Comparison of acute effects of red wine, beer and vodka against hyperoxia-induced oxidative stress and increase in arterial stiffness in healthy humans

Krnić, Mladen; Modun, Darko; Budimir, Danijela; Gunjaca, Grgo; Jajić, Ivan; Vuković, Jonatan; Salamunić, Ilza; Sutlović, Davorka; Kozina, Bernard; Boban, Mladen

doi:10.1016/j.atherosclerosis.2011.07.004

Cited by 33 publications

(41 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, both ethanol and antioxidants seem to reduce pressure wave reflections, but the contribution of ethanol seems to play the leading part in reducing AIx. This is in accordance with previous studies in red wine, which however have shown that both ethanol and antioxidants may reduce AIx postprandially [12, 15-17]. However, beer antioxidants differ from those found in red wine [5], which is a possible explanation for the divergent findings.…”

Section: Discussionsupporting

confidence: 92%

“…The possible postprandial effects of ethanol and antioxidants found in alcoholic drinks have not been well investigated. In one study including 8 healthy volunteers, red wine (0.8gr/kg body weight) reduced PWV, while dealcoholized red wine had no such effect, suggesting that only ethanol but not red wine antioxidants had a significant beneficial effect on arterial stiffness [12]. To our knowledge there is no previous study investigating the acute effects of antioxidants found in alcoholic drinks, in arterial stiffness.…”

Section: Discussionmentioning

confidence: 99%

“…As with other alcohol beverages, a moderate daily beer consumption appears to be negatively associated with blood pressure and cardiovascular disease but higher daily dose may have detrimental effects, leading to a J- shape or U-shape relation [6]. A few studies have investigated the effect of beer on arterial function in comparison to red wine [12-13]. To our knowledge there are no data regarding the effect of acute beer intake on arterial biomarkers of atherosclerosis (pulse wave velocity (PWV), augmentation index (Aix), flow mediated dilation (FMD) as well as on aortic pressure.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Acute effects of beer on endothelial function and hemodynamics: A single-blind, crossover study in healthy volunteers

Karatzi

Rontoyanni²,

Protogerou³

et al. 2013

Nutrition

View full text Add to dashboard Cite

Objective-Moderate consumption of beer is associated with lower cardiovascular (CV) risk. To explore the underlying mechanisms we studied the acute effects of the constituents of beer (alcohol and antioxidants), on established predictors of CV risk: endothelial function, aortic stiffness, pressure wave reflections and aortic pressure.Research Methods & Proceedures-In a randomized, single -blind, cross -over study 17 healthy, non-smoking, volunteers (28.5±5.2 years and 24.4±2.5 BMI) consumed in 3 separate days, at least one week apart: a) 400 ml of beer & 400 ml water, b) 800 ml of dealcoholized beer (same amount of polyphenols), and c) 67 ml of vodka & 733 ml water (same amount of alcohol). Each time aortic stiffness (pulse wave velocity, pressure wave reflections (Aix), aortic and brachial pressure (Sphygmocor device) and endothelial function (brachial flow mediated dilatation) were assessed at fast and 1 and 2 hours postprandial.Results-Aortic stiffness was significantly and similarly reduced by all 3 interventions. However, endothelial function was significantly improved only after beer consumption (average of 1.33%, CI 0.15-2.53). Although wave reflections were significantly reduced by all 3 interventions (average of beer: 9.1%, dealcoholized beer: 2.8%, vodka 8.5%, all CI within limits of significance), the reduction was higher after beer consumption compared todealcoholized beer (p=0.018). Pulse pressure amplification (i.e. brachial/aortic) was increased by all 3 test drinks.Corresponding author: Kalliopi Karatzi PhD, Department of Nutrition and Dietetics, Harokopio University, Athens, Greece. 8 Mykonou str., Voula, 16673, Athens, Greece. Tel/Fax: + 30 210 8950786, pkaratzi@hua.gr. The authors declare that they have no conflict of interest. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptConclusions-Beer improves acutely parameters of arterial function and structure, in healthy non-smokers. This benefit seems to be mediated by the additive or synergistic effects of alcohol and anti-oxidants and merits further investigation.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Acute effects of beer on endothelial function and hemodynamics: A single-blind, crossover study in healthy volunteers

Karatzi

Rontoyanni²,

Protogerou³

et al. 2013

Nutrition

View full text Add to dashboard Cite

show abstract

“…Rather, we believe that 'oxidative stress' constitutes a ubiquitous fundamental biological response to the alteration of redox homeostasis imposed by the physical stress of exercise. In support to this, oxidative stress has been reported after every possible stress employed, such as increased temperature (Lushchak and Bagnyukova, 2006); decreased temperature (Qiu et al, 2011), acidic pH and alkaline pH (Wang et al, 2009); as well as hypoxia (Sharma et al, 2011) and hyperoxia (Krnic et al, 2011). There is no doubt that although diverse stimuli induce redox homeostasis alterations and/or oxidative stress, the effects of these alterations on biological adaptations are translated differently in many (or all) cases.…”

Section: Conclusion and The Way Aheadmentioning

confidence: 93%

Redox biology of exercise: an integrative and comparative consideration of some overlooked issues

