Comparison of a split-dose bowel preparation with 2 liters of polyethylene glycol plus ascorbic acid and 1 liter of polyethylene glycol plus ascorbic acid and bisacodyl before colonoscopy

Kang, Seung Hun; Jeen, Yoon Tae; Lee, Jae Hyung; Yoo, In Kyung; Kim, Seung Han; Choi, Hyuk Soon; Kim, Eun Sun; Keum, Bora; Lee, Hong Sik; Chun, Hoon Jai; Kim, Chang Duck

doi:10.1016/j.gie.2016.10.040

Cited by 27 publications

(30 citation statements)

References 11 publications

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“…Incidence of abdominal fullness, nausea, sleep disturbance and general discomfort was higher in the group treated with 1L PEG-Asc and oral bisacodyl than in the 2L PEG-Asc group, without statistical significance. 22 Similarly, Kwon et al 23 conducted bowel cleansing over 2 days in both groups and found that patients who consumed 1L PEG-Asc with oral bisacodyl complained more frequently than those in the 2L PEG-Asc group. These results might be attributed to the side-effects of bisacodyl, such as abdominal discomfort and sleep disturbance, when it is taken in the evening.…”

Section: Discussionmentioning

confidence: 98%

“…14,23 A few studies investigated bowel preparation prior to colonoscopy using 1L PEG-Asc with oral bisacodyl intake compared to 2L PEG-Asc. 22,23 In a study done by Kang et al, 22 bowel cleansing was carried out over 2 days, the day before and the day of the examination. Incidence of abdominal fullness, nausea, sleep disturbance and general discomfort was higher in the group treated with 1L PEG-Asc and oral bisacodyl than in the 2L PEG-Asc group, without statistical significance.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, several studies have been conducted to reduce the dosage of 2L PEG-Asc. 22,23 A recent study compared the quality of bowel cleansing and patient tolerability between a 2L PEG-Asc control group and 1L PEG-Asc and oral bisacodyl group before colonoscopy 22 and found no significant difference in bowel cleansing or tolerability between the groups. 22 Herein, we used a bisacodyl suppository to reduce the incidence of nausea, vomiting, and abdominal discomfort and avoid sleep disturbance through batch purging instead of split purging, as was observed following oral bisacodyl administration with 1L PEG-Asc in a previous study.…”

Section: Introductionmentioning

confidence: 99%

“…22,23 A recent study compared the quality of bowel cleansing and patient tolerability between a 2L PEG-Asc control group and 1L PEG-Asc and oral bisacodyl group before colonoscopy 22 and found no significant difference in bowel cleansing or tolerability between the groups. 22 Herein, we used a bisacodyl suppository to reduce the incidence of nausea, vomiting, and abdominal discomfort and avoid sleep disturbance through batch purging instead of split purging, as was observed following oral bisacodyl administration with 1L PEG-Asc in a previous study. 22 The present study aimed to compare the efficacy of bowel cleansing in the 2L PEG-Asc group and the group treated with 1L PEG-Asc with bisacodyl suppository, as well as to investigate complications and tolerability in the two groups.…”

Section: Introductionmentioning

confidence: 99%

“…22 Herein, we used a bisacodyl suppository to reduce the incidence of nausea, vomiting, and abdominal discomfort and avoid sleep disturbance through batch purging instead of split purging, as was observed following oral bisacodyl administration with 1L PEG-Asc in a previous study. 22 The present study aimed to compare the efficacy of bowel cleansing in the 2L PEG-Asc group and the group treated with 1L PEG-Asc with bisacodyl suppository, as well as to investigate complications and tolerability in the two groups. The optimal bowel-preparation method to reduce patient bowel-cleansing burden and improve accessibility to colonoscopy examination is presented.…”

Section: Introductionmentioning

confidence: 99%

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Combination of bisacodyl suppository and 1 L polyethylene glycol plus ascorbic acid is a non‐inferior and comfortable regimen compared to 2 L polyethylene glycol plus ascorbic acid

Kim

et al. 2019

Digestive Endoscopy

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Background and Aim: Appropriate bowel cleansing before colonoscopy is an important factor in increasing the detection rate of lesions. Low-volume polyethylene glycol (PEG) plus ascorbic acid (PEG-Asc) reduces the dosage of bowel preparation agent, but still presents discomfort to patients. The primary aim of the present study was to compare the efficacy of bowel cleansing between 2 L PEG-Asc (control) and 1 L PEG-Asc with bisacodyl suppository (suppository) groups, and the secondary aim was to investigate complications and tolerability between the two groups.Methods: This was a single-center prospective randomized controlled study. We identified 168 patients scheduled for colonoscopy between August 2017 and January 2018 and randomly assigned them to the control or to the suppository groups. Efficacy of bowel cleansing was assessed using the Boston Bowel Preparation Scale (BBPS), and side-effects were surveyed using questionnaires. Results: No significant difference was detected in baselinecharacteristics including insertion and withdrawal times, and adenoma detection rates between the two groups. Total BBPS score was 7.93 AE 1.06 and 7.74 AE 1.02 in the control and suppository groups, respectively (P = 0.22). Incidence of abdominal pain and nausea was not statistically different, whereas that of sleep disturbance and anal discomfort was higher in the control group. (P = 0.00). Conclusions:One liter PEG-Asc with bisacodyl suppository resulted in an equivalent bowel-cleansing outcome with reduced patient discomfort compared to 2 L PEG-Asc. Therefore, PEG-Asc with bisacodyl suppository represents a potential alternative and increases patient compliance with bowel preparation. Bowel Preparation Scale scores and complications associated with bowel preparations were recorded at Digestive Endoscopy 2020; 32: 600-607Suppository and 1 L polyethylene glycol 601

