Comparison between tidal breathing and dosimeter methods in assessing cough receptor sensitivity to capsaicin

Songur, Nejla; Fujimura, Masaki; Kamio, Yumie

doi:10.1111/j.1440-1843.2000.00273.x

Cited by 19 publications

(11 citation statements)

References 22 publications

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“…The control group consisted of 21 subjectively healthy non-smoking subjects (12 women and 9 men) aged between 25 and 54 years, with a median age of 41 years (95% CI: [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49]. They were screened using questions on airway symptoms and symptoms in response to chemicals and scents.…”

Section: Study Participantsmentioning

confidence: 99%

See 1 more Smart Citation

Sensitivity to Environmental Irritants and Capsaicin Cough Reaction in Patients with a Positive Methacholine Provocation Test before and after Treatment with Inhaled Corticosteroids

Ekstrand¹,

Ternesten-Hasséus²,

Arvidsson³

et al. 2011

Journal of Asthma

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show abstract

Section: Study Participantsmentioning

confidence: 99%

“…This prospective study included 18 consecutively chosen patients, 9 women and 9 men, aged between 18 and 60 years, with a median age of 35 years (95% confidence interval [CI]: [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44].…”

Section: Study Participantsmentioning

confidence: 99%

Sensitivity to Environmental Irritants and Capsaicin Cough Reaction in Patients with a Positive Methacholine Provocation Test before and after Treatment with Inhaled Corticosteroids

Ekstrand¹,

Ternesten-Hasséus²,

Arvidsson³

et al. 2011

Journal of Asthma

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show abstract

“…This would be of particular concern during the administration of concentrations that induce significant coughing, thereby preventing the subject from inhaling the tussive agent for a significant portion of the fixed time period of aerosol delivery. Nevertheless, a recently published comparison of the tidal breathing and dosimeter methods of capsaicin inhalation challenge demonstrated both to be reproducible, with good agreement between the two methods [26].…”

Section: Administration Of Capsaicin and Citric Acidmentioning

confidence: 99%

“…Indeed, continual inhalation over 1 min of citric acid or capsaicin results in a reduction in cough frequency of a third with capsaicin and complete abrogation with citric acid. employing the dose-response method and the single dose, with both the single-breath technique [11,16,17,26,29,33,[36][37][38][39][40][41] and a fixed time period of capsaicin and citric acid inhalation [15-18, 26, 35, 42, 43].…”

Section: Tachyphylaxis and Reproducibilitymentioning

confidence: 99%

ERS guidelines on the assessment of cough

Morice¹,

Fontana²,

Belvisi³

et al. 2007

Eur Respir J

603

619

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“…Present findings in the literature suggest that cough reflex sensitivity in NAEB contributes to cough and eosinophilic inflammation is associated with increased cough reflex sensitivity. The severity of coughing, increased cough reflex sensitivity (C5 <3.9 mM) and sputum eosinophil ratio are reduced by inhaled and/or oral corticosteroid therapy [34,36]. However; in another study which was conducted by Park et al [37] and in which long-term follow-ups of the patients were made, the recurrence of sputum eosinophilia (3%) in the asymptomatic period in a group of patients suggested that chronic cough in NAEB patients was not always associated with eosinophilic inflammation.…”

Section: Clinical Featuresmentioning

confidence: 99%

Non-astmatic Eosinophilic Bronchitis

Yıldız

Dülger

2018

Turk Thorac J

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Non-asthmatic eosinophilic bronchitis (NAEB) is a chronic disease and was first described in a small group of patients by Gibson et al. [1,2] in a relatively recent date. Without bronchospasm, it is defined as eosinophilic inflammation of the respiratory tract and is usually associated with eosinophilia in sputum. It is one of the most important causes of chronic cough [3].When a cough lasting longer than 8 weeks is detected in clinical practice; if chest X-ray is normal, this situation is defined as chronic cough. Chronic cough is a common cause of complaints all over the world, especially at the centers giving outpatient care, and is responsible for about 40% of the applications [4][5][6]. However, the cause(s) leading to this condition can be detected in 75-90% [7][8][9]. NAEB is a disease that should be remembered in the differential diagnosis of chronic cough but it is often ignored [10]. Because the systematic examination of bronchial inflammation can be made rarely, it is probably diagnosed less than it exists [11]. When the other causes that may lead to chronic cough are eliminated in patients applying with the complaint of chronic cough, NAEB should be taken into consideration [12][13][14][15][16][17][18][19].The purpose of this article is to make it possible to consider the differential diagnosis of patients with chronic cough by drawing attention to NAEB, and to compile and present the literature data that is relatively limited. ETIOLOGYAlthough the etiology of NAEB is not clear yet, environmental or occupational factors may be responsible for this situation in some of the patients. In a significant proportion of the diagnosed patients, occupational dust exposure was considered to be possibly etiologically responsible. For this reason, the possibility of occupation-related causes should be considered in patients with chronic cough due to NAEB [20]. Especially resin hardener, welding fume and formaldehyde exposures have been shown to lead to NAEB [21][22][23][24]. Non-asthmatic eosinophilic bronchitis (NAEB) is eosinophilic inflammation of the respiratory tract, without any bronchospasm. In this article, we want to draw attention to the NAEB. It should also be considered in differential diagnosis of chronic cough. Eosinophilia is present in all induced or spontaneous sputum samples of NAEB patients. NAEB patients and asthmatic patients have similar airway inflammation. Remarkably, NAEB mainly occurs in the lower airways. Unlike asthma, mast cells in NAEB are active in the bronchial epithelium. Diagnosis is based on the clinical, radiological, and spirometric measurements of other causes of chronic cough (Post-nasal discharge syndrome, asthma, gastroesophageal reflux etc.) and the assessment of inflammation in the lower respiratory tract. Airway inflammation can be assessed by sputum induction. The main treatment is anti-inflammatory therapy with inhaled corticosteroids and taking protective measures if inflammation is due to occupational exposure or allergen inhalation. If NAEB is untreated, it may be ...

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Comparison between tidal breathing and dosimeter methods in assessing cough receptor sensitivity to capsaicin

Abstract: Although the agreement between the two methods was considered to be good, higher concentrations of capsaicin solution were required to determine the cough threshold in the dosimeter method, resulting in an unpleasant sensation in the throat.

Cited by 19 publications

References 22 publications

Sensitivity to Environmental Irritants and Capsaicin Cough Reaction in Patients with a Positive Methacholine Provocation Test before and after Treatment with Inhaled Corticosteroids

Sensitivity to Environmental Irritants and Capsaicin Cough Reaction in Patients with a Positive Methacholine Provocation Test before and after Treatment with Inhaled Corticosteroids

ERS guidelines on the assessment of cough

Non-astmatic Eosinophilic Bronchitis

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