Comparison of 3 different multianalyte point-of-care devices during clinical routine on a medical intensive care unit

Stadlbauer, Vanessa; Wallner, Simon; Stojaković, Tatjana; Smolle, Karl-Heinz

doi:10.1016/j.jcrc.2010.09.003

Cited by 20 publications

(22 citation statements)

References 15 publications

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“…Among the 21 selected studies [15-35], 11 studies [15-25] used ISO criteria, the error-grid method, or percentage of values within 20% of the error of a reference; three studies [26-28] used agreement with criteria other than these criteria, and seven studies [29-35] used only bias for evaluation (Figure 1, Table 1). …”

Section: Resultsmentioning

confidence: 99%

“…Bias was assessed for Glu-ABGs in five studies [15-18,20], for Gluco-C in 13 studies [18,20-27,29-31,33,34], and for Gluco-A in 12 studies [18,20-23,25,27,28,30-32,35]. The mean differences varied between -2.7 mg/dl [17] and 25.2 mg/dl [16] in Glu-ABGs, between -16 mg/dl [23] and 9.9 mg/dl [22] in Gluco-C, and between -10 mg/dl [23] and 23.0 mg/dl [32] in Gluco-A.…”

Section: Resultsmentioning

confidence: 99%

“…Limits of agreements were shown for Glu-ABGs in two reports [15,17], for Gluco-C in 10 studies [21-24,26,29-31,33,34], and for Gluco-A in seven studies [21-23,25,30-32,35]. Its range (upper limit to lower limit) varied between 19 mg/dl [15] and 39 mg/dl [17] for Glu-ABGs, between 44 mg/dl [26] and 144 mg/dl [29] for Gluco-C, and between 38 mg/dl [32] and 82 mg/dl [23] for Gluco-A.…”

Section: Resultsmentioning

confidence: 99%

“…Its range (upper limit to lower limit) varied between 19 mg/dl [15] and 39 mg/dl [17] for Glu-ABGs, between 44 mg/dl [26] and 144 mg/dl [29] for Gluco-C, and between 38 mg/dl [32] and 82 mg/dl [23] for Gluco-A.…”

Section: Resultsmentioning

confidence: 99%

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Accuracy of blood-glucose measurements using glucose meters and arterial blood gas analyzers in critically ill adult patients: systematic review

et al. 2013

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IntroductionGlucose control to prevent both hyperglycemia and hypoglycemia is important in an intensive care unit. Arterial blood gas analyzers and glucose meters are commonly used to measure blood-glucose concentration in an intensive care unit; however, their accuracies are still unclear.MethodsWe performed a systematic literature search (January 1, 2001, to August 31, 2012) to find clinical studies comparing blood-glucose values measured with glucose meters and/or arterial blood gas analyzers with those simultaneously measured with a central laboratory machine in critically ill adult patients.ResultsWe reviewed 879 articles and found 21 studies in which the accuracy of blood-glucose monitoring by arterial blood gas analyzers and/or glucometers by using central laboratory methods as references was assessed in critically ill adult patients. Of those 21 studies, 11 studies in which International Organization for Standardization criteria, error-grid method, or percentage of values within 20% of the error of a reference were used were selected for evaluation. The accuracy of blood-glucose measurements by arterial blood gas analyzers and glucose meters by using arterial blood was significantly higher than that of measurements with glucose meters by using capillary blood (odds ratios for error: 0.04, P < 0.001; and 0.36, P < 0.001). The accuracy of blood-glucose measurements with arterial blood gas analyzers tended to be higher than that of measurements with glucose meters by using arterial blood (P = 0.20). In the hypoglycemic range (defined as < 81 mg/dl), the incidence of errors using these devices was higher than that in the nonhypoglycemic range (odds ratios for error: arterial blood gas analyzers, 1.86, P = 0.15; glucose meters with capillary blood, 1.84, P = 0.03; glucose meters with arterial blood, 2.33, P = 0.02). Unstable hemodynamics (edema and use of a vasopressor) and use of insulin were associated with increased error of blood glucose monitoring with glucose meters.ConclusionsOur literature review showed that the accuracy of blood-glucose measurements with arterial blood gas analyzers was significantly higher than that of measurements with glucose meters by using capillary blood and tended to be higher than that of measurements with glucose meters by using arterial blood. These results should be interpreted with caution because of the large variation of accuracy among devices. Because blood-glucose monitoring was less accurate within or near the hypoglycemic range, especially in patients with unstable hemodynamics or receiving insulin infusion, we should be aware that current blood glucose-monitoring technology has not reached a high enough degree of accuracy and reliability to lead to appropriate glucose control in critically ill patients.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Accuracy of blood-glucose measurements using glucose meters and arterial blood gas analyzers in critically ill adult patients: systematic review

