Comparison between postoperative TRUS-CT fusion with MRI-CT fusion for postimplant quality assurance in prostate LDR permanent seed brachytherapy

Tisseverasinghe, Steven; Marbán, Marina; Crook, Juanita; Petrik, David; Araujo, Cynthia

doi:10.1016/j.brachy.2021.03.005

Cited by 2 publications

(1 citation statement)

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“…The expense related to this, however, prohibits its routine utilization in clinical practice. Moreover, studies have shown that TRUS and CT could be reasonable alternatives to MR in determining dosimetric parameters [ 35 , 36 ]. From a clinical perspective, it remains controversial whether these parameters related to intraoperative dosimetry could predict or positively correlate with biochemical outcomes after LDR BT.…”

Section: Discussionmentioning

confidence: 99%

Dosimetric outcomes of preoperative treatment planning with intraoperative optimization using stranded seeds in prostate brachytherapy

Lee

Choi³

et al. 2022

PLoS ONE

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This study aimed to evaluate the quality of low-dose-rate (LDR) prostate brachytherapy (BT) based on treatment-related dosimetric outcomes. Data of 100 patients treated using LDR BT with stranded seeds from November 2012 to November 2017 were collected. The prescription dose for the prostate was 145 Gy. The dose constraints for the preoperative plan were: V100% ≥ 95%, V150% ≤ 60%, V200% ≤ 20% for the prostate; V100% for rectum, ≤ 1 cc; and V200 Gy for urethra, 0.0 cc. Intraoperative real-time dose calculation and postoperative dose distribution analysis on days 0 and 30 were performed. Median dosimetric outcomes on days 0 and 30 respective were: V100% 92.28% and 92.23%, V200% 18.63% and 25.02%, and D90% 150.88 Gy and 151.46 Gy for the prostate; V100% for the rectum, 0.11 cc and 0.22 cc; and V200 Gy for the urethra, 0.00 cc and 0.00 cc, respectively. Twenty patients underwent additional seed implantation to compensate for insufficient dose coverage of the prostate. No loss or substantial migration of seeds or severe toxicity was reported. With stranded seed implantation and intraoperative optimization, appropriate dose delivery to the prostate without excessive dose to the organs at risk could be achieved.

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Section: Discussionmentioning

confidence: 99%