Comparison of 2 days versus 5 days of octreotide infusion along with endoscopic therapy in preventing early rebleed from esophageal varices

Abstract

Two days of octreotide infusion following endoscopic therapy is sufficient and as efficacious as 5 days of infusion in preventing early rebleed, with reasonably better cost-effectiveness.

Second‐look endoscopy‐guided therapy under sedation prevents early rebleeding after variceal ligation for acute variceal bleeding

“…AVB at endoscopy was identified as an independent predictor of post‐EVL bleeding in several studies, which is in agreement with our results. However, it is not a predictor for mortality.…”

“…Our study is the first to show that SLE-guided PAO administration after the formation of post-EVL ulcers reduced early rebleeding and mortality rates in patients with AVB at index EVL, suggesting that the starting point and length of PAO administration are crucial. AVB at endoscopy was identified as an independent predictor of post-EVL bleeding in several studies, 7,19,[25][26][27] which is in agreement with our results. However, it is not a predictor for mortality.…”

“…Vasoconstrictors such as octreotide are recommended when AVB is suspected, with a continuous use for up to 5 days . A recent RCT has revealed that a 2‐day octreotide infusion following endoscopic therapy is as efficacious as a 5‐day infusion in preventing early rebleeding from EV . Current guidelines recommend PPI administration in cirrhotic patients with varices only when active peptic ulcer disease or active bleeding is presented .…”

“…[1][2][3][4][5][6] A recent RCT has revealed that a 2-day octreotide infusion following endoscopic therapy is as efficacious as a 5-day infusion in preventing early rebleeding from EV. 19 Current guidelines recommend PPI administration in cirrhotic patients with varices only when active peptic ulcer disease [1][2][3][4]6 or active bleeding is presented. 5 PPIs should be cautiously administered in patients with cirrhosis.…”

Інтенсивна Терапія Та Малоінвазивні Втручання В Комплексному Лікуванні Крово-Теч Із Варикозно Розширених Вен Стравоходу У Пацієнтів Із Декомпенсованим Цирозом Печінки

“…У світі налічується 2 мільярди людей, що є носіями вірусного гепатиту В або С -тобто кожен третій житель планети Земля. У 40-60% випадків вірусний гепатит В хронізується і спричинює цироз печінки, ускладнений портальною гіпертензією [5,6].…”