Comparison of 68Ga‐PSMA PET/CT and mp‐MRI in regard to local staging for prostate cancer with histopathological results: A retrospective study

Uçar, Taha; Gündüz, Nesrin; Demirci, Emre; Çulpan, Meftun; Gunel, Humeyra; Kır, Gözde; Atış, Ramazan Gökhan; Yıldırım, Asıf

doi:10.1002/pros.24420

Cited by 11 publications

(6 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…multiparametric magnetic resonance imaging for identifying intraprostatic index lesions, involving 40 patients correlated with prostatectomy. They reported a sensitivity of 42.5% and a specificity of 90.7% for PSMA PET in detecting intraprostatic index lesions [20]. In line with this, our study which systematically assessed various volumetric 68 Ga-PSMA PET parameters in both standard and early time PET images, demonstrated a correlation between 68 Ga-PSMA PET parameters and tumor aggressiveness, aligning with previous findings.…”

Section: Discussionsupporting

confidence: 91%

Predictive significance of intraprostatic volumetric parameters derived from early and standard time 68Ga-PSMA PET/CT images in newly diagnosed prostate cancer patients

Erdogan,

Tekce,

Koca

et al. 2024

Nuclear Medicine Communications

View full text Add to dashboard Cite

Objective To investigate the relationship between intraprostatic 68Ga-prostate-specific membrane antigen (PSMA) uptake values and volumetric parameters derived from early pelvic and standard-time whole-body 68Ga-PSMA PET/computed tomography (CT) images in untreated prostate cancer (PCa) patients, and to assess the predictive significance of these data in relation to disease prognosis, comparing them with the Gleason score, clinical risk classification and the presence of metastatic disease detected in 68Ga-PSMA PET/CT imaging. Methods Eighty-one newly diagnosed PCa patients underwent early phase pelvic imaging at the 5th minute and standard time whole-body imaging at the 60th minute. Various threshold values were used in intraprostatic delineations to compute maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), intraprostatic PSMA tumor volume and intraprostatic total lesion PSMA uptake. Correlations between early and standard time measurements, as well as changes in SUV parameters over time, were examined. The association of these values with Gleason score, clinical risk status (National Comprehensive Cancer Network), and metastatic disease was explored. Results SUVmax measurements from both early and standard time images distinguished all three groups (clinical risk scores, Gleason score and metastatic group), with standard imaging demonstrating statistical superiority in receiver operating characteristic analyses. Strong correlations were observed between early and standard-time PET parameters. Changes in intraprostatic SUVmax and SUVmean values over time did not exhibit predictive value. Conclusion Although intraprostatic PSMA PET parameters generally aligned at both early and standard times, parameters obtained from standard time images showed more robust correlations with clinical risk scores, Gleason score and metastasis status in newly diagnosed, untreated PCa patients.

show abstract

Section: Discussionsupporting

confidence: 91%

Predictive significance of intraprostatic volumetric parameters derived from early and standard time 68Ga-PSMA PET/CT images in newly diagnosed prostate cancer patients

Erdogan,

Tekce,

Koca

et al. 2024

Nuclear Medicine Communications

View full text Add to dashboard Cite

show abstract

“…Prostate hyperplasia is characterized by swelling of the prostate surface, an absence of a high T2w signal on the prostate surface, presumed to be between the prostate and the anus or between the prostate and the seminal vesicles, and a low T2w signal or a large signal in the seminal vesicles (12,13). Recent advances in positron-emission tomography (PET)/MRI scanner technology have demonstrated the possibility of combining metabolic/receptor information from PET with anatomical and functional imaging from MRI in a multimodal manner (14). While most of the studies on PET/MRI have been on restaging for PCa after treatment, diagnosis of the dominant lesion and characterization using PET/MRI has been an area of increasing interest in recent years, especially with the development of prostate-specific membrane antigen (PSMA) radio ligands (15).…”

Section: Resultsmentioning

confidence: 99%

Biparametric MRI for Local Staging of Prostate Cancer: Current Status and Future Applications

