Comparison of 1% and 2% lidocaine epidural anaesthesia combined with sevoflurane general anaesthesia utilizing a constant bispectral index

Abstract

To maintain BIS of 40-50 during combined epidural/general anaesthesia for lower abdominal surgery, sevoflurane concentrations were lower and less variable with lidocaine 2% than with 1%. In addition, the larger concentration of lidocaine suppressed the stress hormone responses better.

Benefits of intravenous lidocaine on post-operative pain and acute rehabilitation after laparoscopic nephrectomy

“…Lidocaine significantly reduced morphine consumption (median [25-75% interquartile range]; 8.5 mg[4567891011121314151617] vs. 25 mg[1920212223242526272829303132]; P < 0.0001), post-operative pain scores ( P < 0.05) and hyperalgesia extent on post-operative day 1-day 2-day 4 (mean ± standard deviation (SD); 1.5 ± 0.9 vs. 4.3 ± 1.2 cm ( P < 0.001), 0.6 ± 0.5 vs. 2.8 ± 1.2 cm ( P < 0.001) and 0.13 ± 0.3 vs. 1.2 ± 1 cm ( P < 0.001), respectively). Time to first flatus (mean ± SD; 29 ± 7 h vs. 48 ± 15 h; P < 0.001) and 6MWT at day 4 (189 ± 50 m vs. 151 ± 53 m; P < 0.001) were significantly enhanced in patients with i.v.…”

“…morphine given as titration in the PACU were 0 and 6 mg [0-9] in the Lidocaine and Reference groups respectively ( P < 0.001). Median cumulative morphine consumption at the end of post-operative day 2 was 8.5 mg [4-17] in the Lidocaine group and 25 mg[1920212223242526272829303132] in the Reference group ( P < 0.0001) [Figure 1]. Pain intensity was significantly reduced in the Lidocaine group both at rest and during coughing ( P < 0.0001) throughout the 48-h study [Figure 2].…”

Effect of Preoperative Epidural Morphine Administration on Desflurane Requirements During Gynecologic Surgery

“…It has been shown that epidural administration of 15 mL of 2% lidocaine reduced by 34% the sevoflurane required for adequate depth of anesthesia. 6 Shono et al 13 showed that 2% lidocaine rather than 1% lidocaine administration has resulted in both better control of the surgical stress response and significantly more sevoflurane-sparing effect when sevoflurane concentration was titrated according to BIS values. It is suggested that the intensity and extent of epidural block also has influence on inhalational anesthetic requirement.…”

Intravenös verabreichtes Lidocain zur perioperativen Schmerztherapie

“…Wird Lidocain für periphere Nervenblockaden oder zur Periduralanästhesie verwendet, werden in der Regel Plasmakonzentrationen von 3-5 µg/ml erreicht [17,34]. Toxizitätszeichen können ab einem Plasmaspiegel von 5 µg/ml auftreten, werden jedoch eher beobachtet, wenn Plasmaspiegel von mehr als 10 µg/ml erreicht werden.…”