“…A large number of images with known truth is needed to provide reliable estimates of these quantities (Fukunaga and Hayes, 1989a, Kupinski et al, 2007, Ge et al, 2014). Furthermore, in large optimization and evaluation studies, task performance is assessed for many different combinations of system parameters and methods, such as different collimator designs (Yihuan et al, 2014, Ghaly et al, 2016), reconstruction methods and parameters (Frey et al, 2002, Gilland et al, 2006, He et al, 2006), and post-reconstruction filters and processing techniques (Frey et al, 2002, Sankaran et al, 2002). Thus, ensemble techniques require an enormous number of images to be obtained and stored; which often limits the number of parameters that can be explored.…”