Nikolaidis

Kyparos

Spanou

et al. 2012

Journal of Experimental Biology

124

152

View full text Add to dashboard Cite

SummaryThe central aim of this review is to address the highly multidisciplinary topic of redox biology as related to exercise using an integrative and comparative approach rather than focusing on blood, skeletal muscle or humans. An attempt is also made to redefine ʻoxidative stressʼ as well as to introduce the term ʻalterations in redox homeostasisʼ to describe changes in redox homeostasis indicating oxidative stress, reductive stress or both. The literature analysis shows that the effects of non-muscledamaging exercise and muscle-damaging exercise on redox homeostasis are completely different. Non-muscle-damaging exercise induces alterations in redox homeostasis that last a few hours post exercise, whereas muscle-damaging exercise causes alterations in redox homeostasis that may persist for and/or appear several days post exercise. Both exhaustive maximal exercise lasting only 30s and isometric exercise lasting 1-3min (the latter activating in addition a small muscle mass) induce systemic oxidative stress. With the necessary modifications, exercise is capable of inducing redox homeostasis alterations in all fluids, cells, tissues and organs studied so far, irrespective of strains and species. More importantly, ʻexercise-induced oxidative stressʼ is not an ʻoddityʼ associated with a particular type of exercise, tissue or species. Rather, oxidative stress constitutes a ubiquitous fundamental biological response to the alteration of redox homeostasis imposed by exercise. The hormesis concept could provide an interpretative framework to reconcile differences that emerge among studies in the field of exercise redox biology. Integrative and comparative approaches can help determine the interactions of key redox responses at multiple levels of biological organization.Key words: antioxidant, biomarker, eccentric, free radical, training. THE JOURNAL OF EXPERIMENTAL BIOLOGY 1616The ʻgoodʼ (antioxidants), the ʻbadʼ (reactive species) and the ʻuglyʼ (oxidative stress) 1 The distinction drawn in the section heading is schematically used to parody the popular manichaeistic view that antioxidants are considered 'useful' entities, reactive species are considered 'harmful' entities and oxidative stress is considered a 'negative' state. Certainly, the reality is much more complicated and antioxidants, reactive species and oxidative stress can serve both useful and detrimental roles, which are dependent on the biological context (within an organism), which in turn are greatly dependent on the environmental context (outside an organism). AntioxidantsAdmittedly, to define the term 'antioxidant' is a difficult task. In this paper, antioxidant is defined as any mechanism, structure and/or substance that delays, prevents or removes oxidative modifications to a target molecule (Halliwell and Gutteridge, 2007;Pamplona and Costantini, 2011). Antioxidants can be complex molecules such as the superoxide dismutases and peroxiredoxins, or simpler ones such as uric acid and glutathione (Gutteridge and Halliwell, 2010). They can be broa...

show abstract

“…When the effects of 3 alcoholic beverages, red wine, beer, and vodka, were compared in a recent study, 15 only red wine provided protection against vascular oxidative stress. Indeed, red wine polyphenols seem to shield the vasculature by reducing reactive oxygen species (eg, by decreasing the expression of p22phox) and by inhibiting endothelin-1 expression.…”

Section: Red Wine Polyphenols Reduce Oxidative Stress and Increase Bimentioning

confidence: 99%

Red Wine and Cardiovascular Health

Förstermann

2012

Circulation Research

View full text Add to dashboard Cite

Downloaded from Circulation ResearchSeptember 28, 2012 resveratrol (≈70%), but several other polyphenols and phenolic acids contribute. 23 Also, both red wine and resveratrol enhance eNOS enzymatic activity. Whereas the effect of resveratrol on eNOS phosphorylation (and activation) mainly involves estrogen receptor-mediated activation of extracellular signalregulated kinases 1 and 2, 24 the phosphorylation (and activation) of eNOS by phenolic extracts from red wine also involves the phosphatidylinositol 3-kinases/Akt pathway. 25 Resveratrol has a low bioavailability.19 Therefore, many in vivo effects of red wine are likely to be attributable to resveratrol metabolites in concert with several other polyphenolic compounds (and possibly their metabolites). Red Wine and Unresolved QuestionsThe beneficial effects of red wine can be enhanced by a healthy diet. Indeed, a synergistic effect of red wine and green olive oil (both are components of the Mediterranean diet) on flow-mediated vasodilation has been demonstrated. 26 The average moderate wine drinker is more likely to exercise, to be health conscious, and to be of a higher educational and socioeconomic status. Nevertheless, there is growing evidence, corroborated by the current study of Chiva-Blanch et al, 11 that chemical constituents present in red wine confer health benefits beyond alcohol and are independent of potential confounding factors. However, numerous issues need to be resolved to clearly assess the preventive or therapeutic potential of red wine constituents. Specific chemical entities responsible for the beneficial effects have to be identified. In this context, one has to realize that there are probably major differences between different red wines, depending on the grape and the growing area. 21 Pharmacological mechanisms leading to increases in vascular NO and other beneficial effects have to be elucidated, and it has to be clarified whether the decrease in blood pressure is causally related to the increased NO levels or what other mechanisms may be involved.Finally, the question whether white wine offers a similar benefit as red remains unresolved. White wine, which is usually fermented without skin and seeds, is missing many of the polyphenols (eg, resveratrol, catechin, quercetin) mainly found in these parts of the grape. There are a few studies 27 demonstrating superior effects of red versus white wine on certain cardiovascular parameters. However, epidemiological evidence demonstrating a specific benefit of red over white wine is poor, 27 and conclusive studies comparing the 2 are missing. In the long run, a prospective, randomized study would be needed to prove or drop the red-better-than-white hypothesis. Sources of FundingOriginal work from our own laboratory contributing to this edi

show abstract

Comparison of acute effects of red wine, beer and vodka against hyperoxia-induced oxidative stress and increase in arterial stiffness in healthy humans

Cited by 33 publications

References 44 publications

Acute effects of beer on endothelial function and hemodynamics: A single-blind, crossover study in healthy volunteers

Acute effects of beer on endothelial function and hemodynamics: A single-blind, crossover study in healthy volunteers

Redox biology of exercise: an integrative and comparative consideration of some overlooked issues

Red Wine and Cardiovascular Health

Contact Info

Product

Resources

About