Comparison Between Treacher Collins Syndrome and Pierre Robin Sequence: A Cephalometric Study

Kato, Renata Mayumi; Moura, Priscila Padilha; Zechi-Ceide, Roseli Maria; Tonello, Cristiano; Peixoto, Adriano Porto; Garib, Daniela Gamba

doi:10.1177/1055665620937499

Cited by 6 publications

(3 citation statements)

References 42 publications

(84 reference statements)

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“…The design of scientific studies on patients affected by clefts should separately analyze groups of patients with clefts involving the lip and palate from those with the palate involved only. Nevertheless, many studies can be found comparing patients with various types of clefts, without non-cleft control groups of the same ethnicity [ 3 , 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of Primary Palatal Surgery on Craniofacial Morphology in Patients with Cleft Palate Only (CPO)—Systematic Review with Meta-Analysis

Janiszewska‐Olszowska

Grocholewicz

Mazur

et al. 2022

IJERPH

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Background: Cleft palate only (CPO) is the second most prevalent cleft type. Both the cleft and palatal scarring may affect craniofacial growth. The aim of this systematic review was to summarize scientific evidence on effect of palatal surgery on craniofacial morphology in CPO. Methods: A search was conducted in PubMed, PMC, WoS, Scopus, Embase, using the keywords: “cleft palate” AND (“craniofacial morphology” OR “cephalometric analysis”) NOT “lip” with inclusion and exclusion criteria ensuring confident, direct comparison between study groups. The quality assessment was performed with Arrive’s scale for radiologic examinations. Results: Of 713 potential articles, 19 were subjected to qualitative analysis and 17 to meta-analysis, which confirmed reduced SNA in unoperated CPO versus non-cleft individuals. No scientific evidence was found directly assessing the effect of surgery on craniofacial morphology. The negative effect of palatal surgery was seen indirectly: in treated CPO versus non-cleft, the size effect of SNA is bigger than in untreated CPO versus non-cleft. A high heterogeneity came from a few non-European publications. Conclusions: CPO is associated with sagittal maxillary deficiency resulting both from the cleft and from primary surgery, disregarding cleft severity in operated CPO patients. Ethnic differences influence craniofacial morphology in CPO. This research received no external funding. Study protocol number in PROSPERO database: CRD42021268957.

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Section: Introductionmentioning

confidence: 99%

Influence of Primary Palatal Surgery on Craniofacial Morphology in Patients with Cleft Palate Only (CPO)—Systematic Review with Meta-Analysis

Janiszewska‐Olszowska

Grocholewicz

Mazur

et al. 2022

IJERPH

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“…Existing data that describe the craniofacial parameters of TCS patients have been collected using direct anthropometric measurements, cephalometric measurements, and computed tomography (CT)-based measurements. 8,10,11 Most data have been collected and applied to pediatric populations, [11][12][13][14] but minimal data regarding the adult population have been reported. The use of a CT-based three-dimensional analysis technique is now considered the main technique for diagnosing TCS, assessing patients throughout follow-up, and planning for reconstructive surgery.…”

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confidence: 99%

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confidence: 99%

Craniofacial and Upper Airway Development in Patients With Treacher Collins Syndrome

Lin

Ma²,

Huang³

et al. 2021

Journal of Craniofacial Surgery

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This study evaluated age-associated morphology changes in the cranial base, facial development, and upper airway of patients with Treacher Collins syndrome (TCS). A total of 33 preoperative computed tomographic images (TCS, n ¼ 14; control, n ¼ 19) were included in the study and divided into three age-related subgroups (2-6 years, 7-18 years, and older than 18 years). Linear, angular cephalometric measurements and upper airway volumes were collected. All measurements were analyzed using ProPlan CMF software (version 3.0; Materialize, Leuven, Belgium). The association between aging and upper airway morphology was analyzed. Compared to control subjects, TCS patients had a smaller cranial base, maxilla, and nose; they also had reduced upper airway volume compared to control subjects. The observed differences were most significant in patients between the ages of 7 and 18 years. This study used computed tomography-based three-dimensional analyses to provide a detailed description of age-related changes that occur in craniofacial measurements and upper airway volumes in children, adolescents, and young adult patients with TCS in China. These data can be used to evaluate individual patients with TCS and to select treatment to improve the growth of the craniofacial region.

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Mandibular Dysmorphology and Clinical Presentation in Treacher Collins Syndrome

Tonello,

Dias,

Nunes

et al. 2023

The Cleft Palate Craniofacial Journal

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Introduction Treacher Collins syndrome is a rare congenital disease characterized by the multiple craniofacial malformations. Although the deformities affecting patients with Treacher Collins syndrome have been well characterized, the effects of these malformations to clinical severity of the syndrome are not well understood. Objective To determine the association of specific Treacher Collins mandibular malformations with clinical severity. Design A retrospective radiographic observational study. Setting Study conducted at a single institution, a quaternary craniofacial care center Patients 54 patients with Treacher Collins syndrome. Interventions Computed tomography (CT), clinical photographs and medical history were included in this analysis. Mandibles were isolated from CT data and reconstructed in three dimensions using Mimics software. Cephalometric measurements were performed on CT data. Clinical severity was determined by Teber and Vincent scores. Association of craniofacial dysmorphology to clinical severity was determined by Spearman rank coefficient. Main outcome measures The main results obtained were the measurements of the mandibles and the quantification of the malformations of the evaluated patients Results Among the most frequent findings in the sample are hypoplasia of the zygomatic complex, descending palpebral cleft and mandibular hypoplasia. Patients with a lower ramus/corpus ratio had a higher (more severe) Teber and Vincent classification. Conclusion Patients with the most compromised mandible are also the patients with the highest number of malformations, thus, the most severe patients.

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Comparison Between Treacher Collins Syndrome and Pierre Robin Sequence: A Cephalometric Study

Cited by 6 publications

References 42 publications

Influence of Primary Palatal Surgery on Craniofacial Morphology in Patients with Cleft Palate Only (CPO)—Systematic Review with Meta-Analysis

Influence of Primary Palatal Surgery on Craniofacial Morphology in Patients with Cleft Palate Only (CPO)—Systematic Review with Meta-Analysis

Craniofacial and Upper Airway Development in Patients With Treacher Collins Syndrome

Mandibular Dysmorphology and Clinical Presentation in Treacher Collins Syndrome

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