DELL’ATTI

2024

Anticancer Res

View full text Add to dashboard Cite

Background/Aim: Multiparametric magnetic resonance imaging (mpMRI) is the recommended modality for local staging of prostate cancer (PCa). The use of dynamic contrast-enhanced (DCE) imaging alone significantly improves staging performance. However, several studies have revealed that DCE imaging adds no extra benefit for PCa detection. Many authors observed benefits of performing prostate MRI without DCE, so called biparametric MRI (bpMRI), such as the elimination of the toxicity of gadolinium administration, reduction of examination time, costs and better accessibility. This narrative review describes the variety of imaging modalities inLocal staging of PCa with bpMRI utilization and its comparison to mpMRI. Materials and Methods: A search of medical databases was performed to find eligible articles using the following key words: "prostate cancer", "MRI", "multiparametric", "biparametric" and "staging". MEDLINE, Web of Science, PubMed and Google Scholar were used to search for eligible articles published in the past 5 years and compared the diagnostic accuracy of mpMRI and bp MRI in local staging of PCa. Results: A total of 48 articles were evaluated. Multiple systematic reviews used pooled data to compare the accuracy of biparametric and multiparametric examinations. However, all these studies advise caution on using pooled data for clinical practice, pointing to multiple sources of heterogeneity among the studies evaluated. Conclusion: Given the absence of prospective data comparing bpMRI and mpMRI, randomized, prospective, multicenter studies are encouraged. However, mpMRI is the recommended modality for local staging

show abstract

“…Gallium‐68 prostate‐specific membrane antigen (PSMA) positron emission tomography–computed tomography (PET/CT) is one of the most frequently researched methods for primary staging. Some studies found a comparable detection rate between 68 Ga PSMA PET/CT and multiparametric prostate MRI, some studies stated that PSMA PET/CT provides additional contribution in lesion detection 20,21 . In most recent comparative studies PSMA PET/MRI showed a better intraprostatic lesion detection rate than multiparametric prostate MRI 22,23 .…”

Section: Discussionmentioning

confidence: 99%

“…Some studies found a comparable detection rate between 68 Ga PSMA PET/CT and multiparametric prostate MRI, some studies stated that PSMA PET/CT provides additional contribution in lesion detection. 20,21 In most recent comparative studies PSMA PET/MRI showed a better intraprostatic lesion detection rate than multiparametric prostate MRI. 22,23 Due to studies demonstrating the high diagnostic value of PSMA PET/CT in primary local staging, whether it will contribute to the detection of lesions with cribriform architecture may be the subject of further 24 Among the strengths of our study, evaluation within a homogeneous group can be counted as the most important one.…”

Section: Discussionmentioning

confidence: 99%

The cribriform morphology impairs Gleason 7 prostate cancer lesion detection on multiparametric magnetic resonance imaging

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background Prostate multiparametric magnetic resonance imaging (mpMRI) is a useful tool for the detection of tumor lesions however, some clinically significant lesions are still missed. We determined whether the cribriform pattern has an effect on lesion detection in mpMRI. Methods We reviewed the single‐institution database of the patients who underwent mpMRI before radical prostatectomy. We included the patients only with the Gleason 7 final pathology of open radical prostatectomy with curative intent between 2016 and 2021. Prostatectomy mappings according to the 16‐sector map and cribriform patterns were re‐evaluated by two genitourinary pathologists. Prostate mpMRIs were read by two genitourinary radiologists. If the index and nonindex lesions in pathology mapping were matched with mpMRI as Prostate Imaging Reporting and Data System‐3 or higher, it was defined as detectable. We compared the detection rates of lesions with and without cribriform morphology. In regression analysis, we also assessed the factors affecting the detectability of prostate cancer lesions. Results A total of 120 patients and 157 lesions were included in our study. While 52 of 83 cribriform pattern positive lesions could be detected in mpMRI, 59 of 74 cribriform pattern negative lesions could be detected (62.7% vs. 79.7%, respectively, p = 0.019). The lesions were also distributed homogeneously according to diameters and analyzed separately. All lesions between 21 and 30 mm with the negative cribriform pattern were detected on mpMRI. However, only 77.8% of cribriform pattern positive lesions between 21 and 30 mm could be detected (p = 0.034). The Higher D'Amico risk group and the absence of cribriform morphology were independent predictors for the lesion detection on mpMRI. Conclusion The presence of cribriform pattern in Gleason 7 prostate cancer lesions decreases the lesion detection rate of mpMRI.

show abstract

Comparison of 68Ga‐PSMA PET/CT and mp‐MRI in regard to local staging for prostate cancer with histopathological results: A retrospective study

Abstract: Background: Imaging modalities are used to diagnose and clinical grading of clinically significant prostate cancer. In this study, 68Ga-PSMA PET/CT (PSMA) and multiparametric prostate MRI (mp-MRI) were compared in regard to locating intraprostatic tumor and locoregional staging.

Cited by 11 publications

References 12 publications

Predictive significance of intraprostatic volumetric parameters derived from early and standard time 68Ga-PSMA PET/CT images in newly diagnosed prostate cancer patients

Predictive significance of intraprostatic volumetric parameters derived from early and standard time 68Ga-PSMA PET/CT images in newly diagnosed prostate cancer patients

Biparametric MRI for Local Staging of Prostate Cancer: Current Status and Future Applications

The cribriform morphology impairs Gleason 7 prostate cancer lesion detection on multiparametric magnetic resonance imaging

Contact Info

Product

Resources

About