1995
DOI: 10.1038/bjc.1995.137
|View full text |Cite
|
Sign up to set email alerts
|

Comparison of ability of protein kinase C inhibitors to arrest cell growth and to alter cellular protein kinase C localisation

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

4
57
0
2

Year Published

1995
1995
1999
1999

Publication Types

Select...
7
1

Relationship

1
7

Authors

Journals

citations
Cited by 72 publications
(63 citation statements)
references
References 28 publications
4
57
0
2
Order By: Relevance
“…Staurosporine at 10 -9 M and its analogues UCN-01, RO 31 8220 and GF 109203X in the 10 -7 to 10 .6 M range cause the translocation of PKC-e from the cytosol to the membrane and nucleus of A549 cells [12]. In contrast, CGP 41251 does not possess this property.…”
Section: Discussionmentioning
confidence: 84%
See 1 more Smart Citation
“…Staurosporine at 10 -9 M and its analogues UCN-01, RO 31 8220 and GF 109203X in the 10 -7 to 10 .6 M range cause the translocation of PKC-e from the cytosol to the membrane and nucleus of A549 cells [12]. In contrast, CGP 41251 does not possess this property.…”
Section: Discussionmentioning
confidence: 84%
“…To that end nine well-characterised PKC inhibitors, including staurosporine and four analogues, were investigated with respect to their ability to inhibit PKC prepared from the cytosol or membrane of human-derived MCF-7 breast cancer cells. The susceptibility of these cells towards the growth-arresting ability of PKC inhibitors has recently been described [12]. …”
mentioning
confidence: 99%
“…per well for the 2 and 4 day experiments, respectively, to ensure that similar cell numbers were found in control cultures at both time points. Drug concentrations were between 2 and 5 times the concentration which caused 50% growth inhibition (IC50) after 4 days (Courage et al, 1995).…”
Section: Methodsmentioning
confidence: 99%
“…The following properties were compared: (1) their effects on the cell cycle at equicytostatic concentrations; (2) the time dependency and reversibility associated with their cytostatic properties; and (3) their acute cytotoxic potential. The investigations were performed using human-derived A549 lung carcinoma cells, the growth of which has been shown to be sensitive towards PKC inhibitors (Courage et al, 1995).…”
mentioning
confidence: 99%
“…Studies identifying the cellular pathways affected by UCN-01 resulting in Gl arrest suggest that although UCN-01 possesses potent PKC-inhibitory activity, inhibition of PKC activity is not essential for its growth inhibitory activity (Courage et al, 1995). Recent studies on the role of cell cycle regulators in UCN-01-mediated Gl arrest indicate that in human epidermoid carcinoma A431 cells, UCN-01-induced Gl arrest was accompanied by decreased cyclin-dependent kinase 2 (CDK2) activity and induction of CDK inhibitors p21 and p27 (Akiyama et al, 1997).…”
Section: Introductionmentioning
confidence: 99%