Comparison of Abbreviated Modification of Diet in Renal Disease Formula (aMDRD) and the Cockroft–Gault Adjusted for Body Surface (aCG) Equations in Stable Renal Transplant Patients and Living Kidney Donors

Abstract

The performance of abbreviated Modification of Diet in Renal Disease formula (aMDRD) and the Cockroft-Gault adjusted for body surface (aCG) equations as compared with measured 125 I-iothalamate glomerular filtration rate was analyzed in patients with stable renal transplantation (RTx) and in potential living kidney donors (LKD). One hundred and thirty-one patients had RTx and 150 were LKD. The paired t-test showed that the estimated glomerular filtration rate (GFR) values through the aMDRD and the corrected CG equations were significantly different from each other (p < 0.01). There were significant differences between GFRs estimated using aCG and aMDRD equations (p < 0.001) in both groups (RTx and LKD) of different ages. The Pearson correlation coefficient between aCG and aMDRD equations was good (0.77, p < 0.01), but the kappa coefficient was 0.39, indicating a low agreement between the two formulae. In RTx patients with GFR <60 mL/min/1.73 m 2 , the aMDRD equation performed better than the aCG formula with respect to bias (-0.6 vs. 3.0 mL/min/ 1.73 m 2 , respectively) and accuracy within 30% (72% vs. 56%, respectively) and 50% (91% vs. 73%, respectively). Similar results are reported for 48 diabetic RTx patients. In the LKD, the aMDRD equation significantly underestimated the measured GFR when compared with the aCG formula, with a bias of -8.0 versus 2.2 mL/min/1.73 m 2 , respectively (p < 0.05). We can conclude that the Cockroft and MDRD equations cannot be used interchangeably in clinical transplantation practice and in order to adjust drug doses.

A meta-analysis of renal outcomes in living kidney donors

“…Proteinuria is a well-known marker of disease progression. [17] In this meta-analysis, the estimated rate of ESRD in donors was approximately 1.0%, higher than 0.1% to 0.5% reported in previous studies. [5,18,19] In fact, a recent study has shown similar findings of increased risk of ESRD in LKDs.…”

Comparisons of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors (PCSK9I) versus Ezetimibe on Major Adverse Cardiovascular Events Amongst Patients with Dyslipidaemia: A Population-Based Study

“…The estimated glomerular filtration rate (eGFR) was calculated using the abbreviated modification of diet in renal disease (MDRD) formula. 19 The time-weighted lipid and glucose profiles were also calculated by the products of the sums of two consecutive measurements and the time interval, then divided by the total time interval, as suggested previously. 20…”

Compare SGLT2I versus non-SGLT2I users in type-2 diabetic mellitus patients on GLP-1 receptor agonist: A population-based and machine learning causal inference analysis

“…The estimated glomerular filtration rate (eGFR) was calculated using the abbreviated modification of diet in renal disease (MDRD) formula. [14] Furthermore, the time-weighted lipid and glucose profiles after drug initiation were also calculated by the products of the sums of two consecutive measurements and the time interval, then divided by the total time interval, as suggested previously. [15]…”