Comparison between right and left ventricular myocardia during the human fetal period. Stereological evaluation

Xavier-Vidal, Ricardo; Madi, Kalil

doi:10.1590/s0066-782x1999000500005

Arq. Bras. Cardiol.

1999

DOI: 10.1590/s0066-782x1999000500005

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Comparison between right and left ventricular myocardia during the human fetal period. Stereological evaluation

Ricardo Xavier-Vidal¹,

Kalil Madi²

Abstract: Purpose -To develop a stereological comparison between right (RV) and left ventricle (LV) myocardium during the third human gestational trimester. Methods

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Cited by 3 publications

References 27 publications

(34 reference statements)

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Myocyte ploidy in heart chambers of birds with different locomotor activity

Anatskaya

Vinogradov

2002

J. Exp. Zool.

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The ploidy levels of atrio- and ventriculocytes were determined by means of cytofluorimetry in 31 species of birds. The obtained data were collated with postnatal growth rate, heart mass index, and relative masses of heart chambers. The difference between mean ploidy of cardiomyocytes in the left and right atrium is small (7.9+/-0.6%) and comparable to the difference in the masses of these chambers (10.5+/-0.8%). The difference between mean ploidy of atrio- and ventriculocytes is most pronounced for the left and right parts of heart (23.9+/-1.4% and 24.0+/-1.3%, respectively) and corresponds to considerable differences in the average masses of atria and ventricles (4.5-fold and 2.1-fold, respectively). The mean cardiomyocyte ploidy levels in the left and right ventricles differ only slightly, as in the case of atria (by 8.1+/-0.5%), whereas the average mass of the left ventricle is greater by 237+/-16%. This discord can be explained by peculiarities of the growth, which is nonproportionally faster in the left ventricle during the last stage of proliferative heart growth as compared to other chambers. The cardiomyocyte ploidy is higher in birds with a relatively small heart and lower ability to flight. Birds with a high locomotor activity in the adult state have an athletic heart (mass index >1%); they are fast growing, altricial species with a low heart workload in the early postnatal ontogenesis. Birds with a low locomotor activity at the adult state are precocial; they grow slowly and have a high locomotor activity from the first minutes of life. Thus, notwithstanding the fact that a greater elevation of cardiomyocyte ploidy level is acquired under a higher functional load (ventricles vs. atria, left vs. right part of the heart), it is associated with a lower functional potential of the organ at the adult state. The level of somatic polyploidy can be considered an indicator of developmental tensions arising due to a high workload during the growth of a given organ and deficiency of resources invested into this growth. J. Exp. Zool. 293:427-441, 2002.

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Myocyte ploidy in heart chambers of birds with different locomotor activity

Anatskaya

Vinogradov

2002

J. Exp. Zool.

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Disector Z-axis mechanical method for stereology

Xavier-Vidal¹

2010

An. Acad. Bras. Ciênc.

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The purpose of this work is to calibrate a not expensive microscope to be applied in Optical Disector estimation. The evaluation of "Z-axis" bias and the "Z-axis" calibration were made utilizing a cover slip and a "manual digimatic outside micrometer scale" (Mitutoyo, Japan). Calibrating the cover slip we performed the calibration of the "Z-axis" of a microscope. In the cover slip two lines were painted with different colors using a pen glass. A blue line was painted on the up surface and another line (red) on the bottom surface of the cover slip forming a cross. Two metal rings with one palette welded in each were adapted in the microscope. Other palette was welded in the gross focuses in order to restrict the route of the fine focuses (Z-axis study) using the two palettes fixed in both rings. Results show that 10 micrometers in "Z-axis" were equal to 3.2 micrometers in the scale of its fine focuses of the microscope. Then, a Disector of 10μm (10μm in Z-axis) is equal to 3.2 micrometers in the fine focuses of this microscope. In conclusion, "Z-axis" calibration is crucial to assure enough precision for Disector Method since the equipment can be manufactured without the ideal precision or its precision can be lost after use.

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Virtual population generator for human cardiomyocytes parameters:in silicodrug cardiotoxicity assessment

Polak

Fijorek

Glinka

et al. 2011

Toxicology Mechanisms and Methods

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To the best of our knowledge, there is no other model available, combining age, cardiomyocyte volume, and area. The main limitations of the proposed models result from the assumptions made at the data analysis stage. The limited amount of information available in the literature and the lack of differentiation between sexes results in one common equation. The developed model is a part of the computational system for drug cardiotoxicity assessment.

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Comparison between right and left ventricular myocardia during the human fetal period. Stereological evaluation

Abstract: Purpose -To develop a stereological comparison between right (RV) and left ventricle (LV) myocardium during the third human gestational trimester. Methods

Cited by 3 publications

References 27 publications

Myocyte ploidy in heart chambers of birds with different locomotor activity

Myocyte ploidy in heart chambers of birds with different locomotor activity

Disector Z-axis mechanical method for stereology

Virtual population generator for human cardiomyocytes parameters:in silicodrug cardiotoxicity assessment

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