Comparison Between Surgical Resection and Stereotactic Radiosurgery in Patients with a Single Brain Metastasis from Non–Small Cell Lung Cancer

Bougie, Emilie; Masson-Côté, Laurence; Mathieu, David

doi:10.1016/j.wneu.2015.01.029

Cited by 34 publications

(20 citation statements)

References 22 publications

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“…One-year OS in that cohort was 62% (19). Stereotactic radiosurgery (SRS) has also been shown to be safe and effective in control of intracranial disease when combined with local treatment of primary tumor (20)(21)(22). A small five-person prospective study in China of patients with synchronous solitary bone metastasis and primary NSCLC showed that simultaneous bone metastatectomy and lung cancer resection followed by chemotherapy was safe; no post-operative complications were seen.…”

Section: Resultsmentioning

confidence: 99%

Prognostic significance of sites of extrathoracic metastasis in patients with non-small cell lung cancer

Bates

Milano

2017

J. Thorac. Dis.

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Section: Resultsmentioning

confidence: 99%

Prognostic significance of sites of extrathoracic metastasis in patients with non-small cell lung cancer

Bates

Milano

2017

J. Thorac. Dis.

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“…20,21 Two session SRS can also be used for these large lesions ( Figure 2). Recent reports of two session SRS delivering a median of 14 (range 10-18 Gy) Gy 3-4 weeks apart for a total of 28 Gy (range [20][21][22][23][24][25][26][27][28][29][30] suggest that this may prove to be a viable option for patients with particularly challenging large lesions. 22,23 SRS as upfront monotherapy can lead to excellent local control.…”

Section: Overview Of Current Treatmentsmentioning

confidence: 99%

“…For non-small lung cancer, the most common cancer to metastasize to the brain, local control rates have varied from 50-94% in variable patient series. [24][25][26][27] The dose of SRS is correlated to local control rates and overall survival. The 20Gy dose leads to improved outcome in comparison to [16][17][18].5Gy when treating brain metastatic lesions in breast cancer patients.…”

Section: Overview Of Current Treatmentsmentioning

confidence: 99%

“…In Bougie et al's series, aggressive management of the primary lung tumor was associated with prolonging survival. 24 Novel systemic therapies have been one of the main contributing factors to increased overall survival for patients with metastatic cancer. 67 Cochran et al demonstrated that patients with brain metastatic renal cell carcinoma who underwent targeted therapy had improved survival in comparison to patients who did not receive targeted therapy.…”

Section: New Frontiers In Decision Makingmentioning

confidence: 99%

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Neurosurgical management of brain metastases

Rodriguez¹,

Tatter²

2015

Current Problems in Cancer

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“…Surgical resection with adjuvant irradiation and stereotactic radiosurgery (SRS) are performed in the treatment of such lesions, Emilie Bougie et al concluded that patients with single BM undergoing surgical resection had a survival advantage [5].…”

Section: Introductionmentioning

confidence: 99%

Cerebral metastasis with 18F-FDG uptake deficiency from non small-cell lung cancer

Wang¹,

Huang²,

Wang³

et al. 2017

Glob Drugs Therap

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A 60-year-old Chinese man was admitted to Hospital with the history of intermittent convulsion of left upper limb with numbness of left lower limb for more than half a month, without headache, dizziness, nausea, vomiting and other symptoms. Brain magnetic resonance imaging (MRI) revealed an occupying lesion in right frontal lobe (Figure 1 A-C), then brain metastasis and gliomas were considered. A chest X-ray was taken, and no abnormality was detected. Tumor markers were slightly higher and results were summarized. Subsequently, he was referred for an FDG PET/CT imaging to evaluate the whole-body, the images revealed a low-density lesion in right frontal lobe with distinct borderline, and FDG uptake was deficient completely, less than that of white matter ( Figure 2). Meanwhile, a solitary pulmonary nodule was detected in upper lobe of the right lung with higher FDG uptake (standardized uptake values (SUVmax: 2.1) (Figure 3), without any other abnormality in other organs. DiscussionLung cancers form a leading cause of death worldwide, of which more than 80% show non-small cell histology [1]. Unfortunately, most lung cancers present at a clinically advanced stage [2,3]. PET/CT is now an important cancer imaging tool, both for diagnosis and staging, as well as offering prognostic information based on response.Because of the high FDG uptake in gray matter, the contrast of the uptake from the tumor versus normal brain tissue decreases, leading to low sensitivity. It is accepted that the correlation of grades with 18 F-FDG showed high-grade brain tumor demonstrated hypermetabolism with high FDG uptake, while low-grade brain tumors revealed low levels of glucose metabolism with less than, equal to, or slightly higher than that of white matter. Cerebral metastases mainly occur in the supratentorial AbstractLung cancers form a leading cause of death worldwide. The prognosis in lung cancer is greatly worsened by the presence of metastases, the brain is an extremely common metastatic site. Non small-cell lung cancer (NSCLC) was more frequently associated with hypermetabolic metastatic brain lesions than small-cell lung cancer (SCLC).18 F-FDG PET/CT is increasingly used in detecting and staging of lung cancer as single "one stop shop" method. However FDG uptake deficiency from NSCLC has not well addressed. Here we presented a particular case of 18 F-FDG PET/CT for cerebral metastasis with 18 F-FDG uptake deficiency from NSCLC.

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Comparison Between Surgical Resection and Stereotactic Radiosurgery in Patients with a Single Brain Metastasis from Non–Small Cell Lung Cancer

Cited by 34 publications

References 22 publications

Prognostic significance of sites of extrathoracic metastasis in patients with non-small cell lung cancer

Prognostic significance of sites of extrathoracic metastasis in patients with non-small cell lung cancer

Neurosurgical management of brain metastases

Cerebral metastasis with 18F-FDG uptake deficiency from non small-cell lung cancer

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