Comparison of Acute Toxicity of Anticholinesterase Insecticides to Weanling and Adult Male Rats

Brodeur, Jean‐Paul; DuBois, Kenneth P.

doi:10.1097/00043764-196403000-00027

Cited by 18 publications

(26 citation statements)

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“…The greatest difference in LD50 values, 27.5-fold, was measured in newborn rats (Lu et al 1965). As the pups matured, the LD50 ratios decreased, being measured at 7.2-fold in PND12, 4-4.5-fold in PND14-18, and 2.2-fold in weanling rats (Brodeur and DuBois 1963;Lu et al 1965). Our difference of 3-fold or greater for ChE inhibition agrees well with these values, despite the different endpoints.…”

Section: Organophosphatessupporting

confidence: 84%

“…It is important to note that while we have not studied parathion or methyl parathion, ratios of sensitivity differences from the literature range from around 8-fold in newborn to PND7 rats, to less than 2-fold in weanling pups (Benke and Murphy, 1975;Brodeur and DuBois, 1963;Harbison, 1975;Pope and Chakraborti, 1992). This information could add two more OP pesticides to the group that show sensitivity ratios >3-fold at approximately PND17; however, they are not added to Table 1 or 3 since we did not test those pesticides in this laboratory.…”

Section: Age-related Differences In Acetylcholinesterase Inhibition Pmentioning

confidence: 86%

“…Besides our studies on ChE inhibition, the literature has only provided lethality data. Methomyl and carbaryl were not more sensitive to lethality in post-weaning (3-6 weeks of age) rats (Brodeur and DuBois, 1963;Gaines and Lindner, 1986). We observed essentially no differences in PND17 rats with either pesticide, but younger rats (PND11) were 1.6-fold more sensitive with carbaryl.…”

Section: Carbamatesmentioning

confidence: 96%

“…LD50s in PND23 rats (Brodeur and DuBois, 1963). No other dose-response data with which to compare point estimates could be found for the remaining OPs.…”

Section: Age-related Differences In Acetylcholinesterase Inhibition Pmentioning

confidence: 99%

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Age-Related Differences in Acetylcholinesterase Inhibition Produced by Organophosphorus and N-Methyl Carbamate Pesticides

Moser¹

2011

Pesticides in the Modern World - Pests Control and Pesticides Exposure and Toxicity Assessment

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Section: Organophosphatessupporting

confidence: 84%

Section: Age-related Differences In Acetylcholinesterase Inhibition Pmentioning

confidence: 86%

Section: Carbamatesmentioning

confidence: 96%

“…LD50s in PND23 rats (Brodeur and DuBois, 1963). No other dose-response data with which to compare point estimates could be found for the remaining OPs.…”

Section: Age-related Differences In Acetylcholinesterase Inhibition Pmentioning

confidence: 99%

See 2 more Smart Citations

Age-Related Differences in Acetylcholinesterase Inhibition Produced by Organophosphorus and N-Methyl Carbamate Pesticides

Moser¹

2011

Pesticides in the Modern World - Pests Control and Pesticides Exposure and Toxicity Assessment

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“…Tests on young rodents demonstrate a progressive decrease in susceptibility to OP pesticides with increasing age (13, [123][124][125]. In some cases, the lethal dose in immature animals is only 1% of the adult lethal dose (92,93,97).…”

Section: Potential Respiratory Health Effectsmentioning

confidence: 99%

Exposures of children to organophosphate pesticides and their potential adverse health effects.

Eskenazi

Bradman

Castorina

1999

Environ Health Perspect

582

338

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Recent studies show that young children can be exposed to pesticides during normal oral exploration of their environment and their level of dermal contact with floors and other surfaces. Children living in agricultural areas may be exposed to higher pesticide levels than other children because of pesticides tracked into their homes by household members, by pesticide drift, by breast milk from their farmworker mother, or by playing in nearby fields. Nevertheless, few studies have assessed the extent of children's pesticide exposure, and no studies have examined whether there are adverse health effects of chronic exposure. There is substantial toxicologic evidence that repeated low-level exposure to organophosphate (OP) pesticides may affect neurodevelopment and growth in developing animals. For example, animal studies have reported neurobehavorial effects such as impairment on maze performance, locomotion, and balance in neonates exposed (italic)in utero(/italic) and during early postnatal life. Possible mechanisms for these effects include inhibition of brain acetylcholinesterase, downregulation of muscarinic receptors, decreased brain DNA synthesis, and reduced brain weight in offspring. Research findings also suggest that it is biologically plausible that OP exposure may be related to respiratory disease in children through dysregulation of the autonomic nervous system. The University of California Berkeley Center for Children's Environmental Health Research is working to build a community-university partnership to study the environmental health of rural children. This Center for the Health Assessment of Mothers and Children of Salinas, or CHAMACOS in Monterey County, California, will assess (italic)in utero(/italic) and postnatal OP pesticide exposure and the relationship of exposure to neurodevelopment, growth, and symptoms of respiratory illness in children. The ultimate goal of the center is to translate research findings into a reduction of children's exposure to pesticides and other environmental agents, and thereby reduce the incidence of environmentally related disease.

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Maturational differences in chlorpyrifos-oxonase activity may contribute to age-related sensitivity to chlorpyrifos

Mortensen

Chanda

Hooper

et al. 1996

J. Biochem. Toxicol.

118

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Comparison of Acute Toxicity of Anticholinesterase Insecticides to Weanling and Adult Male Rats

Cited by 18 publications

References 0 publications

Age-Related Differences in Acetylcholinesterase Inhibition Produced by Organophosphorus and N-Methyl Carbamate Pesticides

Age-Related Differences in Acetylcholinesterase Inhibition Produced by Organophosphorus and N-Methyl Carbamate Pesticides

Exposures of children to organophosphate pesticides and their potential adverse health effects.

Maturational differences in chlorpyrifos-oxonase activity may contribute to age-related sensitivity to chlorpyrifos

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