Comparison of a new metamizole formulation and carprofen for extended post-operative analgesia in dogs undergoing ovariohysterectomy

Pharmacokinetic profiles of the active metamizole metabolites after four different routes of administration in healthy dogs

“…The C max value of MAA after p.o. administration of MT, if normalized for the dose, was comparable to that shown in a previous study in dogs (Kalchofner Guerrero et al., ). However, although the Kalchofner Guerrero study does not report the PK parameters, the elimination phase of MAA seems slower than that in the present study.…”

“…It is likely due to the different MT formulation used: immediate release (present study) vs. new slow-release formulation (Kalchofner Guerrero et al, 2015). It is reported that the analgesic effect of MT correlates with plasma concentration of its two active metabolites (Nikolova et al, 2012).…”

“…However, although the Kalchofner Guerrero study does not report the PK parameters, the elimination phase of MAA seems slower than that in the present study. It is likely due to the different MT formulation used: immediate release (present study) vs. new slow‐release formulation (Kalchofner Guerrero et al., ).…”

“…MAA and AA are both active metabolites (Vlahov et al, 1990;Weithmann & Alpermann, 1985). In recent years, MT has experienced a revival for pain management in human and veterinary medicine, with pharmacokinetic studies being performed in food-producing animals and pharmacodynamics studies on dogs (Aupanun et al, 2016;Burmańczuk, Kowalski, Giorgi, Owen, & Grabowski, 2016;Giorgi et al, 2015;Giorgi et al, 2017;Imagawa et al, 2011;Kalchofner Guerrero et al, 2015;Schütter, Tünsmeyer, & Kästner, 2016;Teixeira et al, 2013;Zanuzzo et al, 2015).…”

“…In canine species, a single study only reports basic pharmacokinetics of MAA and AA after a single 50 mg/ kg p.o. administration of MT (KalchofnerGuerrero et al, 2015).The pharmacokinetic profiles of MAA after i.v. and i.m.…”