Comparison of a Within-Day Solid-Phase Immunoradiometric Assay With a Solution-Phase Radioimmunoassay for the Measurement of α-Fetoprotein in Amniotic Fluid
Abstract:l Summary: Using 231 amniotic fluid samples from a Regional Screening Service, the performance of a monoclonal antibody-based solid-phase immunoradiometric assay (IRMA) for α-fetoprotein was compared with that of a polyclonal antiserum-based solution phase radioimmunoassay (RIA). α-Fetoprotein values determined from these samples by the two methods were in excellent agreement (r = 0.992) and the diagnostic performance of the two assays was identical. However, the IRMA assay displayed a greater working r nge th… Show more
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