Comparison between Ursodeoxycholic acid and Silymarin in Anticonvulsive drugs induced Hypertransaminasemia

Asgarshirazi, Masoumeh; Shariat, Mamak; Mousavi, Sabereh

doi:10.14800/ics.971

Cited by 2 publications

(1 citation statement)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Masoumeh Asgarshirazi et al prospectively studied the efficacy and tolerance of Silymarin and Ursodeoxycholic acid (UDCA) in 46 anticonvulsive drugs induced hypertransaminasemia. The results showed that after 1 month of Silymarin treatment, ALT changes were significantly better than those in UDCA group, without obvious side effects ( Masoumeh et al, 2015 ). A multicenter, retrospective, non-intervention cohort study conducted by Hong Zhao et al revealed that Silybin alone improved liver function in patients with DILI ( Zhao et al, 2021 ).…”

Section: Pharmacotherapy Strategiesmentioning

confidence: 98%

Pharmacotherapies for Drug-Induced Liver Injury: A Current Literature Review

et al. 2022

View full text Add to dashboard Cite

Drug-induced liver injury (DILI) has become a serious public health problem. For the management of DILI, discontinuation of suspicious drug or medicine is the first step, but the treatments including drugs and supporting approaches are needed. Reference to clinical patterns and disease severity grades of DILI, the treatment drugs were considered to summarize into hepatoprotective drugs (N-acetylcysteine and Glutathione, Glycyrrhizin acid preparation, Polyene phosphatidylcholine, Bicyclol, Silymarin), anticholestatic drug (Ursodeoxycholic acid, S-adenosylmethionine, Cholestyramine), immunosuppressants (Glucocorticoids) and specific treatment agents (L-carnitine, Anticoagulants). The current article reviewed the accumulated literature with evidence-based medicine researches for DILI in clinical practice. Also the drawbacks of the clinical studies involved in the article, unmet needs and prospective development for DILI therapy were discussed.

show abstract

Section: Pharmacotherapy Strategiesmentioning

confidence: 98%

Pharmacotherapies for Drug-Induced Liver Injury: A Current Literature Review

et al. 2022

View full text Add to dashboard Cite

show abstract

Exploring the protective effect of silymarin against flutamide-induced hepatotoxicity in male rats

2016

Res. Opin. Anim. Vet. Sci.

View full text Add to dashboard Cite

The current study was designed to explore the protective impact of silymarin (SIL) against the hepatotoxicity induced by daily treatment with flutamide (FLU), for one month, in intact male rats. Two different doses of FLU, one was low and corresponds to the human therapeutic dose (10 mg/kg) and the other was high and corresponds to ½ lowest lethal dose (500 mg/kg) were applied. Obtained results showed that oral administration of FLU in male rats significantly increased hepatic malonic dialdehyde (MDA), and markedly decreased hepatic reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-stranseferase (GST). In parallel, activities of alanine aminotranseferase (ALT), aspartate aminotranseferase (AST) and alkaline phosphatase (ALP), and level of total bilirubin in serum were significantly elevated; while serum total proteins, albumin and globulin, and hepatic total proteins were decreased in FLU-treated animals. Also, significant increases in serum and liver contents of total lipids (TL), total cholesterol (TC) and triglycerides (TG), and serum low density lipoproteins-cholesterol (LDL-c), which accompanied with decrease in serum level of high density lipoproteinscholesterol (HDL-c) following administration of FLU. The adverse effects of FLU on measured parameters appeared to be dose-dependent. Treatment with SIL (50 mg/kg) in rats given FLU (10 mg or 500 mg/kg) greatly improved the levels of investigated biomarkers of liver status. However, the beneficial effect of SIL was more remarkable in rats receiving FLU at a dose of 10 mg/kg. Obtained biochemical changes induced by the two used doses of FLU and the ameliorative impact of SIL were confirmed by histopathological examinations of liver sections of treated rats. In conclusion, SIL can be used effectively in the protection against hepatotoxicity induced by FLU.

show abstract

Comparison between Ursodeoxycholic acid and Silymarin in Anticonvulsive drugs induced Hypertransaminasemia

Cited by 2 publications

References 27 publications

Pharmacotherapies for Drug-Induced Liver Injury: A Current Literature Review

Pharmacotherapies for Drug-Induced Liver Injury: A Current Literature Review

Exploring the protective effect of silymarin against flutamide-induced hepatotoxicity in male rats

Contact Info

Product

Resources

About