Comparison between the STENTYS self-apposing bare metal and paclitaxel-eluting coronary stents for the treatment of saphenous vein grafts (ADEPT trial)

Abstract

AimsTo describe the safety and performance of STENTYS self-expandable bare metal stents (BMS) versus paclitaxel-eluting stents (PES) in saphenous vein grafts (SVGs).Methods and ResultsA randomised controlled trial was performed in four hospitals in three European countries between December 2011 and December 2013. Patients with de novo lesions (>50% stenosis) in an SVG with a diameter between 2.5–6 mm were included. Primary endpoint was late lumen loss at 6 months. Secondary endpoints included procedural success and the occurrence of major adverse cardiac events (MACE) at 12 months. A total of 57 patients were randomised to STENTYS self-apposing BMS (n = 27) or PES (n = 30). Procedural success was obtained in 89.5%. No significant differences in late lumen loss were found between BMS and PES at 6 months (0.53 mm vs 0.47; p = 0.86). MACE rates at 12 months were comparable in both groups (BMS 22.2% vs. PES 26.7%; p = 0.70).ConclusionsTreatment of SVGs with STENTYS self-expandable stents is safe and effective. No significant differences were found in late lumen loss and MACE between BMS and PES.

Smart materials in cardiovascular implants: Shape memory alloys and shape memory polymers

“…38 No difference was observed between the two different types of stents, however, the STENTYS self-expanding stent was noted to be safe and effective. 38 In contrast, the sirolimus eluting SPARROW stent has been shown to significantly decrease late lumen loss in small coronary arteries when compared to the bare metal SPARROW stent at 8 months indicating a potential for a lower rate of restenosis. 39 4.1.2 | Shape memory polymer stents Current polymeric stents, Igaki-Tamai and DESolve, still require deployment with the addition of balloon expansion although their shape memory effect does afford them some self-expanding capabilities.…”

Five-year clinical follow-up of the STENTYS self-apposing stent in complex coronary anatomy: a single-centre experience with report of specific angiographic indications

“…The stent is available as bare-metal stent and drug-eluting stent (paclitaxel or sirolimus). Since apposition is possible in large and variable vessel diameters of, for example, proximal and distal main branches, the stent can be used safely and effectively in bifurcation lesions [ 7 – 9 ] and in saphenous vein grafts [ 10 ]. Moreover, the nitinol platform can enlarge further after implantation.…”

Analysis of Varicose Veins of Lower Extremities Based on Vascular Endothelial Cell Inflammation Images and Multi-Scale Deep Learning

“…Hypoxia, venous hypertension, and decreased sheer force of blood flow are important factors leading to the initiation of varicose venous inflammatory response. The study of Ijsselmuiden et al [28] found that perfusion of hypoxic solution into the vein can cause adhesion reaction between neutrophils and endothelial cells, suggesting that a certain degree of decrease in blood oxygen partial pressure, such as during blood stasis, can cause activation of vascular endothelial cells. Moreover, the enhanced adhesion reaction between neutrophils and endothelial cells promoted the production of reactive oxide species (ROS) caused the release of multiple cytokines, leukotriene B4, and other inflammatory mediators.…”