Comparison of a new laser beam wound camera and a digital photoplanimetry-based method for wound measurement in horses

Hecke, Lore L. Van; Mil, T.A. De; Haspeslagh, Maarten; Chiers, Koen; Martens, Ann

doi:10.1016/j.tvjl.2014.12.035

Cited by 8 publications

(5 citation statements)

References 16 publications

(23 reference statements)

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“…First, the methodology of theoretical margin comparisons only considered the horizontal plane. The depth measurements of the resulting tissue deficits were not recorded in the pivotal study, and while there are no true definitions of a "fascial plane" in the medical literature (13), future studies could explore this depth aspect of the mediated margins formed by intratumoural drugs by using digital planimetry commonly used in the assessment of wound healing (25)(26)(27)(28)(29). Second, the retrospective assessment of TTmediated margins also meant that small negative margins were calculated in nine cases, all with tumour volumes <1.1 cm 3 .…”

Section: Discussionmentioning

confidence: 99%

Tigilanol Tiglate-Mediated Margins: A Comparison With Surgical Margins in Successful Treatment of Canine Mast Cell Tumours

Ridder¹,

Reddell²,

Jones³

et al. 2021

Front. Vet. Sci.

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Tigilanol tiglate (TT) is a novel small molecule registered as a veterinary pharmaceutical for intratumoural treatment of canine mast cell tumours (MCTs). The drug has a multifactorial mode of action resulting in rapid destruction of the treated tumour by haemorrhagic necrosis and subsequent slough of the necrotic tumour to reveal a tissue deficit that is left to heal by second intention with minimal to no veterinary intervention. Here we introduce the concept of TT-mediated margins, the calculated margin of tissue loss analogous to surgically applied margins to help clinicians conceptualise tissue deficits formed following tumour destruction by TT relative to surgical excision. We used data from 51 dogs that were recurrence-free 12 months after a single administered TT dose into a single target MCT <10 cm3 in volume in a randomised, controlled clinical trial in the USA. We calculated TT-mediated margins based on length of the longest axis of (i) the tumour prior to treatment and (ii) the maximum tissue deficit formed 7–14 days after TT treatment. We compared these TT-mediated margins for each tumour to two surgical approaches to MCT excision in general practise: modified proportional margins (with 2 cm upper limit) and 3 cm fixed margins. For most dogs, TT-mediated margins were less than half the length of the margins calculated for the two surgical approaches in removing the same tumour. There was a trend for TT-mediated margins to increase with increasing tumour volume. Nonetheless, even for the larger tumours in this study (>2 cm3 volume), 50% of TT-mediated margins were less than half the length of the two surgical margins. Eighteen cases were lower limb MCTs, sites often surgically challenging in veterinary practise. On these lower limbs, TT-mediated margins were less than half the length of the corresponding proportional margins in 56% of cases and larger than proportional margins in only two cases. This study suggests that, in many cases, smaller and more targeted margins could be expected when treating MCTs <10 cm3 volume with TT compared with surgical excision. TT-mediated margins are a novel approach to conceptualise tissue deficits after intratumoural TT treatment.

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Section: Discussionmentioning

confidence: 99%

Tigilanol Tiglate-Mediated Margins: A Comparison With Surgical Margins in Successful Treatment of Canine Mast Cell Tumours

Ridder¹,

Reddell²,

Jones³

et al. 2021

Front. Vet. Sci.

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“…Weekly measurements of tumour thickness were performed in two horses (horses 3 and 4) that were affected by four sarcoids protruding above the level of surrounding unaffected skin ( n = 4). The mean of two measurements of the largest thickness in millimetres was recorded for each sarcoid. A laser beam wound camera (SilhouetteStar; ARANZ Medical) for surface area and circumference measurements 12 . Briefly, the camera was held perpendicular to the tumour surface, focusing the central point of the laser near or at the centre of the tumour.…”

Section: Methodsmentioning

confidence: 99%

“…A laser beam wound camera (SilhouetteStar; ARANZ Medical) for surface area and circumference measurements. 12 Briefly, the camera was held perpendicular to the tumour surface, focusing the central point of the laser near or at the centre of the tumour. Sarcoid dimensions were calculated using the accompanying software (SilhouetteConneCt; ARANZ Medical).…”

Section: Data Collectionmentioning

confidence: 99%

Longitudinal pilot study examining the effect of punch biopsy on equine sarcoid growth dynamics