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Combination of bisacodyl suppository and 1 L polyethylene glycol plus ascorbic acid is a non‐inferior and comfortable regimen compared to 2 L polyethylene glycol plus ascorbic acid

Kim

et al. 2019

Digestive Endoscopy

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Efficacy of different bowel preparation regimen volumes for colorectal cancer screening and compliance with European Society of Gastrointestinal Endoscopy performance measures

et al. 2023

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Background Various volumes of bowel preparation are used in clinical practice. There is conflicting data on the effectiveness of individual regimens. This study aims to evaluate the efficacy and compliance of currently used bowel preparations with the European Society of Gastrointestinal Endoscopy (ESGE) performance measures using data of the Dutch nationwide colorectal cancer screening (CRC) program. Methods In a prospective, multicenter endoscopy database, we identified all CRC screening colonoscopies performed in 15 Dutch endoscopy centers from 2016 to 2020. We excluded procedures without documented bowel preparation or the Boston Bowel Preparation Scale (BBPS) score. Bowel preparation regimens were categorized into three groups, that is, 4‐L (polyethylene glycol (PEG)), 2‐L (2‐L PEG with ascorbic acid) and ≤1‐L volumes (sodium picosulfate with magnesium citrate, 1L‐PEG with sodium sulfate and ascorbic acid or oral sulfate solution). European Society of Gastrointestinal Endoscopy performance measures included adequate BBPS score (≥6) (>90%), cecal intubation rate (CIR, >90%), adenoma detection rate (ADR, >25%) and polyp detection rate (PDR, >40%). Logistic regression was performed to identify predictive factors for adequate BBPS and patient discomfort. Results A total of 39,042 CRC screening colonoscopies were included. Boston Bowel Preparation Scale scores, CIR, ADR and PDR for 4L, 2L and ≤1L regimens all met the minimum ESGE performance measures standards. However, an adequate BBPS score was more frequently seen with 2L regimens (98.0%) as compared to 4L (97.1%) and ≤1L regimens (97.0%) (p < 0.001), respectively. In addition, CIR was higher for ≤1L (98.4%) versus 4L (97.7%) and 2L (97.9%) regimens (p = 0.001), ADR higher for lower volume (≤1L (60.0%) and 2L (61.2)) versus higher volume (4L (58.6%)) regimens (p < 0.001), and PDR higher for ≤1L (70.0%) and 2L (70.8%) versus 4L (67.2%) regimens (p < 0.001). Boston Bowel Preparation Scale for ≤1L regimens was higher when combined with bisacodyl (97.3%) than without (95.6%) (p < 0.001). Overall, bisacodyl use was independently associated with higher patient discomfort (odds ratios = 1.47, confidence intervals = 1.26–1.72). Conclusions Despite variations in bowel preparation volumes, all regimens meet the minimum ESGE performance measures for bowel preparation and other quality parameters. Boston Bowel Preparation Scale can be further improved if ultra low volume regimens are combined with bisacodyl. The choice for either bowel preparation volume can therefore be based on volume‐tolerance and patient preference.

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Cleaning effect and tolerance of 16 bowel preparation regimens on adult patients before colonoscopy: a network meta-analysis

Sun

Yang

Wang

2023

Int J Colorectal Dis

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Comparison of a split-dose bowel preparation with 2 liters of polyethylene glycol plus ascorbic acid and 1 liter of polyethylene glycol plus ascorbic acid and bisacodyl before colonoscopy

Cited by 27 publications

References 11 publications

Combination of bisacodyl suppository and 1 L polyethylene glycol plus ascorbic acid is a non‐inferior and comfortable regimen compared to 2 L polyethylene glycol plus ascorbic acid

Combination of bisacodyl suppository and 1 L polyethylene glycol plus ascorbic acid is a non‐inferior and comfortable regimen compared to 2 L polyethylene glycol plus ascorbic acid

Efficacy of different bowel preparation regimen volumes for colorectal cancer screening and compliance with European Society of Gastrointestinal Endoscopy performance measures

Cleaning effect and tolerance of 16 bowel preparation regimens on adult patients before colonoscopy: a network meta-analysis

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