1989
DOI: 10.1016/0014-2999(89)90516-5
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Comparison of [3H]YM-09151-2 with [3H]spiperone and [3H]raclopride for dopamine D-2 receptor binding to rat striatum

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Cited by 125 publications
(46 citation statements)
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“…Nemonapride has a high affinity and selectivity for D 2 like receptors (Terai et al 1989); however, this drug is not selective for either D 3 or D 4 receptors over D 2 receptors . In contrast, YM-43611 exhibits moderate selectivity for D 3 receptors and high selectivity for D 4 receptors.…”
Section: Discussionmentioning
confidence: 99%
“…Nemonapride has a high affinity and selectivity for D 2 like receptors (Terai et al 1989); however, this drug is not selective for either D 3 or D 4 receptors over D 2 receptors . In contrast, YM-43611 exhibits moderate selectivity for D 3 receptors and high selectivity for D 4 receptors.…”
Section: Discussionmentioning
confidence: 99%
“…YM-43611 shifted the inhibition curve of dopamine on hD3 receptor-mediated cyclic AMP formation to the right; maximal inhibition was not affected by 100 nM YM-43611 (Figure 3). To assess more stringently the antagonistic properties of YM-43611 on hD2 and hD4 receptors, we performed Schild analyses using several YM-43611 concentrations (Figure 4) (Iwanami et al, 1981;Terai et al, 1989). In our studies on a series of benzamide derivatives, we found that varying 4-substituents on the benzamide could affect affinity and selectivity for the D2-like receptor subtypes (data not shown).…”
Section: Discussionmentioning
confidence: 99%
“…We previously developed a benzamide, nemonapride (YM-09151-2; Figure 1), which showed the pharmacological profile of a neuroleptic in in vivo studies (Iwanami et al, 1981;Usuda et al, 1981). Nemonapride has selectivity and potent affinity for D2-like receptors (Terai et al, 1989); in common with other neuroleptics, it is not selective for either D3 or D4 receptors over D2 receptors. In the search for a novel class of D2-like receptor ligands, we found ( Figure 1 Pharmacology (1996) 117,[1625][1626][1627][1628][1629][1630][1631][1632] Methods…”
Section: Introductionmentioning
confidence: 99%
“…Washed membranes were prepared from brain regions and were incubated with tritiated ligands as described (23)(24)(25)(26)(27)(28)(29)(30). Reactions were terminated by the addition of ice-cold buffered solutions as described (23)(24)(25)(26)(27)(28)(29)(30), and membrane-associated ligand estimated after rapid filtration over Whatman GF͞B filters using a Brandel apparatus. VMAT2, serotonin transporter, norepinephrine transporter, dopamine transporter, dopamine D 1 and D 2 receptor, serotonin 5HT 1 Measurement of Blood Pressure and Heart Rates.…”
Section: Methodsmentioning
confidence: 99%