Comparison Between Plasma Levels of β-Thromboglobulin and Platelet Factor 4 in Various Diseases

Matsuda, Takayuki; Seki, Toshiko; Ogawara, Midori; Miura, Ryuichi; Yokouchi, Masatoshi; Murakami, Hirohisa

doi:10.1055/s-0039-1687208

Cited by 12 publications

(14 citation statements)

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“…As for the interpretation of the results of this study, two facets of the cold pressor tests should be considered: the autonomic function and the response to stress. PF4 is generally accepted as being a biochemical marker of platelet activity in vivo, as is ß-thromboglobulin (BTG) (28,29). The biological half time of these compounds differs.…”

Section: Discussionmentioning

confidence: 99%

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Muscle Contraction Headache and Migraine: Platelet Activation and Plasma Norepinephrine During the Cold Pressor Test

et al. 1989

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For clarification of possible platelet activation in migraine and chronic muscle contraction headache (MCH) under stress, plasma platelet factor 4 (PF4), norepinephrine (NE), and free fatty acids (FFA) were investigated during the cold pressor test. Both PF4 and NE increased significantly, whereas FFA showed no remarkable changes. The increases of PF4 in MCH and migraine during this test were significantly greater than in healthy controls. The increase of PF4, however, was independent of NE increase and FFA changes. On the other hand, we observed decreased NE levels in both MCH and migraine, which might suggest peripheral sympathetic hypofunction. The platelets of MCH or migraine patients seem to be impaired, and the impairment may be caused by continuous sympathetic hypofunction. The behaviour of the above three substances in MCH was similar to that in migraine throughout the present study.

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Section: Discussionmentioning

confidence: 99%

“…The PPP samples were frozen at -70°C until the assay. The PF4 levels in PPP samples were estimated by radioimmunoassay (28,29) using PF4-RIAKIT (Dainabot Co. Ltd., Japan).…”

Section: Methodsmentioning

confidence: 99%

Muscle Contraction Headache and Migraine: Platelet Activation and Plasma Norepinephrine During the Cold Pressor Test

et al. 1989

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“…PF4 is generally accepted as being a biochemical marker of platelet activity in vivo, as is /3-thromboglobulin (BTG) (28,29). On the other hand, the cold pressor test contains some elements of stress.…”

Section: Discussionmentioning

confidence: 99%

“…The PF4 levels in PPP samples were estimated by radioimmunoassay (28,29) using PF4-RIAKIT (Dainabot Co. Ltd., Japan). Normal saline without heparin was slowly infused.…”

Section: Methodsmentioning

confidence: 99%

Muscle Contraction Headache and Migraine: Platelet Activation and Plasma Norepinephrine during the Cold Pressor Test

Takeshima¹,

Takao²,

Urakami³

et al. 1989

Cephalalgia

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“…Increased platelet turnover and decreased platelet survival is usual in patients with DIC; platelet factor 4 levels and beta-thromboglobulin levels are markers of general platelet reactivity and release and are usually elevated in DIC patients. Several reports have suggested that either of these markers may be worthwhile in DIC and for monitoring efficacy of therapy of the intravascular clotting process (149,150). Both assays are readily available for the clinical laboratory, and each has attendant advantages and disadvantages.…”

Section: Molecular Markers For the Diagnosis Of Dicmentioning

confidence: 99%

State-of-the-Art Review : Disseminated Intravascular Coagulation: Objective Criteria for Clinical and Laboratory Diagnosis and Assessment of Therapeutic Response

Bick

1995

Clin Appl Thromb Hemost

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Disseminated intravascular coagulation (DIC) is a confusing disorder from both the diagnostic and therapeutic standpoints. Confusion and controversy stem from the facts that many unrelated diseases can trigger DIC, that there is a lack of uniformity in clinical manifestations and a lack of consensus in the appropriate laboratory diagnosis, and that no agreement exists about specific therapeutic methods. Recommendations for and evaluation of treatment regimens becomes even more difficult because (a) often morbidity and survival are more dependent on the specific cause of DIC and (b) none of the generally used specific therapies, including heparin, antithrombin concentrate, and protein C concentrate, have been subjected to objective prospective randomized trials.One intent of this review is to provide specific and objective guidelines and criteria for the clinical diagnosis, laboratory diagnosis, and assessment of severity of DIC and, most important, to provide an objective system to assess efficacy of any given specific therapy, free from influences of the underlying disease (1). This approach allows for objective decisions regarding diagnosis, treatment, and response to therapy in individual patients. These guidelines also provide objective criteria for prospective randomized trials to assess the safety and efficacy of a specific therapeutic agent for DIC, apart from the morbidity and mortality associated with the underlying disease(s) that induced the DIC process. In developing objective criteria, the rationale for each is briefly presented, including a general review of the etiology, pathophysiology, clinical and laboratory diagnosis, and successful treatment of DIC.

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Comparison Between Plasma Levels of β-Thromboglobulin and Platelet Factor 4 in Various Diseases

Cited by 12 publications

References 0 publications

Muscle Contraction Headache and Migraine: Platelet Activation and Plasma Norepinephrine During the Cold Pressor Test

Muscle Contraction Headache and Migraine: Platelet Activation and Plasma Norepinephrine During the Cold Pressor Test

Muscle Contraction Headache and Migraine: Platelet Activation and Plasma Norepinephrine during the Cold Pressor Test

State-of-the-Art Review : Disseminated Intravascular Coagulation: Objective Criteria for Clinical and Laboratory Diagnosis and Assessment of Therapeutic Response

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