Comparison of 9-hydroxy-artemisinin with artemisinin: interaction with bovine hemoglobin

Xiao, Mengsi; Yuan, Xiuxue; Xie, Wenli; Ge, Xuefeng; Zhou, Yecheng; Zhou, Lin; Zhou, Jiahong; Shen, Jian

doi:10.1016/j.jlumin.2014.12.002

Cited by 9 publications

(6 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Suppressors are mostly polymers such as polyethylene glycol (PEG), [16][17][18] triblock copolymers, 19 polypropylene glycol (PPG) [20][21][22] or diallylamine-type copolymers. 23 These polymers interact with chloride ions to inhibit copper deposition.…”

mentioning

confidence: 99%

Optimization of the Copper Plating Process Using the Taguchi Experimental Design Method

Hsu

Dow

Chang

et al. 2015

J. Electrochem. Soc.

View full text Add to dashboard Cite

Copper electroplating formulas composed of CuSO 4 , H 2 SO 4 , chloride ions, polyethylene glycol (PEG), bis (3-sulfopropyl) disulfide (SPS), and different levelers for microvia filling of a printed circuit board (PCB) were studied. The influence of the copper electroplating parameters, accelerator and leveler concentrations and cathodic current density on the microvia filling performance was explored using the Taguchi experimental design method. An L9 orthogonal array with four controlling factors at three levels was employed in the experimental design method. Variance analyses of the mean filling performance and the signal-to-noise ratio of the controlling factors showed that the most significant factor for the microvia filling performance was the leveler concentration. The other factors exhibited little to no effect on the microvia filling performance. The contribution of levelers to the filling performance was characterized using galvanostatic measurement and linear sweep voltammetry (LSV) with a working electrode at different rotational speeds. The experimental results indicated that the inhibiting effect of the levelers on the copper deposition was related to forced convection, which is a key physicochemical interaction for exhibiting good filling performance.

show abstract

mentioning

confidence: 99%

Optimization of the Copper Plating Process Using the Taguchi Experimental Design Method

Hsu

Dow

Chang

et al. 2015

J. Electrochem. Soc.

View full text Add to dashboard Cite

show abstract

“…As explained previously, the interaction between formetanate hydrochloride and Hb exposes hydrophobic patches on protein surfaces to the solvent (20). Reduction of the CD intensity in the presence of formetanate hydrochloride elucidated that the insecticide may be able to induce conformational changes in the secondary structure of Hb (21,22) Based on the results of thermodynamic parameters and the negative values of both ∆H° and ∆S°, it can be concluded that the binding process is enthalpy driven and the hydrogen bonds and van der Waals forces are involved in the binding reaction and complex stability. In addition, the negative amount of ∆G° confirms that the binding process is spontaneous (23).…”

Section: / Khatibi Sharifiyeh and Colleaguesmentioning

confidence: 77%

Investigating the Effects of Formetanate Hydrochloride on Human Hemoglobin by Spectroscopic Analysis and Molecular Docking Modeling

2019

View full text Add to dashboard Cite

Background and Objectives: Formetanate hydrochloride is an effective insecticide and acaricide, which is frequently used in citrus gardens. Given its high toxicity, it is necessary to evaluate effects of this insecticide on living factors. In this study, we investigate effects of formetanate hydrochloride on human hemoglobin using spectroscopic analysis and molecular docking modeling. Methods: Effects of formetanate hydrochloride on human hemoglobin were investigated using molecular docking technique and thermodynamic and spectrophotometric methods such as normal and synchronous fluorescence spectroscopy, UV-Vis absorption spectroscopy and circular dichroism. Results: Decrement of the soret band without any significant shift proved that the insecticide could penetrate into the heme pocket and directly interact with the porphyrin ring. Results obtained from the intrinsic fluorescence spectroscopy and heme degradation study at 321 and 460 nm indicated that formetanate hydrochloride could potentially destroy the heme prosthetic group and eliminate its filtering effect, which results in fluorescence enhancement. The fluorescence study demonstrated a competitive behavior between hydrophobic probe ANS and formetanate hydrochloride for binding to the hemoglobin hydrophobic patches. Results of circular dichroism and synchronous fluorescence spectroscopy confirmed the structural change and polarity alteration around aromatic fluorophores. Conclusion: Our findings elucidate that the binding of formetanate hydrochloride to hemoglobin through the heme pocket is energetically much more favorable compared to binding to the hydrophobic central cavity. In addition, formetanate hydrochloride can cause conformational changes in the human hemoglobin and the competitive behavior of this insecticide for the oxygen site can subsequently reduce the oxy form of hemoglobin.