et al. 2013

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“…Previous analytical comparisons of blood-gas analyzers have shown that BE values strongly diff er between devices, especially due to the diff erence between calculation formulas, and that the reproducibility of BE measurements was not as good as those for arterial standard [HCO 3 2 ]. 2 Moreover, as referenced on the Westgard QC website, 3 within-and between-subject biologic BE variability is much larger than that of bicarbonate (76.4% and 43.2% compared with 4.0% and 4.8%, respectively), making the use of BE in early OHS somewhat questionable.…”

Section: Bicarbonate or Base Excess In Early Obesity Hypoventilation mentioning

confidence: 99%

Bicarbonate or Base Excess in Early Obesity Hypoventilation Syndrome

Monneret

2015

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Determination of Total PSA Using Magnetic Beads and a Re‐usable Screen Printed Carbon Electrode Array

2015

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[a] 1IntroductionProstate cancer accounts for 10 %o fa ll deaths from cancer [1,2] and the prostate specific antigen (PSA) is the best serumm arkerc urrently available for the preoperative diagnosis and screening for this cancer. PSA in serum circulates under two forms (free PSA(fPSA) [3] and complexed,b eing the predominanto ne the complex with a 1-antichymotripsin (PSA-ACT) [4].I np rostate cancer diagnosis,t he sum of both forms noted total PSA (tPSA) is used to determine somec ut off.Avalue of tPSA above 10.0 ng/mL is regardeda sp ositive and indicates high probability of prostate cancer;b elow 4.0 ng/mL the result is considered negativea nd indicatesl ow probability of prostate cancer;b etween 4.0 ng/mL and 10 ng/mLt he result is in the so-called "grey zone" [5].T he quantitative detection of PSA has been carried out using optical methods including fluorescent labeling [6,7],s urface enhanced Raman scattering (SERS) [8],s urface Plasmon resonance (SPR) [9],o relectrochemicalm ethods [10][11][12].Point-of-care testing (POCT)i sn ecessary and thus traditional techniques utilizing highly expensive, immovable analytical equipment such as gas Chromatography-Mass Spectrometers are not feasible for sensing outside the laboratories [13-17] Screen-printing is aw ell establish technique for the reliable fabrication of robust biosensors, due to its low cost and applicability to mass production. Screen-printed electrodes (SPEs) in particular can combine ease of use and portability with simple,i nexpensive screen-printedt echniques and nowadays it can be found different designsoft his device [18][19][20][21][22].Despite manye fforts have been made in developing sensors for PSA detection, many challenges still need to be addressed such as their miniaturization, simplification of the fabrication steps and cost reduction.Magnetic beads (MBs)are used in bioassay with the capability to increase surface area to improve sensitivity [23].M ore important, MBs are easy to manipulate with the help of magnet and make possible the biological reaction events could be performed awayf rom the electrode surface [24],e ffectively reducing the complexity and time required for sensing application. Their use minimizes matrix effect due to washing and separation procedures and, since the beads are in suspension, allows faster assay kineticst ob ea chieved [25].M oreoverM Bs can be easily functionalized with differentl inkageg roups uch as streptavidin [26][27][28],t osyl groups [29][30][31][32], amino groups [33][34][35],a ntibodies or proteins [36][37][38][39].T he only problem represented by the use of the MBsi st hat the recognition elementisnot in direct contact with the surface electrode. To avoid this and to achieve greater sensitivity,i th as been proposed the use of magnetized electrode surface through either the inclusion in the electrode material of magneticp articles [40] or through the placement of small magnets below the surface of the working electrode [41,42].T his allows concentrating the MBs on the electrode surface for t...

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Comparison of 3 different multianalyte point-of-care devices during clinical routine on a medical intensive care unit

Cited by 20 publications

References 15 publications

Accuracy of blood-glucose measurements using glucose meters and arterial blood gas analyzers in critically ill adult patients: systematic review

Accuracy of blood-glucose measurements using glucose meters and arterial blood gas analyzers in critically ill adult patients: systematic review

Bicarbonate or Base Excess in Early Obesity Hypoventilation Syndrome

Determination of Total PSA Using Magnetic Beads and a Re‐usable Screen Printed Carbon Electrode Array

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