Comparison between plethysmometer and micrometer methods to measure acute paw oedema for screening anti-inflammatory activity in mice

Anti-inflammatory activity of extracts and 11,13-dihydrozaluzanin C from Gochnatia polymorpha ssp. floccosa trunk bark in mice

“…The bedding of plethysmometer is the water displacement produced by immersion of the animal paw in the measuring tube inducing a change in the conductance between electrodes. Sharma et al (2004) compared plethysmometer and micrometer methods to measure acute paw oedema for screening anti-inflammatory activity in mice and described and suggested that micrometer method is more sensitive to detect the lowest anti-inflammatory dose of indomethacin when compared with the plethysmometer method (Sharma et al, 2004).…”

Morphometric characterization of murine articular cartilage—Novel application of confocal laser scanning microscopy

“…Paw-swelling is a useful measure in that it allows a nondestructive measure of the inflammation present at the affected joint (Sharma et al, 2004). However, it cannot provide information on whether a reduction in inflammation leads to a concomitant healing of the articular surface.…”

Comparison Between Plethysmometer and Caliper Methods to Monitor Lesion-Size Induced by <i>Leishmania major</i> Infection in BALB/c Mouse Experimental Model

“…However, and as far as we know, only one study suggested that the micrometer method, a method comparable to caliper one, could be more sensitive and useful in measuring paw edema in mice than the plethysmometer method, when used to assess the anti-inflammatory activity [28]. Besides the mice models, a recent study presented a precise, complete and noncontact 3D assessment tool for monitoring the evolution of human cutaneous leishmaniasis wounds based on a 3D laser scanner and computer vision algorithms [29].…”