Comparison between transvaginal sonography, saline contrast sonovaginography and magnetic resonance imaging in the diagnosis of posterior deep infiltrating endometriosis

Saccardi, Carlo; Cosmi, Erich; Borghero, Angela; Tregnaghi, Alberto; Dessole, Salvatore; Litta, Pietro

doi:10.1002/uog.11102

Cited by 80 publications

(116 citation statements)

References 31 publications

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“…An important analysis carried out by this study is the search for a cutoff specifically for peritoneal endometriosis since we excluded patients with deep and ovarian endometriosis because we know that a proper transvaginal ultrasonography has great sensitivity for the diagnosis of deep and ovarian endometriosis [29,31,32,36]. In our analysis, we had an increase in the sensitivity of the method with little loss of specificity with high NPV (97%), suggesting that the cutoff for endometriosis is not the same as that for hyperprolactinemia or ovarian tumors.…”

Section: Discussionmentioning

confidence: 99%

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Serum Prolactin and CA-125 Levels as Biomarkers of Peritoneal Endometriosis

Bilibio

Souza

Rodini

et al. 2014

Gynecol Obstet Invest

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Background/Aims: To evaluate serum prolactin and CA-125 levels as biomarkers for the diagnosis of peritoneal endometriosis. Methods: A prospective study was performed. Blood samples were drawn from a peripheral vein during the secretory phase of the menstrual cycle (day 19-21 prior to the surgery) to analyze through relative operating characteristic curve the serum prolactin and CA-125 levels for diagnosis of peritoneal endometriosis. The study wasperformed with 97 participants, 63 women with peritoneal endometriosis and 34 healthy women. Results: The sensitivity and specificity of peritoneal endometriosis diagnosis were equivalent for prolactin (21 and 99%) and for CA-125 (27 and 97%; p = 0.58). These two markers were used in a parallel test utilizing the usual cutoff (prolactin 20.0 ng/ml and CA-125 35 U/I). The sensitivity and specificity were 44 and 99%. However, by utilizing the best cutoff (prolactin 14.8 ng/ml and for CA-125 19.8 U/I), sensitivity, specificity and negative predictive value were 77, 88 and 97%, respectively. Conclusion: Serum CA-125 and prolactin levels assessed together, and considering the cutoff for CA-125 (19.9 U/I) and prolactin (14.8 ng/ml), allow the diagnosis of peritoneal endometriosis with acceptable sensitivity and specificity (77 and 88%) and a high negative predictive value (97%).

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Section: Discussionmentioning

confidence: 99%

“…We did not include patients with endometrioma or deep endometriosis. In both cases, an adequate transvaginal ultrasonography and physical examination showed an adequate sensitivity to diagnose endometriosis [28,29,30,31,32]. …”

Section: Methodsmentioning

confidence: 99%

Serum Prolactin and CA-125 Levels as Biomarkers of Peritoneal Endometriosis

Bilibio

Souza

Rodini

et al. 2014

Gynecol Obstet Invest

View full text Add to dashboard Cite

show abstract

“…Encouragingly, in their recent saline contrast sonovaginography study, Saccardi et al 2 were able to obtain sensitivities of 95% and 81% for the prediction of DIE in the vaginal fornix and RVS, respectively. Interestingly, however, the same study could predict bowel endometriosis with a sensitivity of only 67%.…”

Section: Reply: New Ultrasound Technologies To Classify Deep Pelvic Ementioning

confidence: 99%

Reply: New ultrasound technologies to classify deep pelvic endometriosis

Reid

Lü

Hardy

et al. 2015

Ultrasound in Obstet & Gyne

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“…Endometriosis is defined as the presence of ectopic deposits of viable endometrial tissue outside of the uterus usually limited to anatomical sites within the pelvis, but not exclusively [3,4].…”

Section: Introductionmentioning

confidence: 99%

Could surgeon’s expertise resolve the debate about surgery effectiveness in treatment of endometriosis-related infertility?

Gizzo

Conte

Gangi

et al. 2014

Arch Gynecol Obstet

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In patients affected by endometriosis, the choice between expectant management versus intervention should be personalized: when the estimated probability of natural conception is low, surgery may be considered as a second-line treatment. Conversely, in all other cases surgery should be offered early (as a first-line approach) as it improves the chance of spontaneous conception. The laparoscopic treatment of infertility due to endometriosis must be performed by a skilled specialized surgeon to ensure a complete "pelvic cleanout" while respecting the anatomical structures and reducing the risk of fertility impairment due to surgical procedures.

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Comparison between transvaginal sonography, saline contrast sonovaginography and magnetic resonance imaging in the diagnosis of posterior deep infiltrating endometriosis

Abstract: Objective To compare clinical evaluation, transvaginal sonography (TVS), saline contrast sonovaginography (SCSV) and magnetic resonance imaging (MRI) in the diagnosis of posterior deep pelvic endometriosis (DPE). Methods

Cited by 80 publications

References 31 publications

Serum Prolactin and CA-125 Levels as Biomarkers of Peritoneal Endometriosis

Serum Prolactin and CA-125 Levels as Biomarkers of Peritoneal Endometriosis

Reply: New ultrasound technologies to classify deep pelvic endometriosis

Could surgeon’s expertise resolve the debate about surgery effectiveness in treatment of endometriosis-related infertility?

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