Comparison GnRH agonist short protocol and GnRH antagonist in Brazilian normoresponder patients undergoing their first cycle of controlled ovarian stimulation

Arruda, Jalsi Tacon; Approbato, Mário Silva; Maia, Mariana; Silva, Tatiana Moreira da; Mendonça, Carolina Rodrigues; Ramos, Marisa de Sousa; Rodrigues, Shirley Ribeiro; Brito, Maria Zélia Pires; Aguiar, Coracy Coelho de

doi:10.5935/1518-0557.20130070

Cited by 2 publications

(2 citation statements)

References 24 publications

(45 reference statements)

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“…As demonstrated in this study, there is no difference in oocytes retrieval between these two protocols in recent meta analysis ( Tehraninejad et al , 2010 ; Bodri et al , 2011 ; Pu et al , 2011 ; Casano et al , 2012 ; Pundir et al , 2012 ) and randomized controlled trials ( Loutradis et al , 2004 ; Xavier et al , 2005 ; Kurzawa et al , 2008 ; Tazegul et al , 2008 ). Differently, some reports showed a less number of oocyte retrieval in the antagonist protocol ( Barmat et al , 2005 ; Arruda et al , 2013 ; Orvieto & Patrizio, 2013 ). Our results could be discussed in another way when we decide to use minor dose of gonadotropin.…”

Section: Discussionmentioning

confidence: 89%

“…After corrected by age, our study shows a minor dose of uFSH in antagonist protocol, but with no significant difference when compared to agonist protocol. Some reports evidence that a less amount of uFSH is needed in antagonist protocol (Kurzawaa et al, 2008;Tazegul et al, 2008;Lainas et al, 2010;Tehraninejad et al, 2010;Pundir et al, 2012;Arruda et al, 2013) and other papers shows no difference between protocols (Barmat et al, 2005;Bodri et al, 2011). The small need of uFSH determine a more friendly stimulation with less risk of OHSS and a greater compliance of our patients in treatment.…”

Section: Discussionmentioning

confidence: 99%

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Ovarian stimulation with GnRH analogues

Montenegro¹,

Faller²,

Almeida³

et al. 2014

JBRA Assisted Reproduction

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Objective: Analysis and compare data between two induction protocols (long agonist and flexible antagonist) in patients submitted an assisted reproduction technique in Porto Alegre. Methods: Cross-sectional study comparing the intermediate results with the use of two different ovarian stimulation protocols with gonadotropin-releasing hormone agonist versus antagonist to assisted reproductive techniques. The statistical analysis of the retrieved data (age, body mass index, number of oocytes recovered, number of fertilized oocytes, number of oocytes cleaved, total dose of FSH used and ovarian hyperstimulation syndrome) was performed by Student's t-test for parametric data and analysis of covariance for the dependent variables. Results: A total of 50 patients, 25 in each group, met the criteria for inclusion in the study between January and March in the year 2010. There was statistically significant difference only in the middle ages between the groups (P = 0.031). There was no statistical difference for the remaining data analyzed (body mass index, number of oocytes recovered, number of fertilized oocytes, number of oocytes cleaved and dose of FSH utilized). There were no cases of ovarian hyperstimulation syndrome. Conclusion: Both protocols are equal in terms of results. The agonist has advantages about scheduling of the procedure, but it takes too long to start the stimulation and have possibility to start medication in a pregnant patient. Added to this, we have the possibility of getting the ovarian hyperstimulation syndrome as complication. In the antagonist group, is clear the ease-of-use of the medication and the fastest start of stimulation.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Ovarian stimulation with GnRH analogues

Montenegro¹,

Faller²,

Almeida³

et al. 2014

JBRA Assisted Reproduction

View full text Add to dashboard Cite

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The Clinical Significance of A Low Percentage of Mature Oocytes Retrieved Using Common Ovarian Stimulation Protocols.

Więsak

Milewski

Somkuti

2017

JFB

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The objective of this study was to investigate whether percentage of mature oocytes retrieved from ovaries stimulated with long agonist or multi-dose antagonist protocols affect the implantation, clinical pregnancy and live birth of ICSI (Intracytoplasmic sperm injection) cycles. The 654 cycles of agonist (long lupron) and 610 cycles of multi-dose flexible antagonist (antagon) were analyzed after stratification according to the percentage of the mature oocytes retrieved. The clinical pregnancy of the groups with less than 30 % mature oocytes retrieved, both antagonist and agonist protocol was statistically lower (at least p< 0.05) compared to the groups with more than 30% mature oocytes retrieved. In the agonist protocol, the implantation and live births for this group were significantly (p<0.009) lower than in the group with ≥70% mature oocytes retrieved. The live births in groups with more mature oocytes retrieved (30-69% and ≥70 %) of the antagonist protocol were lower (22.2% vs. 35.9% and 23.9% vs. 41.5%, p<0.0001, respectively) compare to the agonist protocol.The results of our study showed that a very low percentage of mature oocytes retrieved impacts the clinical outcome of antagonist and long agonist protocols.

show abstract

Comparison GnRH agonist short protocol and GnRH antagonist in Brazilian normoresponder patients undergoing their first cycle of controlled ovarian stimulation

Cited by 2 publications

References 24 publications

Ovarian stimulation with GnRH analogues

Ovarian stimulation with GnRH analogues

The Clinical Significance of A Low Percentage of Mature Oocytes Retrieved Using Common Ovarian Stimulation Protocols.

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