Comparison of Adaptive Neuroprotective Mechanisms of Sulforaphane and its Interconversion Product Erucin in <i>in Vitro</i> and <i>in Vivo</i> Models of Parkinson’s Disease

Morroni, Fabiana; Sita, Giulia; Djemil, Alice; D’Amico, Massimo; Pruccoli, Letizia; Cantelli‐Forti, Giorgio; Hrelia, Patrizia; Tarozzi, Andrea

doi:10.1021/acs.jafc.7b04641

Cited by 46 publications

(32 citation statements)

References 41 publications

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“…Sulforaphane, an isothiocyanate hydrolyzed from glucoraphanin, has received the most attention. In addition, the enzymolytic ITCs from gluconapin and glucoerucin are 1-butene-4-isothiocyanat and erucin, which also presented anticancer effects in vitro and in vivo (Melchini and Traka, 2010;Morroni et al, 2018). In the present study, sulforaphane concentration accounted for 62.59% of total ITCs in broccoli sprouts.…”

Section: Discussionsupporting

confidence: 46%

Effect of jasmonic acid on glucosinolate metabolism in different organs of broccoli sprouts

Zhu

Wang²,

Guo³

2019

Emir J Food Agric

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Edible sprouts, especially Brassica sprouts, contain high levels of health-promoting compounds. Exogenous elicitors have been used as strategies to improve the nutraceutical quality of Brassica sprouts. In this study, effects of jasmonic acid (JA) treatment on growth, the levels of glucosinolates and isothiocyanates, as well as myrosinase activity in different organs of broccoli sprouts were investigated. JA treatment markedly increased the contents of glucosinolates (GSLs), especially glucoraphanin, glucobrassicin and neoglucobrassicin in broccoli sprouts. However, gluconapin was not affected even decreased by JA treatment. Cotyledon, hypocotyl and root obtained the different results in induction of GSLs. Among these, neoglucobrassicin obtained the highest enhancement in three organs. Myrosinase activity in cotyledon of broccoli increased after JA treatment, while decreased in hypocotyl. Three concentrations of JA all significantly increased sulforaphane and isothiocyanates formation in cotyledon, hypocotyl and root of broccoli sprouts. Application of 100 μM JA led to the highest myrosinase activity, the least gluconapin and the most sulforaphane and isothiocyanates in cotyledon, as well as the most isothiocyanates in root. These results indicated that JA treatment could be an effective way to improve the cancer-prevention benefits of broccoli sprouts via enhancing sulforaphane and total isothiocyanates.

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Section: Discussionsupporting

confidence: 46%

Effect of jasmonic acid on glucosinolate metabolism in different organs of broccoli sprouts

Zhu

Wang²,

Guo³

2019

Emir J Food Agric

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“…The GSH levels were evaluated in SH-SY5Y cells as previously described [ 28 ]. SH-SY5Y cells were seeded in a black 96-well plate at 2 × 10 4 cells/well and incubated for 24 h at 37 °C in 5% CO 2 .…”

Section: Methodsmentioning

confidence: 99%

Exploiting the Chalcone Scaffold to Develop Multifunctional Agents for Alzheimer’s Disease

et al. 2018

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Alzheimer’s disease still represents an untreated multifaceted pathology, and drugs able to stop or reverse its progression are urgently needed. In this paper, a series of naturally inspired chalcone-based derivatives was designed as structural simplification of our previously reported benzofuran lead compound, aiming at targeting both acetyl (AChE)- and butyryl (BuChE) cholinesterases that, despite having been studied for years, still deserve considerable attention. In addition, the new compounds could also modulate different pathways involved in disease progression, due to the peculiar trans-α,β-unsaturated ketone in the chalcone framework. All molecules presented in this study were evaluated for cholinesterase inhibition on the human enzymes and for antioxidant and neuroprotective activities on a SH-SY5Y cell line. The results proved that almost all the new compounds were low micromolar inhibitors, showing different selectivity depending on the appended substituent; some of them were also effective antioxidant and neuroprotective agents. In particular, compound 4, endowed with dual AChE/BuChE inhibitory activity, was able to decrease ROS formation and increase GSH levels, resulting in enhanced antioxidant endogenous defense. Moreover, this compound also proved to counteract the neurotoxicity elicited by Aβ1–42 oligomers, showing a promising neuroprotective potential.

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“…Recently, it was reported that carnosic acid (CA) exerts antioxidant effects through activation of Nrf2, the latter upregulating expression of some of endogenous antioxidants such as GPx, glutathione reductase (GR) [ 106 ]. Moreover, isothiocyanate sulforaphane (SFN), another Nrf2 activator, also displays neuroprotective effects in PD models [ 107 ]. All those studies suggest that Nrf2 is a pivotal mediator of cellular antioxidative stress system.…”

Section: Anti-ros With Compounds For the Therapeutics Of Pdmentioning

confidence: 99%

The Sources of Reactive Oxygen Species and Its Possible Role in the Pathogenesis of Parkinson’s Disease

Weng

Xie

Liu

et al. 2018

Parkinson's Disease

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Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra. The precise mechanism underlying pathogenesis of PD is not fully understood, but it has been widely accepted that excessive reactive oxygen species (ROS) are the key mediator of PD pathogenesis. The causative factors of PD such as gene mutation, neuroinflammation, and iron accumulation all could induce ROS generation, and the later would mediate the dopaminergic neuron death by causing oxidation protein, lipids, and other macromolecules in the cells. Obviously, it is of mechanistic and therapeutic significance to understand where ROS are derived and how ROS induce dopaminergic neuron damage. In the present review, we try to summarize and discuss the main source of ROS in PD and the key pathways through which ROS mediate DA neuron death.

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Comparison of Adaptive Neuroprotective Mechanisms of Sulforaphane and its Interconversion Product Erucin in in Vitro and in Vivo Models of Parkinson’s Disease

Cited by 46 publications

References 41 publications

Effect of jasmonic acid on glucosinolate metabolism in different organs of broccoli sprouts

Effect of jasmonic acid on glucosinolate metabolism in different organs of broccoli sprouts

Exploiting the Chalcone Scaffold to Develop Multifunctional Agents for Alzheimer’s Disease

The Sources of Reactive Oxygen Species and Its Possible Role in the Pathogenesis of Parkinson’s Disease

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