Comparison of a chemiluminescence immunoassay and an enzyme immunoassay for detection of IgM antibodies against measles, mumps, rubella, cytomegalovirus (CMV), Epstein Barr virus (EBV), and human herpes virus (HHV) -1 and -2 infections

Steve, Runal John; Mammen, Shoba; Selvaraj, Kavitha; Yadav, Bijesh; Abraham, Asha Mary

doi:10.1016/j.ijmmb.2022.06.001

Cited by 3 publications

(3 citation statements)

References 13 publications

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“…The determination of anti-HCMV antibodies in 1993 and 1999 was performed using the ELISA method in contrast to the CLIA technique used in our study. Nonetheless, several studies have established that both techniques are comparable [ 17 , 18 , 19 ]. Moreover, HCMV prevalence is lower in northern Europe than in southern regions [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Spanish HCMV Seroprevalence in the 21st Century

Álvarez-Heredia,

Reina-Alfonso,

Domínguez-del-Castillo

et al. 2023

Viruses

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Human cytomegalovirus (HCMV) is linked to age-related diseases like cardiovascular disease, neurodegenerative conditions, and cancer. It can also cause congenital defects and severe illness in immunocompromised individuals. Accurate HCMV seroprevalence assessment is essential for public health planning and identifying at-risk individuals. This is the first HCMV seroprevalence study conducted in the general Spanish adult population in 30 years. We studied HCMV seroprevalence and HCMV IgG antibody titres in healthy adult donors (HDs) and HCMV-related disease patients from 2010 to 2013 and 2020 to 2023, categorized by sex and age. We compared our data with 1993 and 1999 studies in Spain. The current HCMV seroprevalence among HDs in Spain is 73.48%. In women of childbearing age, HCMV seroprevalence has increased 1.4-fold in the last decade. HCMV-seropositive individuals comprise 89.83% of CVD patients, 69% of SMI patients, and 70.37% of COVID-19 patients. No differences in HCMV seroprevalence or HCMV IgG antibody titres were observed between patients and HDs. A significant reduction in Spanish HCMV seroprevalence among HDs was observed in 1993. However, women of childbearing age have shown an upturn in the last decade that may denote a health risk in newborns and a change in HCMV seroprevalence trends.

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Section: Discussionmentioning

confidence: 99%

Spanish HCMV Seroprevalence in the 21st Century

Álvarez-Heredia,

Reina-Alfonso,

Domínguez-del-Castillo

et al. 2023

Viruses

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“…Opportunistic infections with intraocular viruses are often secondary conditions in immunosuppressed patients-such as individuals with acquired immunodeficiency syndrome(AIDS) and posthaematopoietic stem cell transplantation patients [ 4 ]. Cytomegalovirus(CMV) retinitis is the most common complication in these patients [ 5 , 6 ]. CMV is a double-stranded DNA virus that is a member of the herpesvirus family [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Herpes viruses are usually divided into eight species. In addition to CMV, herpes simplex virus(HSV), varicella-zoster virus(VZV), and Epstein‒Barr virus(EBV) are also herpes viruses [ 6 ]. Retinitis caused by viruses other than CMV is uncommon in immunosuppressed patients, and mixed infections with multiple viruses are even rarer.…”

Section: Introductionmentioning

confidence: 99%

Retinitis after haematopoietic stem cell transplantation with multiple intraocular viral infections (cytomegalovirus, Epstein‒Barr virus and herpes simplex virus)- a case report

Liu,

He,

Zhang

et al. 2024

BMC Ophthalmol

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Background To report a case of retinitis with multiple intraocular viral infections after second haematopoietic stem cell transplantation. Case presentation A 39-year-old female patient developed retinitis after a second haematopoietic stem cell transplant. Right eye was tested for three viral infections– cytomegalovirus, Epstein‒Barr virus and herpes simplex virus, while left was infected with cytomegalovirus. The patient was subsequently treated with vitreous cavity ganciclovir injections, and 1 week later both eyes tested negative for aqueous humour viruses. Discussion and conclusion CMV, EBV and HSV belong to the herpes virus family. They are all commonly observed in the body and represent opportunity infectious viruses. The retinitis they cause have different characteristics. But simultaneous infection of the eye by multiple viruses is quite rare. In this case, three viruses were detected in the patient’s eye, but whether the retina was caused by all three viruses at the same time could not be determined. A satisfactory outcome was achieved after treatment with vitreous cavity ganciclovir injection.

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