Comparison of 10% potassium hydroxide solution versus cryotherapy in the treatment of molluscum contagiosum: An open randomized clinical trial

Handjani, Farhad; Behazin, Ebrahim; Sadati, Maryam Sadat

doi:10.3109/09546634.2013.832135

Cited by 33 publications

(16 citation statements)

References 9 publications

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“…Burning sensation or stinging during application was the most common side effect of KOH in previous studies, similar to this study, 7,9,14,20 while others have also noted erythema and crusting, 20 hyperpigmentation, 10,17 and hypopigmentation. 12, 13 Short reported both stinging (20%) and hyperpigmentation (20%) as the most common side effects. 21 A secondary infection with prolonged treatment, 7,17 hypertrophic scar, 17 ulceration, 12,14,19,22 erythema, 9,12,14,15,19 pruritus, 9,12,14 desquamation, 9,12,14,15,19 hypopigmentation, 13,14,17 and hyperpigmentation 9,13,17,19 are other side effects of KOH in the treatment of MC reported in the literature.…”

Section: Side Effects Of Therapiesmentioning

confidence: 98%

“…Hypopigmentation was the most common side effect in two studies from Iran and India. 12,13 The skin phototypes were not specified in these studies. The participants in these countries may most likely have dark skin color, mostly with Fitzpatrick skin phototypes 3 and 4.…”

Section: Side Effects Of Therapiesmentioning

confidence: 99%

“…[4][5][6] Keratolytic solutions act by dissolving the keratin, causing local destruction of the skin. 7 Previous studies have shown the efficacy of KOH in the treatment of MC, in various concentrations and comparisons with other treatments since 1999 [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] as well as topical SAL preparations. 9,15,22,23 There are only two studies that have assessed efficacy of KOH in comparison with SAL in fair skinned children with MC.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy and Side Effects of Topical Applications of Two Different Solutions in the Treatment of Molluscum Contagiosum in a City in Africa: An Open, Randomized, Comparative Clinical Trial

Öztürk

2019

J Pediatr Infect Dis

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Molluscum contagiosum (MC) is one of the most common viral infections in African children. However, there is no work investigating the treatment of MC in dark skinned children in Africa. In this study, we aimed to compare efficacy and side effects of topical application of 10% potassium hydroxide (KOH) and 16.7% salicylic acid (SAL) and lactic acid (LAC) combination in the treatment of MC in Sudan, Africa. This is a prospective, randomized, and comparative study. The inclusion criterion was the presence of at least 10 lesions. The exclusion criteria were the use of any topical MC treatment during the last 2 weeks, immunosuppression, periorbital and perioral involvement, the history of hypersensitivity to any kind of keratolytics, and the presence of concomitant bacterial skin infections. The main efficacy outcome was the complete remission or partial remission. Three visits were performed: baseline visit (diagnosis, randomization, and therapy initiation), visit 1 for follow-up (at 15–30 days after initiation of therapy and for study end), and visit 2 for postclearing assessment (at 60th day after the initiation of therapy). Chi-squared (χ2) test was used. All patients (n = 101) participating completed the 60 days of follow-up period. Post 60 days of treatment, the rates of complete resolution in 55 patients treated with 10% KOH solution and 47 patients treated with 16.7% SAL + LAC combination solution were 87.0 and 85.1% (p > 0.05), respectively. The rates of partial resolution in the group treated with KOH solution and in patients treated with SAL + LAC combination solution were 12.9% and 14.8% (p > 0.05), respectively. Major side effects in KOH group were burning sensation or stinging during application (48.1%, p = 0.0009) and hypopigmentation (38.8%, p = 0.007) while it was desquamation (23.4%, p > 0.05) in the SAL + LAC combination group. Results indicate both 10% KOH solution and SAL + LAC combination solution showed good efficacy in the treatment of MC in African children. Neither 10% KOH nor the SAL + LAC combination solution was found superior to other in the treatment, while the latter was noted to have fewer side effects. Permanent hypopigmentation is an important and undesired side effect of 10% KOH treatment.

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Section: Side Effects Of Therapiesmentioning

confidence: 98%

Section: Side Effects Of Therapiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efficacy and Side Effects of Topical Applications of Two Different Solutions in the Treatment of Molluscum Contagiosum in a City in Africa: An Open, Randomized, Comparative Clinical Trial

Öztürk

2019

J Pediatr Infect Dis

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“…Both forms of treatment appear to have similar efficacy in children, but cryotherapy may be associated with postinflammatory hyperpigmentation or, uncommonly, scarring. 99,100 Imiquimod was not shown to be of benefit compared with placebo in randomized controlled trials. 101,102 Open-label and observational studies 103,104 indicate that cantharidin can be an effective treatment of molluscum contagiosum; however, in 1 small randomized controlled trial of 29 patients, the improvement seen with cantharidin, although greater than with placebo, was not found to be statistically significant.…”

Section: Management Of Molluscum Outbreaksmentioning

confidence: 99%

Infectious Diseases Associated With Organized Sports and Outbreak Control

2017

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Participation in organized sports has a variety of health benefits but also has the potential to expose the athlete to a variety of infectious diseases, some of which may produce outbreaks. Major risk factors for infection include skin-to-skin contact with athletes who have active skin infections, environmental exposures and physical trauma, and sharing of equipment and contact with contaminated fomites. Close contact that is intrinsic to team sports and psychosocial factors associated with adolescence are additional risks. Minimizing risk requires leadership by the organized sports community (including the athlete's primary care provider) and depends on outlining key hygiene behaviors, recognition, diagnosis, and treatment of common sports-related infections, and the implementation of preventive interventions.

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“…Also, 5% potassium hydroxide has been compared with 0.05% tretinoin cream;13 and 10% potassium hydroxide with salicylic acid plus lactic acid;14 cryotherapy;15 and imiquimod;16 all the trials were open-label with small numbers of patients (26-50 participants). No one treatment showed a clear benefit.…”

Section: About Potassium Hydroxidementioning

confidence: 99%

Potassium hydroxide 5% for the treatment of molluscum contagiosum

2014

DTB

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Molluscum contagiosum is a common reason for consultation in primary care. The condition is normally benign and self-limiting1 and the standard advice is to wait for the lesions to resolve spontaneously.2 Recently, potassium hydroxide 5% (MolluDab-Alliance Pharmaceuticals Limited) has been marketed in the UK for the treatment of the condition.3 It is sold as a medical device rather than a licensed medicinal product. Here we consider the evidence for potassium hydroxide 5% in the management of molluscum contagiosum.

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Comparison of 10% potassium hydroxide solution versus cryotherapy in the treatment of molluscum contagiosum: An open randomized clinical trial

Abstract: Both treatment modalities were equally effective. Since KOH is inexpensive and confers better cosmetic results compared to cryotherapy, it can be used as a suitable treatment modality for MC.

Cited by 33 publications

References 9 publications

Efficacy and Side Effects of Topical Applications of Two Different Solutions in the Treatment of Molluscum Contagiosum in a City in Africa: An Open, Randomized, Comparative Clinical Trial

Efficacy and Side Effects of Topical Applications of Two Different Solutions in the Treatment of Molluscum Contagiosum in a City in Africa: An Open, Randomized, Comparative Clinical Trial

Infectious Diseases Associated With Organized Sports and Outbreak Control

Potassium hydroxide 5% for the treatment of molluscum contagiosum

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