 42 cases. The first group was treated with GnRH agonist (Bucereline), and GnRH antagonists (Cetrotide) was administered to the second group. The two groups were compared with each other regarding the incidence of pregnancy, number of oocytes obtained, the mean days of induction, the number of fertilized oocytes, the incidence of Ovarian Hyperstimulation Syndrome (OHSS), and treatment costs. Results: The findings showed that the rates of clinical pregnancy were 19 (45.23%) and 7 cases (16.67%) in the agonist and antagonist groups, respectively. Moreover, there was a significant difference between the groups in this regard (P<0.009). Furthermore, the number of fertilized oocytes in the agonist group was significantly higher than that in the antagonist group (P<0.004). In addition, the mean induction days in the antagonist group was significantly lower, compared to another group (P<0.001). There was no significant difference between the two groups regarding the incidence of OHSS syndrome and the overall cost of treatment. Conclusion: According to the results, the efficacy of agonist drugs was much better than that of the antagonist medications in terms of the occurrence of pregnancy. However, no significant difference was observed between the groups regarding the complications.