Comparison of 17,641 Patients With Right- and Left-Sided Colon Cancer: Differences in Epidemiology, Perioperative Course, Histology, and Survival

Benedix, Frank; Kube, Rainer; Meyer, Frank; Schmidt, Uwe; Gastinger, I.; Lippert, H.

doi:10.1007/dcr.0b013e3181c703a4

Cited by 618 publications

(617 citation statements)

References 24 publications

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“…For colorectal cancer, no significant associations were found between NQO1 DOI:http://dx.doi.org/10.7314/APJCP.2013.14.4.2349 NQO1 C609T Gene Polymorphism andDigestive Tract Cancer: A Meta-analysis C609T polymorphism and colorectal cancer risk, but in the subgroup analysis by ethnicity; significant associations were observed for colorectal cancer in Caucasians, which was similar with previous meta-analysis study (Zhou et al, 2011;Chen et al, 2012). The reason may be that the different cancer sites had a dissimilar prevalence with a difference in clinical feature, prognosis and possibly in genetic and environmental epidemiology (Benedix et al, 2010); and the other reason may be the limited number of studies.…”

Section: Discussionsupporting

confidence: 82%

NAD(P)H: Quinone Oxidoreductase 1 (NQO1) C609T Gene Polymorphism Association with Digestive Tract Cancer: A Meta-analysis

Zhu

Huang²,

Liu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 82%

NAD(P)H: Quinone Oxidoreductase 1 (NQO1) C609T Gene Polymorphism Association with Digestive Tract Cancer: A Meta-analysis

Zhu

Huang²,

Liu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…5 The vast majority of the body of evidence is based on the leftright dichotomy in outcomes that was proposed over two decades ago. 6 Most of this research was aimed at site-specific (disease-free) survival, baseline characteristics and staging, and only rarely focusing specifically on patterns of metastasis: 7 using this left-right dichotomy, a German multicenter study demonstrated higher rates of pulmonary and liver metastasis in left-sided tumors, 8 on the other hand however, a Japanese study covering a single-center cohort of 820 patients could not identify significant differences in sites of metastasis. 9 There are several possible explanations for the differences in metastatic patterns identified here.…”

Section: Discussionmentioning

confidence: 99%

Variations in Metastasis Site by Primary Location in Colon Cancer

Amri

Bordeianou

Sylla

et al. 2015

Journal of Gastrointestinal Surgery

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In primary tumors of the colon, the presence of locoregional and distant metastasis has important consequences for the prognosis and the preferred treatment approach for the individual patient. 1 In the absence of clinical and radiological suspicion of distant metastasis, treatment will be surgical with curative intent in virtually all cases. If lymphatic disease is also absent in the surgical resection specimen, adjuvant therapy is rarely required and most patients will only need regular follow-up to monitor recurrence.Colonic malignancies have a tendency to spread to the pericolic lymphatics, followed by more distant lymph node stations, with distant hematologic spread usually seen as a last stage of dissemination. These steps are however not obligatorily sequential, nor is lymphatic spread a prerequisite of distant metastasis, as hematologic spread can occur in the absence of involved lymph nodes, even in necropsies. 2 Distant metastatic spread is present in about one in five patients at baseline, 3 most often to the liver, followed by the lungs and the peritoneum. Less typical sites of metastasis once colonic tumor cells reach the systemic arterial circulation are numerous and include the bones and bone marrow, the brain, and more rarely other parts of the gastrointestinal tract, as well as other solid organs including the kidney, the spleen, and adrenal glands.Despite being studied in detail, most of the research aimed at identifying patterns of metastasis combine patients affected by cancers of the colon and rectum. 4 If colonic malignancies are studied separately, it will commonly be done by clustering all regions of the colon together.Considering that lymphovascular drainage passes through distinct and anatomically discrete vessels for right-sided, left sided and sigmoid tumors, it could potentially have a significant impact on the specific rates and patterns of metastatic spread. Our aim in this study is to verify whether metastasis patterns differ for each of the major resection regions in malignancies of the colon.

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“…For instance, we did survival analysis by cancer type (n=228, cancer type: colorectal adenocarcinoma, cancer type The site and subtype of cancer, and the prognosis of patients depend on gender, stage, race etc [12][13][14][15][16][17]. For these reasons, subgroup analysis is required to identify stage-and genderspecific prognostic genes.…”

Section: Survival Analysis By Mrna or Cancer Typementioning

confidence: 99%

GIANT: an online resource for comprehensive survival analysis in pan-cancer from The Cancer Genome Atlas (Preprint)

Han¹,

Goh²,

Jeong³

et al. 2018

Preprint

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Comparison of 17,641 Patients With Right- and Left-Sided Colon Cancer: Differences in Epidemiology, Perioperative Course, Histology, and Survival

Cited by 618 publications

References 24 publications

NAD(P)H: Quinone Oxidoreductase 1 (NQO1) C609T Gene Polymorphism Association with Digestive Tract Cancer: A Meta-analysis

NAD(P)H: Quinone Oxidoreductase 1 (NQO1) C609T Gene Polymorphism Association with Digestive Tract Cancer: A Meta-analysis

Variations in Metastasis Site by Primary Location in Colon Cancer

GIANT: an online resource for comprehensive survival analysis in pan-cancer from The Cancer Genome Atlas (Preprint)

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