Comparison of 4- versus 5-day Co-Synch + controlled internal drug release (CIDR) + timed artificial insemination protocols in dairy heifers

Palomares, Roberto A.; Fishman, Heidi J.; Jones, Arthur L.; Ferrer, Maria S.; Jenerette, Mathews; Vaughn, Aimee

doi:10.1016/j.theriogenology.2015.05.021

Cited by 6 publications

(11 citation statements)

References 31 publications

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“…It is possible that the smaller ovulatory follicle size and longer interval to ovulation observed in the 4‐day treatment in the current study could explain the numerically lesser P/TAI previously reported in dairy (Palomares et al . ) and beef heifers (Fishman et al . ) treated with 4‐day CoSynch+CIDR compared with heifers submitted to the 5‐day protocol.…”

Section: Discussionmentioning

confidence: 99%

“…Sample size was calculated using Proc Power on the basis of the expected means E 2 concentration at TAI for each group (4.0 vs. 2.6 pg mL −1 ), the SDs (0.7 pg mL −1 ) of the means, with alpha = 0.05, and a statistical power of 90% (Palomares et al . ). A repeated measure analysis for a mixed generalized linear model was performed to compare the response variables follicular diameter and hormone (E 2 and LH) concentrations overtime (baseline on hour 0 after CIDR removal and the Scheffé method to adjust for multiple comparisons) and between treatments.…”

Section: Methodsmentioning

confidence: 97%

“…A Monday to Friday 4‐day Cosynch+CIDR protocol has been investigated in dairy heifers in an attempt to simplify the routine reproductive management (Palomares et al . ). Heifers treated with the 4‐day protocol showed an adequate P/TAI (55.0%) which was not statistically different from that observed in the 5‐day CoSynch+CIDR (63.3%).…”

Section: Introductionmentioning

confidence: 97%

“…Serum E 2 concentration at the time of AI (72 hours after CIDR insert removal) was greater ( P < 0.01) in the 4‐day CoSynch+CIDR treatment than in the 5‐day CoSynch+CIDR treatment, suggesting differences in the stage of follicular development and steroidogenic capacity between treatments (Palomares et al . ).…”

Section: Introductionmentioning

confidence: 97%

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Comparison of follicular development, timing of ovulation and serum progesterone, estradiol and luteinizing hormone concentrations in dairy heifers treated with 4‐ or 5‐day CoSynch + CIDR protocols

Fishman‐Holland

Stoskute

Ferrer

et al. 2019

Veterinary Medicine & Sci

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The use of 4‐day CoSynch + Controlled internal drug release (CIDR) + timed artificial insemination (TAI) in dairy heifers has resulted in adequate pregnancy rates compared with the 5‐day CoSynch + CIDR + TAI protocol. The objective of this study was to compare follicular growth, timing of ovulation and serum progesterone (P4), estradiol (E2) and luteinizing hormone (LH) concentrations in dairy heifers treated with modified 4‐ or 5‐day CoSynch + CIDR protocols (CIDR for 4 or 5 days, PGF2α at CIDR removal and GnRH + TAI 72 h later). Twelve cycling Holstein heifers were randomly assigned to either the 4‐ or 5‐day Co‐Synch+CIDR (n = 6/treatment) to receive an intravaginal insert CIDR® containing 1.38 g of P4 for 4 or 5 days, respectively. At CIDR removal, 25 mg of PGF2α was injected IM; 72 h after CIDR removal, heifers received 100 μg of GnRH IM and timed artificial insemination (TAI). Follicular growth and timing of ovulation were assessed using transrectal ultrasonography. Blood samples were collected at the time of CIDR insertion and at frequent time points after CIDR removal for determination of P4 (at TAI), E2 (every 12 h) and LH (every 6 h during the first and second day and every 2 h on the third day). Heifers in the 4‐day group had smaller follicles from CIDR insert removal to ovulation compared with heifers in the 5‐day treatment. Five of six heifers (83.3%) in the 4‐day treatment ovulated at 90–96 h post CIDR insert removal, whereas most heifers in the 5‐day treatment (4/6; 66.6%) ovulated at 84–90 h post CIDR insert withdrawal. Heifers in the 5‐day treatment reached greater peak LH concentration between 48 and 72 h after CIDR insert removal and lesser E2 concentration at TAI than heifers in the 4‐day treatment. In conclusion, heifers in the 4‐day treatment had smaller follicular diameter at 0, 30, 36, 42 and 48 h after CIDR insert removal, longer interval from CIDR insert removal to ovulation, greater E2 concentrations at TAI, and lesser peak LH concentration than heifers in the 5‐day treatment. These results represent a baseline for further studies to determine if prolonging the interval to TAI by 6 h in the 4‐day CoSynch+CIDR would improve pregnancy risk.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

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Comparison of follicular development, timing of ovulation and serum progesterone, estradiol and luteinizing hormone concentrations in dairy heifers treated with 4‐ or 5‐day CoSynch + CIDR protocols

Fishman‐Holland

Stoskute

Ferrer

et al. 2019

Veterinary Medicine & Sci

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“…Promising developments have been shown by reducing the time of keeping CIDR devices in the vagina to 4 [23] or 5 days [15,24], although estrus response and conception rates are not consistent even after the use of the standard 7-day CIDR regime [3,25,26] which could be due to environmental, management, breed and other factors. Yet, a recent report showed a similar pregnancy success when CIDR was maintained for 5 days, 6 days and 14 days in heifers [27].…”

