Comparison between the behavioural effects of septal and hippocampal lesions: A review

Gray, Jeffrey A.; McNaughton, Neil

doi:10.1016/0149-7634(83)90014-3

Cited by 660 publications

(291 citation statements)

References 610 publications

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“…This is in contrast to the GluRA Ϫ/Ϫ mice in which the rewarded-alternation deficit is both profound and lasting, with knock-out mice displaying chance levels of performance even after repeated test sessions (Reisel et al, 2002). In this respect, GluRA Ϫ/Ϫ mice resemble rodents with lesions to the septohippocampal system (Rawlins and Olton, 1982;Gray and McNaughton, 1983), although it should also be noted that impaired synaptic plasticity at any one of several sets of synapses within the septohippocampal system could underlie a spatial WM impairment. Tissue-specific GluRA knock-outs, in which the gene deletion can be limited to just the hippocampus or possibly even to specific subfields within the hippocampus, should resolve this issue.…”

Section: Discussionmentioning

confidence: 80%

A Within-Subjects, Within-Task Demonstration of Intact Spatial Reference Memory and Impaired Spatial Working Memory in Glutamate Receptor-A-Deficient Mice

et al. 2003

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Gene-targeted mice lacking the AMPA receptor subunit glutamate receptor-A (GluRA) (GluR1) and wild-type controls were compared on a radial-maze task in which the same three of six arms were always baited, but in which the rewards of milk were not replaced within a trial. This procedure allowed not only a within-subjects but also a within-trials assessment of both spatial working memory (WM) and reference memory (RM) in GluRA Ϫ/Ϫ mice, using identical spatial cues. In experiment 1, the GluRA Ϫ/Ϫ mice made more WM and RM errors during task acquisition. However, separate groups of GluRA Ϫ/Ϫ and wild-type mice (experiment 2) acquired a purely RM version of the task at a similar rate, using a paradigm with which it was not possible to make WM errors (doors prevented mice from re-entering an arm that they had already visited on that trial). In contrast, mice with hippocampal lesions were dramatically impaired. These results are consistent with the possibility that the WM impairment in the GluRA Ϫ/Ϫ mice during experiment 1 produced interference that disrupted RM acquisition. A WM component was therefore introduced after RM acquisition in experiment 2 (i.e., the mice were no longer prevented from re-entering a previously visited arm). The GluRA Ϫ/Ϫ mice now made considerably more WM errors than did wild-type mice, but simultaneously, RM was only mildly and transiently impaired. These experiments provide additional evidence of a selective spatial WM deficit coexisting with intact spatial RM acquisition in GluRA Ϫ/Ϫ mice, suggesting that different neuronal mechanisms within the hippocampus may support these different kinds of information processing.

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Section: Discussionmentioning

confidence: 80%

A Within-Subjects, Within-Task Demonstration of Intact Spatial Reference Memory and Impaired Spatial Working Memory in Glutamate Receptor-A-Deficient Mice

et al. 2003

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“…The reason for this is not clear, but it should be noted that they also did not find any effect of the septum lesion in this task. Earlier studies in which rats with lesions of the septohippocampal system were tested in the passive avoidance test yielded contrasting results [20]. The precise setting and conditions under which these tests are carried out seem to be critical for the results.…”

Section: Discussionmentioning

confidence: 99%

Effects of an electrolytic lesion of the prelimbic area on anxiety-related and cognitive tasks in the rat

Maaswinkel

Gispen

Spruijt

1996

Behavioural Brain Research

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The aim of this paper was to study the role of the prelimbic area of rats in response selection• A bilateral electrolytic lesion was made in the prelimbic area. The rats were tested in the Morris water-maze, the conditioned shock-prod burying test, the elevated plus-maze, a modified open field test, and the step-through passive avoidance test. In the water-maze during initial acquisition, the latency times of the lesioned rats were not different from those of the controls, but they found the platform faster than the shamoperated rats after the platform was placed in a new position. The lesion did not affect performance in the shock-prod burying test. In the elevated plus-maze the lesioned rats were more active than the sham-operated rats and spent more time on the open arms. In the open field there was no difference between lesioned and sham-operated rats with regard to distance travelled or the time spent near the object in the center of the open field. In the passive avoidance test the lesioned rats had a shorter latency time to enter the shock compartment during the retention trial than the sham-operated rats did. The results were discussed in relation to those of similar studies. The extent and precise localisation of the lesion seems to be crucial for the outcome: lesions confined to the prelimbic area may have the opposite effects of larger lesions. Furthermore, it may well be that the prelimbic area is only involved in processing of stimuli of a specific sensory modality, as made probable by the results of different conditioned reinforcement tasks. Finally, it was stated that we still lack a hypothesis about the precise role of the prelimbic area in response selections.