Gysens,

Martens,

Haspeslagh

2024

Veterinary Dermatology

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BackgroundNonexcisional tissue biopsies facilitate pre‐operative confirmation of equine sarcoid yet fear of lesion deterioration currently limits its use in the diagnostic workup.ObjectivesTo evaluate the effect of a single punch biopsy on tumour growth dynamics [thickness, area, circumference, viral load (VL) and Visual Analog Scale (VAS)].AnimalsSix client‐owned horses with 11 sarcoids of various classification.Materials and MethodsGrowth dynamics were recorded on a weekly basis, 12 weeks pre‐ and 24 weeks post‐biopsy. The effect of a single punch biopsy on growth dynamics was estimated by linear mixed‐effect models. Spearman's rank correlation coefficient (SRCC) was calculated to investigate correlations with the number of weeks before and after the intervention.ResultsWhile statistically significant post‐biopsy changes were recorded for all parameters except VL, no parameter was consistently increased after the biopsy intervention. In two of 11 sarcoids, the VL correlation pattern revealed significant strong correlations: sarcoid 6 (pre: r = −0.66, p < 0.05; post: r = 0.81, p < 0.001), increased VL; and sarcoid 8 (pre: r = 0.85, p < 0.001; post: r = 0.17, p > 0.05), no further increase after biopsy.Conclusions and Clinical ImportanceOur results indicate that post‐biopsy lesion deterioration is not a general concept that applies to all sarcoids, and both deterioration or improvement are possible outcomes over a 24‐week period. Further clinical studies with a larger sample size are needed before a definitive conclusion can be made.

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“…To evaluate swelling, limb circumference was measured immediately distal to the proximal wound. Blood flow was evaluated indirectly using a thermographic camera (ThermaCam E2, FLIR Systems,) as described by Celeste et al 19 Wound dimensions (surface area and maximum depth) were measured using a laser beam camera (SilhouetteStar, ARANZ Medical, Christchurch, New Zealand) as described elsewhere 20 . To be able to compare the evolution of wound dimensions over time and between treatments, relative dimensions were calculated (eg, relative surface area (%) = surface area of the current measurement/ surface area of the initial wound).…”

Section: Methodsmentioning

confidence: 99%

Limited added value of negative pressure wound therapy compared with calcium alginate dressings for second intention healing in a noncontaminated and contaminated equine distal limb wound model

Haspeslagh

Hecke

Hermans

et al. 2021

Equine Veterinary Journal

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Background: Distal limb wounds in horses often show aberrant healing due to a slow inflammatory response. In human medicine, negative pressure wound therapy (NPWT) is used for the treatment of chronic wounds with a similar inflammatory response. Objectives:To compare the effect of NPWT to calcium alginate dressings on the healing of (non) contaminated equine distal limb wounds. Study design: Controlled experiment.Methods: Circular wounds were created on the left and right dorsomedial metacarpus of 10 horses. In five horses, the wounds were contaminated with Staphylococcus aureus and Pseudomonas aeruginosa. In all horses, one limb was treated with NPWT, the other with calcium alginate dressings. Treatments were applied during nine days for noncontaminated wounds and six days for contaminated wounds. Noninvasive (clinical assessment, bacteriology swabs, thermographic images and wound dimensions) and invasive (biopsies for histology and growth factor analysis) measurements were taken regularly for 71 and 29 days respectively. Effects of selected parameters on continuous dependent variables were analysed using ANOVA, while for discrete dependent variables, logistic regression was applied.Results: In noncontaminated wounds, there was significantly less wound retraction in the early healing stages when treated with NPWT (mean difference [95% CI] = 19.2% [13.3%-25.1%]; P = .005), although wound size was not significantly different between NPWT and control wounds at later healing stages. Noncontaminated control wounds had a significantly higher neutrophil influx (OR [95% CI] = 1.99 [1.49-2.66]; P < .001) and lower macrophage influx (OR [95% CI] = 0.75 [0.60-0.93]; P = .008) compared with NPWT-treated wounds. Bacterial load and the presence of growth factors did not differ between treatments in noncontaminated wounds. In contaminated wounds, no differences between treatments were observed in wound size, histological parameters, bacterial load or growth factor concentration.

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Comparison of a new laser beam wound camera and a digital photoplanimetry-based method for wound measurement in horses

Cited by 8 publications

References 16 publications

Tigilanol Tiglate-Mediated Margins: A Comparison With Surgical Margins in Successful Treatment of Canine Mast Cell Tumours

Tigilanol Tiglate-Mediated Margins: A Comparison With Surgical Margins in Successful Treatment of Canine Mast Cell Tumours

Longitudinal pilot study examining the effect of punch biopsy on equine sarcoid growth dynamics

Limited added value of negative pressure wound therapy compared with calcium alginate dressings for second intention healing in a noncontaminated and contaminated equine distal limb wound model

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