Comparison between Transdermal Buprenorphine and Transdermal Fentanyl for Postoperative Pain Relief after Major Abdominal Surgeries

Arshad, Zia; Prakash, Ravi; Kumar, Sanjeev

doi:10.7860/jcdr/2015/16327.6917

Cited by 22 publications

(29 citation statements)

References 13 publications

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“…Some authors argued that TFP could prevent acute opioid tolerance and hyperalgesia in the early postoperative period (14). Many studies have identified that TFP has a positive role in reducing pain intensity in patients undergoing abdominal hysterectomy (15), abdominal surgery (16) and osteoarthritis patients (17).…”

Section: Discussionmentioning

confidence: 99%

Transdermal fentanyl patch provides better pain relief and faster functional recovery after total knee arthroplasty:a meta-analysis

Wu¹,

Li²,

Liu³

et al. 2020

Preprint

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Background : Pain after total knee arthroplasty (TKA) was severe and should be effectively managed. This meta-analysis aimed to compare transdermal fentanyl patch (TFP) versus placebo for pain control after TKA. Methods : PubMed, Embase, Cochrane library and Chinese National Knowledge Infrastructure (CNKI) were electronically searched. Potential clinical studies that investigated the effect and safety of TFP versus control in TKA patients were searched. The primary outcomes were total morphine consumption. Stata 12.0 was used for meta-analysis. Results : Four randomized controlled trials (RCTs) involving 110 TKA patients were included in this meta-analysis. Compared with control group, TFP was associated with a reduction of total morphine consumption (WMD: -16.14; 95% CI: -25.82 to -6.46; P=0.001). Moreover, TFP could significantly reduce VAS at 2 h, 4 h, 6 h, 12 h, 24 h, 48 h and 72 h (P<0.05). There was no statistically significance between the nausea, vomiting, hypertension, sweating, respiratory depression, pruritus and urine retention (P>0.05). Conclusion : The present meta-analysis showed that use of TFP for the management of moderate or severe TKA postoperative pain had more advantages compared to placebo. Further large-scale, prospective RCTs are required to verify the effect of TFP and optimal dose of TFP in TKA patients.

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Section: Discussionmentioning

confidence: 99%

Transdermal fentanyl patch provides better pain relief and faster functional recovery after total knee arthroplasty:a meta-analysis

Wu¹,

Li²,

Liu³

et al. 2020

Preprint

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“…[18] We could not find any study comparing the use of TDB to oral analgesics in the management of post-operative pain.…”

Section: Discussionmentioning

confidence: 99%

Safety and efficacy of transdermal buprenorphine versus oral tramadol for the treatment of post-operative pain following surgery for fracture neck of femur: A prospective, randomised clinical study

et al. 2017

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“…To our knowledge, there are no clinical trials of buccal buprenorphine film for acute pain, but transdermal buprenorphine has proven efficacy in the treatment of postsurgical acute pain. [71][72][73][74][75][76] Future studies may provide more information regarding additional uses for buprenorphine in pain management; however, these formulations are not currently FDA approved for acute pain treatment.…”

Section: The Clinical Efficacy Of Buprenorphine In Chronic Painmentioning

confidence: 99%

<p>Safety And Efficacy Of The Unique Opioid Buprenorphine For The Treatment Of Chronic Pain</p>

Pergolizzi¹,

Raffa²

2019

JPR

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Background: Chronic pain is associated with decreased quality of life and is one of the most common reasons adults seek medical care, making treatment imperative for many aspects of patient well-being. Chronic pain management typically involves the use of Schedule II full μ-opioid receptor agonists for pain relief; however, the increasing prevalence of opioid addiction is a national crisis that is impacting public health and social and economic welfare. Buprenorphine is a Schedule III partial μ-opioid receptor agonist that is an equally effective but potentially safer treatment option for chronic pain than full μ-opioid receptor agonists. The purpose of this review is to provide an overview of the clinical efficacy and safety of the transdermal and buccal formulations of buprenorphine, which are approved by the Food and Drug Administration for chronic pain, compared with that of extended-release full μ-opioid receptor agonists. Methods: Controlled or randomized controlled clinical trial information was retrieved from EMBASE, Medline, and PubMed using the search terms "buprenorphine" AND "chronic" AND "pain." Results: A total of 33 clinical studies were ultimately used in this review, including 29 (88%) on transdermal buprenorphine and 4 (12%) on buprenorphine buccal film. Although the measure of pain intensity varied among studies, each of these 33 trials demonstrated efficacy for buprenorphine in pain relief. A total of 28 studies also assessed safety, with each concluding that buprenorphine was generally well tolerated. Conclusion: Comparison of current clinical data along with results of responder and safety analyses support the use of buprenorphine over full μ-opioid receptor agonists for effective preferential treatment of chronic pain; however, head-to-head clinical studies are warranted.

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Comparison between Transdermal Buprenorphine and Transdermal Fentanyl for Postoperative Pain Relief after Major Abdominal Surgeries

Cited by 22 publications

References 13 publications

Transdermal fentanyl patch provides better pain relief and faster functional recovery after total knee arthroplasty:a meta-analysis

Transdermal fentanyl patch provides better pain relief and faster functional recovery after total knee arthroplasty:a meta-analysis

Safety and efficacy of transdermal buprenorphine versus oral tramadol for the treatment of post-operative pain following surgery for fracture neck of femur: A prospective, randomised clinical study

<p>Safety And Efficacy Of The Unique Opioid Buprenorphine For The Treatment Of Chronic Pain</p>

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