Section: Introductionmentioning

confidence: 99%

Manipulation of Fertility in Crossbred Dairy Cattle Using Controlled Internal Drug Release Device Combined With Prostaglandin and Equine Chorionic Gonadotrophin

Mekonnin

Howie

Harlow³

et al. 2016

AVS

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Abstract:Simplifying and improving our understanding of the protocols for inducing or synchronizing estrus is important for improving management of dairy cattle. This study evaluated the estrus response and conception rate of crossbred (Holstein Friesian X Zebu) dairy cows (n=75) and heifers (n=47) assigned to a 10-day controlled internal drug release (CIDR) deviceprostaglandin F2-alpha (PGF2α) -equine chorionic gonadotrophin (eCG) based estrus synchronization protocol. Animals were assigned to three groups (a) anestrus (n=62), (b) repeat-breeders (n=11) and (c) silent estrus (n=46), according to their reproductive history, per rectal palpation, and progesterone concentrations determined by On-Farm enzyme-linked immunosorbent assays (ELISA) in milk (lactating cows) or serum (dry cows and heifers). For each animal, a CIDR device (containing 1.38g progesterone) was inserted into the vagina and allowed to remain in-situ for 10 days. On Day 8 after device insertion, a dose of 500µg of PGF2α was administered intramuscularly (IM). On Day 10 (device removal), 500 IU of eCG was given IM. Animals were inseminated or mated 48 and 72 hrs post device removal. Pregnancy was assessed 20-24 days post insemination by measurement of progesterone in milk/serum and pregnancy was confirmed by per rectal palpation and/or ultrasonography 44-90 days post insemination. Overall estrus response and conception rates were 97.5% and 78.3%, respectively, with no significant differences in parity, pre-treatment reproductive status and farming system (smallholder vs organized commercial farms). Conception rate after induced/synchronized estrus was 82.9% and 72.1% in cows and heifers, respectively, with an overall calving rate of 94.4%. In conclusion, the present study has shown high estrus response and conception rate in crossbred dairy cattle using this CIDR -PGF2α -eCG based estrus synchronization protocol. Application of this protocol is highly recommended to enhance fertility of dairy cattle in the study area, and this could readily be applied to other regions.

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The effect of GnRH administration/insemination time on follicular growth rate, ovulation intervals, and conception rate of Nili Ravi buffalo heifers in 7 –day-CIDR Co-synch

Haider

Chishti

Mehmood

et al. 2021

Trop Anim Health Prod

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The present study aimed to compare two different insemination times (72 vs 84 h) associated with an ovulation induction (GnRH) in a 7-day CIDR Co-synch to improve the conception rate of Nili Ravi buffalo heifers. Forty Nili Ravi buffalo heifers were randomly separated into two treatments based on artificial insemination (AI) timing (72 vs 84 h). All heifers were subjected to controlled internal drug release (CIDR), containing 1.38 g of progesterone for 7 days. On CIDR removal, both treatments received 150 µg of prostaglandin intramuscularly. In 7-day CIDR Co-synch (n = 20), animals were injected 100 µg of GnRH administration intramuscularly and inseminated concurrently at 72 h after CIDR removal. The remaining half (n = 20) were injected and inseminated concurrently at 84 h of CIDR removal. Pregnancy diagnosis was performed on day 40 of timed artificial insemination (TAI) with ultrasound. The follicular growth rate between 72 h after PGF 2α /CIDR removal to pre-ovulatory follicle in 7-day CIDR Co-synch was more (0.102 ± 0.005 mm vs 0.079 ± 0.003 mm; P = 0.01) at 84 than 72 h. The interval from GnRH administration/TAI to ovulation was high (26.8 ± 1.64 h vs. 15.1 ± 1.25 h, P = 0.01) in 72 than 84 h. Conception rates were considerably higher in buffalo heifers inseminated at 84 h (65%) than 72 h (25%) in 7-day CIDR Co-synch protocol. In conclusion that in Nili Ravi buffalo heifers, GnRH administration/TAI after 84 h of CIDR removal allows greater follicular growth rate and shortens interval from AI to ovulation compared to the GnRH administration/TAI after 72 h of CIDR removal in 7-day CIDR-Co-synch protocol.

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Comparison of 4- versus 5-day Co-Synch + controlled internal drug release (CIDR) + timed artificial insemination protocols in dairy heifers

Cited by 6 publications

References 31 publications

Comparison of follicular development, timing of ovulation and serum progesterone, estradiol and luteinizing hormone concentrations in dairy heifers treated with 4‐ or 5‐day CoSynch + CIDR protocols

Comparison of follicular development, timing of ovulation and serum progesterone, estradiol and luteinizing hormone concentrations in dairy heifers treated with 4‐ or 5‐day CoSynch + CIDR protocols

Manipulation of Fertility in Crossbred Dairy Cattle Using Controlled Internal Drug Release Device Combined With Prostaglandin and Equine Chorionic Gonadotrophin

The effect of GnRH administration/insemination time on follicular growth rate, ovulation intervals, and conception rate of Nili Ravi buffalo heifers in 7 –day-CIDR Co-synch

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