Comparison of [68Ga]Ga-DOTA-FAPI-04 and [18F] FDG PET/CT for the diagnosis of primary and metastatic lesions in patients with various types of cancer

Chen, Haojun; Pang, Yizhen; Wu, Jingxun; Zhao, Liang; Hao, Bin; Wu, Jing; Wei, Jihong; Wu, San Gang; Zhao, Long; Luo, Zun-Chang; Lin, Xiangtao; Xie, Chengrong; Sun, Long; Qi, Lin; Wu, Hua

doi:10.1007/s00259-020-04769-z

Cited by 380 publications

(487 citation statements)

References 29 publications

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“…The query returned 30 publications and no duplicates. During the screening of the records, six results were excluded due to being only a dataset [11], being a reply [12], presenting results of FAP-specific PET for IgG4-related disease [13][14][15], and focusing on FAP as a way to image cardiotoxicity [16]. During the screening of the full-text articles, 5 articles were excluded due to presenting a patient with tuberculosis [17], presenting solely preclinical results [18], being a letter to the editor [19,20] and presenting a patient with benign liver nodules [21].…”

Section: Resultsmentioning

confidence: 99%

“…Chen et al performed a comparison of FAP-specific to FDG PET that contained 4 glioma patients (2 GBM, 1 grade II glioma, 1 grade III glioma) and noted that while the absolute uptake was lower for FAP-specific PET, the tumor-to-background ratio was higher [12].…”

Section: Brainmentioning

confidence: 99%

“…Data on FAP-specific PET is still limited. While several publications contain at least one patient with breast cancer, no dedicated analysis for target volume delineation has been performed [12,26,32,36,37]. The biggest collective consisted of four patients (3 invasive ductal carcinomas, 1 invasive lobular carcinoma) analyzed by Chen et al who found that FAP-specific PET was able to detect more lymph node metastases than FDG PET in this small sample [25].…”

Section: Breastmentioning

confidence: 99%

“…For esophageal cancer, the biggest patient collective was analyzed by Chen et al and featured 5 squamous cell carcinomas [12]. In a publication by the same group on patients with inconclusive FDG PETs, FAP-specific PET detected an occult esophageal primary in a patient whose cancer was formerly classified as CUP.…”

Section: Upper Gastrointestinal Tractmentioning

confidence: 99%

“…Chen et al report an improved detection sensitivity for bone metastasis compared to FDG-specific PET and a high tracer uptake of sarcomas [12]. Other studies also noted the propensity of FAP-specific PET to detect previously unknown osseous lesions [27].…”

Section: Bonementioning

confidence: 99%

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Clinical Results of Fibroblast Activation Protein (FAP) Specific PET and Implications for Radiotherapy Planning: Systematic Review

Windisch

Zwahlen

Koerber

et al. 2020

Cancers

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Small molecules targeting fibroblast activation protein (FAP) have emerged as a new group of tracers for positron emission tomography (PET) in 2018. The purpose of this systematic review is therefore to summarize the evidence that has been gathered to date in patients and to discuss its possible implications for radiotherapy planning. The MEDLINE database was searched for the use of FAP-specific PET in cancer patients and the records were screened according to PRISMA guidelines. Nineteen studies were included. While dedicated analyses of FAP-specific PET for radiotherapy planning were available for glioblastoma, head and neck cancers, lung cancer, and tumors of the lower gastrointestinal tract, there is still very limited data for several epidemiologically significant cancers. In conclusion, FAP-specific PET represents a promising imaging modality for radiotherapy planning that warrants further research.

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Section: Resultsmentioning

confidence: 99%

Section: Brainmentioning

confidence: 99%

Section: Breastmentioning

confidence: 99%

Section: Upper Gastrointestinal Tractmentioning

confidence: 99%

Section: Bonementioning

confidence: 99%

See 3 more Smart Citations

Clinical Results of Fibroblast Activation Protein (FAP) Specific PET and Implications for Radiotherapy Planning: Systematic Review

Windisch

Zwahlen

Koerber

et al. 2020

Cancers

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⁶⁸ Ga‐FAPI, a Twin Tracer for ¹⁸ F‐FDG in the Era of Evolving PET Imaging

Manafi‐Farid

Divband

Amini

et al. 2023

Radiology‐Nuclear Medicine Diagnostic Imaging

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Magnetic Particle Imaging: From Tracer Design to Biomedical Applications in Vasculature Abnormality

Xie,

Zhai,

Zhou

et al. 2023

Advanced Materials

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Magnetic particle imaging (MPI) is an emerging non‐invasive tomographic technique based on the response of magnetic nanoparticles (MNPs) to oscillating drive fields at the center of a static magnetic gradient. In contrast with magnetic resonance imaging (MRI), which is driven by uniform magnetic fields and projects the anatomic information of the subjects, MPI directly tracks and quantifies MNPs in vivo without background signals. Moreover, it does not require radioactive tracers and has no limitations on imaging depth. This review first introduces the basic principles of MPI and important features of MNPs for advanced imaging sensitivity, spatial resolution, and targeted biodistribution. The latest research on optimized MPI tracers is reviewed based on their material composition, physical properties, and surface modifications. Since all the imaging benefits have led to a series of promising biomedical applications, we also discuss recent relational practices of MPI in vascular abnormalities, including cardiovascular and cerebrovascular systems, and cancers. Finally, some considerations of obstructions and recent progress closely related to the clinical translation of MPI are summarized to provide possible direction for future research and development.This article is protected by copyright. All rights reserved

show abstract

Comparison of [68Ga]Ga-DOTA-FAPI-04 and [18F] FDG PET/CT for the diagnosis of primary and metastatic lesions in patients with various types of cancer

Cited by 380 publications

References 29 publications

Clinical Results of Fibroblast Activation Protein (FAP) Specific PET and Implications for Radiotherapy Planning: Systematic Review

Clinical Results of Fibroblast Activation Protein (FAP) Specific PET and Implications for Radiotherapy Planning: Systematic Review

⁶⁸ Ga‐FAPI, a Twin Tracer for ¹⁸ F‐FDG in the Era of Evolving PET Imaging

Magnetic Particle Imaging: From Tracer Design to Biomedical Applications in Vasculature Abnormality

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Comparison of [68Ga]Ga-DOTA-FAPI-04 and [18F] FDG PET/CT for the diagnosis of primary and metastatic lesions in patients with various types of cancer

Cited by 380 publications

References 29 publications

Clinical Results of Fibroblast Activation Protein (FAP) Specific PET and Implications for Radiotherapy Planning: Systematic Review

Clinical Results of Fibroblast Activation Protein (FAP) Specific PET and Implications for Radiotherapy Planning: Systematic Review

68 Ga‐FAPI, a Twin Tracer for 18 F‐FDG in the Era of Evolving PET Imaging

Magnetic Particle Imaging: From Tracer Design to Biomedical Applications in Vasculature Abnormality

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Product

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⁶⁸ Ga‐FAPI, a Twin Tracer for ¹⁸ F‐FDG in the Era of Evolving PET Imaging