show abstract

“…The far-UV CD curve of hemoglobin exhibited two negative peaks in the far-UVCD region at 208 nm and 222 nm, which refer to ᴨ→ᴨ* transition of the α-helix and n→ᴨ* transition for both the α-helix and random coil, respectively (31). Upon binding to each seven dyes, the CD spectrum of Hb diminished in magnitude, suggesting the decrease in the helical content of Hb.…”

Section: CDmentioning

confidence: 99%

“…Decreasing the fluorescence intensity indicates the increase of polarity around aromatic residues such as Trp and Tyr, meaning that this interaction led protein to unfolding states. Due to the decrease in values of the K sv and K q along with raising temperature, the nature of Hb fluorescence quenching found to be static because increasing the temperature resulted in increment of the molecular collisions in dynamic quenching; accordingly, the values of K sv and K q raised with temperature (6,31). Unfolding of Hb as a result of interaction with La and Acs was more displayed by the far-UV CD results, which demonstrated that all these ionic metals caused loss of helicity in the protein and led that into structural instability.…”

Section: CDmentioning

confidence: 99%

The impacts of some environmental pollutants and exogenous toxic ligands on conformational and functional properties of human hemoglobin: A systematic review of spectroscopic literature

Student)

Khatibi

2021

J Shahrekord Univ Med Sci

View full text Add to dashboard Cite

Background and aims: The objective of the present study was to collect the spectroscopic results obtained from previous studies to determine how exogenous toxic ligands can alter the structural and functional properties of human hemoglobin (HHb). Methods: Using spectroscopic techniques, English published articles (from January 2009 to June 2020) on HHb were systematical reviewed by searching several databases such as PubMed, ScienceDirect databases, and Google Scholar. In this regard, some keywords were searched, including (human hemoglobin) AND (spectroscopy) OR (spectroscopic analysis) OR (spectroscopic studies) AND (environmental pollutants) OR (food additives) OR (dyes) OR (fuel additives) OR (radioactive metal ions) OR (insecticides) OR (food colorants). After screening full text articles, we extracted relevant data according to our subject from included articles. Results: Finally, 17 studies were found to be related to the subject of this study. Analysis of investigations suggested that after exposure of HHb to each exogenous ligand, we could observe heme hydrophobic pocket alteration, fluorescence quenching, and polarity alteration around aromatic residues of protein, indicating that the structural properties of HHb were changing. Lack of some spectroscopic techniques in some articles could place some minor limitations on the obtained evidence. Conclusion: Considering the impacts of the exogenous ligands on characteristics of HHb, in the first step, it is the responsibility of governments to exercise strict control over the manufacturing sectors and then industry owners to investigate the effects of chemical products on the living organisms before commercializing them.

show abstract

Comparison of 9-hydroxy-artemisinin with artemisinin: interaction with bovine hemoglobin

Cited by 9 publications

References 34 publications

Optimization of the Copper Plating Process Using the Taguchi Experimental Design Method

Optimization of the Copper Plating Process Using the Taguchi Experimental Design Method

Investigating the Effects of Formetanate Hydrochloride on Human Hemoglobin by Spectroscopic Analysis and Molecular Docking Modeling

The impacts of some environmental pollutants and exogenous toxic ligands on conformational and functional properties of human hemoglobin: A systematic review of spectroscopic literature

Contact Info

Product

Resources

About