Comparison between tagged MRI and standard cine MRI for evaluation of left ventricular ejection fraction

Dornier, Christophe; Somsen, G. Aernout; Ivancevic, Marko K.; Osman, Nael F.; Didier, Dominique; Righetti, A; Vallée, Jean‐Paul

doi:10.1007/s00330-004-2311-7

Cited by 19 publications

(12 citation statements)

References 16 publications

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“…However, even if these results depicted the contraction deficit relative to infarction, an important improvement in function evaluation would be to perform assessment of intramyocardial strains, either by displacement-encoded imaging with stimulated echos (DENSE) (34) or with myocardial tagging, as was previously reported in rat myocardium (35) and also in mice (36,37). Moreover, it has been shown that myocardial tagging can also provide accurate EF measurement (38), so both regional and global function can be acquired in one single acquisition.…”

Section: Function Assessmentmentioning

confidence: 94%

Myocardial infarction quantification with Manganese‐Enhanced MRI (MEMRI) in mice using a 3T clinical scanner

et al. 2010

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Manganese (Mn(2+)) was recognized early as an efficient intracellular MR contrast agent to assess cardiomyocyte viability. It had previously been used for the assessment of myocardial infarction in various animal models from pig to mouse. However, whether Manganese-Enhanced MRI (MEMRI) is also able to assess infarction in the acute phase of a coronary occlusion reperfusion model in mice has not yet been demonstrated. This model is of particular interest as it is closer to the situation encountered in the clinical setting. This study aimed to measure infarction volume taking TTC staining as a gold standard, as well as global and regional function before and after Mn(2+) injection using a clinical 3T scanner. The first step of this study was to perform a dose-response curve in order to optimize the injection protocol. Infarction volume measured with MEMRI was strongly correlated to TTC staining. Ejection fraction (EF) and percent wall thickening measurements allowed evaluation of global and regional function. While EF must be measured before Mn(2+) injection to avoid bias introduced by the reduction of contrast in cine images, percent wall thickening can be measured either before or after Mn(2+) injection and depicts accurately infarct related contraction deficit. This study is the first step for further longitudinal studies of cardiac disease in mice on a clinical 3T scanner, a widely available platform.

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Section: Function Assessmentmentioning

confidence: 94%

Myocardial infarction quantification with Manganese‐Enhanced MRI (MEMRI) in mice using a 3T clinical scanner

et al. 2010

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“…MRI has been widely used to measure myocardial mass, end-systolic and end-diastolic volumes, and ejection fraction and has gained clinical acceptance in these applications (4). In addition to measurement of global function by cine MRI, cardiac tagging allows accurate quantification of regional myocardial strain with transmural resolution (5). MR tagging uses spatial modulation of magnetization (SPAMM) (6) or complementary SPAMM (C-SPAMM) (7), to impose stripes or grids (''tags'') of saturated spins in tissue.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of complementary spatial modulation of magnetization tagging in the rat heart after manganese injection

et al. 2007

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It has been shown that manganese-enhanced MRI (MEMRI) can safely depict the myocardial area at risk in models of coronary occlusion-reperfusion for at least 2 h after reperfusion. To achieve this, a solution of MnCl(2) is injected during coronary occlusion. In this model, the regional function quantification deficit of the stunning phase cannot be assessed before contrast injection using MR tagging. The relaxation effects of manganese (which remains in normal cardiac myocytes for several hours) may alter the tags by increasing tag fading and hence the quality of strain measurement. Therefore, we evaluated the feasibility of cardiac MR tagging after manganese injection in normal rats. Six normal Sprague-Dawley rats were imaged in vivo using complementary spatial modulation of magnetization (C-SPAMM) at 1.5 T, before and 15 min after intraperitoneal injection of MnCl(2) solution (~17.5 micromol kg(-1)). The contrast-to-noise ratio of the tag pattern increased significantly (P < 0.001) after injection and remained comparable to the control scan in spite of the higher myocardial relaxation rate caused by the presence of manganese. The measurements of circumferential strain obtained from harmonic phase imaging analysis of the tagged images after MnCl(2) injection did not differ significantly from the measurements before injection in the endocardial, mid-wall, and epicardial regions. In particular, the transmural strain gradient was preserved. Thus, our study suggests that MR tagging could be used in combination with MEMRI to study the acute phase of coronary artery disease.

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“…In quite a few ventricular myocardial disorders, diastolic relaxation seems to reveal more information than systolic contraction, among them hypertrophy due to hypertension or aortic stenosis [12][13][14] or re-modelled myocardium after myocardial infarction [15]. The mere assessment of systolic contraction for the observation of local wall motion abnormalities in clinical routine may soon be supplemented with information on global changes of the contraction pattern in systole as well as in diastole, possibly even with pharmacological stress, derived from automatic postprocessing of tagged images [16][17][18]. Earlier studies have already shown that even in myocardial infarction with a regionally confined lesion the contraction changes affect the whole left ventricle [19,20].…”

Section: Discussionmentioning

confidence: 99%

Myocardial tagging with steady state free precession techniques and semi-automatic postprocessing—impact on diagnostic value

et al. 2007

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Our aim was to determine the diagnostic value of myocardial tagging sequences with regard to the evaluable share of the cardiac cycle. Thirty-three patients were examined at 1.5 T using tagging sequences with gradient-echo (GRE) readout, 18 patients at 1.5 T with steady-state free precession (SSFP), and 11 patients at 3 T using GRE. Two observers graded image quality and determined the share of the cardiac cycle for which postprocessing could be performed (1, optimal; 2, little interaction; 3, whole cycle assessable; 4, diastole non-assessable; 5, systole incomplete; 6, non-diagnostic). With GRE at 1.5 T, median image quality was 4.0 (95% CI 4.0-5.0), while it was significantly better with 2.0 (2.0-3.0) using the SSFP technique and similar at 3 T with 2.9 (1.7-3.5). With GRE at 1.5 T, systole could be assessed in 69% of patients, and an evaluation of the whole cardiac cycle was not possible. With the SSFP sequence at 1.5 T and GRE at 3 T, an evaluation of the whole cardiac cycle was possible in 71% and 70% of the patients, respectively, and systole was assessable in all patients. Tagging sequences with SSFP readout at 1.5 T make a semi-automatic evaluation of the whole cardiac cycle feasible in a large share of patients.

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Comparison between tagged MRI and standard cine MRI for evaluation of left ventricular ejection fraction

Cited by 19 publications

References 16 publications

Myocardial infarction quantification with Manganese‐Enhanced MRI (MEMRI) in mice using a 3T clinical scanner

Myocardial infarction quantification with Manganese‐Enhanced MRI (MEMRI) in mice using a 3T clinical scanner

Feasibility of complementary spatial modulation of magnetization tagging in the rat heart after manganese injection

Myocardial tagging with steady state free precession techniques and semi-automatic postprocessing—impact on diagnostic value

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