Comparison between VII-to-VII and XII-to-VII coaptation techniques for early facial nerve reanimation after surgical intra-cranial injuries: a systematic review and pooled analysis of the functional outcomes

Ricciardi, Luca; Stifano, Vito; Pucci, Resi; Stumpo, Vittorio; Montano, Nicola; Monaca, Marco Della; Lauretti, Liverana; Olivi, Alessandro; Valentini, Valentino; Sturiale, Carmelo Lucio

doi:10.1007/s10143-019-01231-z

Cited by 10 publications

(7 citation statements)

References 73 publications

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“…Standard reconstructive techniques use autograft for filling the gap between the proximal stump and the distal nerve in facial nerve reanimation[ 4 ]. Studies have shown that autograft use tend to be superior to acellular grafts in these cases, in which sensory nerves are considered as the gold standard graft for motor nerves reconstruction[ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…Nerve fibers regenerate 1mm per day in humans, which is assumed to be similar with regrowth rates in animals. Reinnervation may occur within up to 12 mo in patients undergoing surgery for facial reanimation[ 4 ]; therefore, data on reinnervation should be carefully interpreted, especially if based on short follow-up observation times. Limiting results with stem cells may be due to short healing time assessments as opposed to lack of efficacy.…”

Section: Discussionmentioning

confidence: 99%

“…There are several medical specialists that need to be involved in the management of these patients, which include neurologists, neurosurgeons, ophthalmologists, maxillo-facial surgeons, ENTs, psychiatrics, and physiotherapists. A multidisciplinary management from numerous specialists tends to make this topic of wide interest with a large audience of readers, including different medical and paramedical fields[ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Traumatic injuries, infectious diseases, metabolic disorders, and iatrogenic causes may determine different grades of FNP, requiring specific treatments according to the single case specifics[ 4 ]. In the short-to-midterm facial palsy, conservative management is usually preferred in cases of facial nerve anatomical preservation, while reconstructive techniques, such as nerve grafting, or flap harvesting are considered in patients showing facial nerve interruption or non-spontaneous restoration for longer than 6 mo[ 4 ]. The functional-aesthetic outcome, however, is often lower than expected after reconstructive surgeries.…”

Section: Introductionmentioning

confidence: 99%

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Role of stem cells-based in facial nerve reanimation: A meta-analysis of histological and neurophysiological outcomes

Ricciardi¹,

Pucci²,

Piazza³

et al. 2022

WJSC

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BACKGROUND Treatments involving stem cell (SC) usage represent novel and potentially interesting alternatives in facial nerve reanimation. Current literature includes the use of SC in animal model studies to promote graft survival by enhancing nerve fiber growth, spreading, myelinization, in addition to limiting fibrotic dege neration after surgery. However, the effectiveness of the clinical use of SC in facial nerve reanimation has not been clarified yet. AIM To investigate the histological, neurophysiological, and functional outcomes in facial reanimation using SC, compared to autograft. METHODS Our study is a systematic review of the literature, consistently conducted according to the preferred reporting items for systematic reviews and meta-analyses statement guidelines. The review question was: In facial nerve reanimation on rats, has the use of stem cells revealed as effective when compared to autograft, in terms of histological, neurophysiological, and functional outcomes? Random-effect meta-analysis was conducted on histological and neurophysiological data from the included comparative studies. RESULTS After screening 148 manuscript, five papers were included in our study. 43 subjects were included in the SC group, while 40 in the autograft group. The meta-analysis showed no significative differences between the two groups in terms of myelin thickness [CI: -0.10 (-0.20, 0.00); I 2 = 29%; P = 0.06], nerve fibers diameter [CI: 0.72 (-0.93, 3.36); I 2 = 72%; P = 0.6], compound muscle action potential amplitude [CI: 1.59 (0.59, 3.77); I 2 = 89%; P = 0.15] and latency [CI: 0.66 (-1.01, 2.32); I 2 = 67%; P = 0.44]. The mean axonal diameter was higher in the autograft group [CI: 0.94 (0.60, 1.27); I 2 = 0%; P ≤ 0.001]. CONCLUSION The role of stem cells in facial reanimation is still relatively poorly studied, in animal models, and available results should not discourage their use in future studies on human subjects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Role of stem cells-based in facial nerve reanimation: A meta-analysis of histological and neurophysiological outcomes

Ricciardi¹,

Pucci²,

Piazza³

et al. 2022

WJSC

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“…For all nerve injuries, time is "precious." 35 and immediate repair at the moment of the damage guarantees the best functional recovery. 12 Obviously, immediate action is not always possible, as in many studies the patients were referred to the surgeon by another provider.…”

Section: Timing Of Repairmentioning

confidence: 99%

Injuries of the Peripheral Mandibular Nerve, Evaluation of Interventions and Outcomes: A Systematic Review

Weyh

Pucci

Valentini

et al. 2021

Craniomaxillofacial Trauma & Reconstruction

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Trigeminal nerve injuries are common and there is currently no consensus on both timing and type of intervention to achieve the best outcomes. A systematic review was performed to compare the outcomes of the many different types of therapeutic interventions for nerve injury. PubMed, EBSCO, and Cochrane Review databases were used to search for studies published from January 1, 2000 to December 31, 2019. Included studies detailed treatment of an injury to peripheral branches of the trigeminal nerve, either known transection or injury causing persistent alteration in sensation. The primary outcome was functional sensory recovery via the Medical Research Council scale. Twenty studies were included, detailing outcomes of 608 subjects undergoing intervention for 622 nerve injuries. Surgical interventions were able to achieve functional sensory recovery in approximately >80% or more of the subjects. There was heterogeneity among how procedures were performed, timing to intervention, and methods of measuring recovery. The data of this study supports the ability of surgical intervention to achieve functional sensory recovery in a significant number of subjects, and found evidence for better outcomes with intervention closer to the time of injury.

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Advances in Facial Reanimation: Management of the Facial Nerve in the Setting of Vestibular Schwannoma

Funk

Greene

2021

Curr Otorhinolaryngol Rep

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Comparison between VII-to-VII and XII-to-VII coaptation techniques for early facial nerve reanimation after surgical intra-cranial injuries: a systematic review and pooled analysis of the functional outcomes

Cited by 10 publications

References 73 publications

Role of stem cells-based in facial nerve reanimation: A meta-analysis of histological and neurophysiological outcomes

Role of stem cells-based in facial nerve reanimation: A meta-analysis of histological and neurophysiological outcomes

Injuries of the Peripheral Mandibular Nerve, Evaluation of Interventions and Outcomes: A Systematic Review

Advances in Facial Reanimation: Management of the Facial Nerve in the Setting of Vestibular Schwannoma

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