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“…The hippocampus has the highest concentration of GC receptors (McEwen et al, 1986), and chronic HPA axis activation and GC hypersecretion are associated with disturbances in hippocampal morphology (Davis et al, 1986;Woolley et al, 1990;Watanabe et al, 1992;Magariños and McEwen, 1995;Sapolsky, 1996;Lupien and McEwen, 1997;Lupien et al, 1998;Porter and Landfield, 1998) and function (McEwen and Sapolsky, 1995). In rodents, normal hippocampal function is required for adequate exploratory behavior in a novel environment and for spatial recognition memory (Britton et al, 1982;Gray, 1982;Sutton et al, 1982;Gray and McNaughton, 1983;Koob and Bloom, 1985;Liang and Lee, 1988).…”

Section: Abstract: Apoe; Pituitary; Adrenal Gland; Acth; Corticostermentioning

confidence: 99%

Hypothalamic–Pituitary–Adrenal Dysfunction inApoe^−/−Mice: Possible Role in Behavioral and Metabolic Alterations

et al. 2000

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Several neurological diseases are frequently accompanied by dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. The HPA axis regulates the secretion of glucocorticoids (GCs), which play important roles in diverse brain functions, including cognition, emotion, and feeding. Under physiological conditions, GCs are adaptive and beneficial; however, prolonged elevations in GC levels may contribute to neurodegeneration and brain dysfunction. In the current study, we demonstrate that apolipoprotein E (apoE) deficiency results in agedependent dysregulation of the HPA axis through a mechanism affecting primarily the adrenal gland. Apoe Ϫ/Ϫ mice, which develop neurodegenerative alterations as they age, had an age-dependent increase in basal adrenal corticosterone content and abnormally increased plasma corticosterone levels after restraint stress, whereas their plasma and pituitary adrenocorticotropin levels were either unchanged or lower than those in controls. HPA axis dysregulation was associated with behavioral and metabolic alterations. When anxiety levels were assessed in the elevated plus maze, Apoe Ϫ/Ϫ mice showed more anxiety than wild-type controls. Apoe Ϫ/Ϫ mice also showed reduced activity in the open field. Finally, Apoe Ϫ/Ϫ mice showed age-dependent increases in food and water intake, stomach and body weights, and decreases in brown and white adipose tissues. These results support a key role for apoE in the tonic inhibition of steroidogenesis and HPA axis activity and have important implications for the behavioral analysis of Apoe Ϫ/Ϫ mice.

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Comparison between the behavioural effects of septal and hippocampal lesions: A review

Cited by 660 publications

References 610 publications

A Within-Subjects, Within-Task Demonstration of Intact Spatial Reference Memory and Impaired Spatial Working Memory in Glutamate Receptor-A-Deficient Mice

A Within-Subjects, Within-Task Demonstration of Intact Spatial Reference Memory and Impaired Spatial Working Memory in Glutamate Receptor-A-Deficient Mice

Effects of an electrolytic lesion of the prelimbic area on anxiety-related and cognitive tasks in the rat

Hypothalamic–Pituitary–Adrenal Dysfunction inApoe^−/−Mice: Possible Role in Behavioral and Metabolic Alterations

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Comparison between the behavioural effects of septal and hippocampal lesions: A review

Cited by 660 publications

References 610 publications

A Within-Subjects, Within-Task Demonstration of Intact Spatial Reference Memory and Impaired Spatial Working Memory in Glutamate Receptor-A-Deficient Mice

A Within-Subjects, Within-Task Demonstration of Intact Spatial Reference Memory and Impaired Spatial Working Memory in Glutamate Receptor-A-Deficient Mice

Effects of an electrolytic lesion of the prelimbic area on anxiety-related and cognitive tasks in the rat

Hypothalamic–Pituitary–Adrenal Dysfunction inApoe−/−Mice: Possible Role in Behavioral and Metabolic Alterations

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Product

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Hypothalamic–Pituitary–Adrenal Dysfunction inApoe^−/−Mice: Possible Role in Behavioral and Metabolic Alterations