Comparison of Aerosol Stability of Different Variants of Ebola Virus and Marburg Virus and Virulence of Aerosolised Ebola Virus in an Immune-Deficient Mouse

Smither, Sophie J.; Eastaugh, Lin; Lever, Mark S.

doi:10.3390/v14040780

Cited by 3 publications

(2 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, in-depth research on respiratory infectious diseases such as Severe Acute Respiratory Syndrome (SARS) in 2002, H1N1 influenza in 2009, and Middle East Respiratory Syndrome (MERS) in 2012 shed light on the transmission mechanisms of these diseases. These flu viruses can spread through tiny droplets expelled from an infected individual's respiratory tract during sneezing or coughing, forming dispersed viral bioaerosols that can be inhaled by others, thereby facilitating the spread of the virus [18]. As most transmission routes of these diseases are associated with airborne particles and the lungs serve as the primary site for gas exchange in the body, the lungs become susceptible to infection.…”

Section: Analysis Of Research Trendsmentioning

confidence: 99%

Navigating the Aerosolized Frontier: A Comprehensive Review of Bioaerosol Research Post-COVID-19

Zhang,

Dai,

Gebrezgiabhier

et al. 2024

Atmosphere

View full text Add to dashboard Cite

In the wake of the COVID-19 pandemic, the scientific community has been galvanized to unravel the enigmatic role of bioaerosols in the transmission of infectious agents. This literature review, anchored in the extensive Web of Science Core Collection database covering the period from 1990 to 2023, utilizes a bibliometric approach to chart the dynamic landscape of bioaerosol research. It meticulously documents the paradigm shifts and burgeoning areas of inquiry that have emerged in the aftermath of the pandemic. This review meticulously maps out the sources and detection strategies of pathogens in a variety of ecosystems. It clearly shows that impaction and filtration sampling methods, followed by colony counting and PCR-based detection techniques, were predominantly used in the scientific works within the previous three decades. It synthesizes the progress and limitations inherent in a range of models for predicting aerosol-mediated pathogen spread and provides a comparative analysis of eDNA technology and traditional analytical techniques for bioaerosols. The accuracy of these detection methods and forecasting models is paramount for the early recognition of transmission risks, which, in turn, paves the way for prompt and effective disease mitigation strategies. By providing a thorough analysis of the historical progression and current state of bioaerosol research, this review illuminates the path ahead, identifying the critical research needs that will drive the field’s advancement in the years to come.

show abstract

Section: Analysis Of Research Trendsmentioning

confidence: 99%

Navigating the Aerosolized Frontier: A Comprehensive Review of Bioaerosol Research Post-COVID-19

Zhang,

Dai,

Gebrezgiabhier

et al. 2024

Atmosphere

View full text Add to dashboard Cite

show abstract

“…For this reason, it highlights the need to develop new biomarkers to help diagnose CCHFV. Platelets, AST, ALT, first-step coagulation assays, LDH creatinine, and fibrinogen have all been identified as laboratory indications of CCHFV [68][69][70]. After the acute phase of the infection, which lasts 4-9 days after symptoms appear, active CCHFV infection may be identified by IgM or a substantial rise in IgG titer; however, severe and fatal cases often do not develop a detectable Ab response.…”

Section: Standard Molecular Detectionmentioning

confidence: 99%

Recent Advances in Crimean-Congo Hemorrhagic Fever Virus Detection, Treatment, and Vaccination: Overview of Current Status and Challenges

Muzammil,

Rayyani,

Abbas Sahib

et al. 2024

Biol Proced Online

View full text Add to dashboard Cite

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus, and zoonosis, and affects large regions of Asia, Southwestern and Southeastern Europe, and Africa. CCHFV can produce symptoms, including no specific clinical symptoms, mild to severe clinical symptoms, or deadly infections. Virus isolation attempts, antigen-capture enzyme-linked immunosorbent assay (ELISA), and reverse transcription polymerase chain reaction (RT-PCR) are all possible diagnostic tests for CCHFV. Furthermore, an efficient, quick, and cheap technology, including biosensors, must be designed and developed to detect CCHFV. The goal of this article is to offer an overview of modern laboratory tests available as well as other innovative detection methods such as biosensors for CCHFV, as well as the benefits and limits of the assays. Furthermore, confirmed cases of CCHF are managed with symptomatic assistance and general supportive care. This study examined the various treatment modalities, as well as their respective limitations and developments, including immunotherapy and antivirals. Recent biotechnology advancements and the availability of suitable animal models have accelerated the development of CCHF vaccines by a substantial margin. We examined a range of potential vaccines for CCHF in this research, comprising nucleic acid, viral particles, inactivated, and multi-epitope vaccines, as well as the present obstacles and developments in this field. Thus, the purpose of this review is to present a comprehensive summary of the endeavors dedicated to advancing various diagnostic, therapeutic, and preventive strategies for CCHF infection in anticipation of forthcoming hazards. Graphical Abstract

show abstract

Aerosol Survival, Disinfection and Formalin Inactivation of Nipah Virus

Smither

Eastaugh

O’Brien

et al. 2022

Viruses

View full text Add to dashboard Cite

Nipah virus is a relatively newly discovered emerging virus on the WHO list of priority pathogens which has the potential to cause outbreaks with high fatality rates. Whilst progress is being made in the development of animal models for evaluating vaccines and therapies, some of the more fundamental data on Nipah virus are lacking. We performed studies to generate novel information on the aerosol survival of Nipah virus and to look at the efficacy of two common disinfectants. We also performed studies to evaluate the inactivation of Nipah virus by using neutral buffered formalin. Nipah virus was relatively stable in a small particle (1–5 µm) aerosol in the dark, with it having a decay rate of 1.46%min−1. Sodium hypochlorite (at 10%) and ethanol (at 80%) reduced the titre of Nipah virus to undetectable levels. Nipah virus that was in tissue culture medium was also inactivated after 24 h in the presence of 10% formalin.

show abstract

Comparison of Aerosol Stability of Different Variants of Ebola Virus and Marburg Virus and Virulence of Aerosolised Ebola Virus in an Immune-Deficient Mouse

Cited by 3 publications

References 36 publications

Navigating the Aerosolized Frontier: A Comprehensive Review of Bioaerosol Research Post-COVID-19

Navigating the Aerosolized Frontier: A Comprehensive Review of Bioaerosol Research Post-COVID-19

Recent Advances in Crimean-Congo Hemorrhagic Fever Virus Detection, Treatment, and Vaccination: Overview of Current Status and Challenges

Aerosol Survival, Disinfection and Formalin Inactivation of Nipah Virus

Contact Info

Product

Resources

About