Comparison between plasma concentrations of testosterone, nitric oxide and endothelin 1–2 in penile and brachial venous blood: preliminary results in men with psychogenic impotence

Rossi, Piercarlo; Fabris, Fabrizio; Fiorini, I; Palego, Pierfrancesco; Simi, S.; Rossi, Bruno; Sarteschi, LM; Carpi, Angelo

doi:10.1016/s0753-3322(98)80026-7

Cited by 19 publications

(14 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…14 In the present study, cavernosal levels of ET-1 were not measured in healthy men due to the invasive technique of the procedure, so it is questionable whether levels of ET-1 reported in cavernous body blood of patients with ED were more elevated than in normal men. Previous studies 34,35 reported the absence of any differences between venous and cavernosal levels of ET-1. In our subgroups of organogenic ED men, systemic ET-1 levels were significantly higher than controls and psychogenic patients and also, its cavernosal levels were significantly higher compared to psychogenic ED patients.…”

Section: Vasoactive Mediators and Erectile Dsyfunction E A Hamed Et Almentioning

confidence: 76%

“…The ET-1 upregulation could represent a pathophysiological pathway in diabetic ED or compensatory response to the impaired NO /PGI 2 release which has been reported in diabetic animal models and humans. 35 In this concept, Kadioglu et al 36 reported decline in cavernosal NO levels and elevation of ET-1 levels in arteriogenic ED patients and this may be due to cavernosal damage. In agreement with us, Rossi et al 35 reported no change in ET-1 levels in psychogenic ED patients.…”

Section: Vasoactive Mediators and Erectile Dsyfunction E A Hamed Et Almentioning

confidence: 97%

“…35 In this concept, Kadioglu et al 36 reported decline in cavernosal NO levels and elevation of ET-1 levels in arteriogenic ED patients and this may be due to cavernosal damage. In agreement with us, Rossi et al 35 reported no change in ET-1 levels in psychogenic ED patients. Our results failed to show any correlation between NO and ET-1.…”

Section: Vasoactive Mediators and Erectile Dsyfunction E A Hamed Et Almentioning

confidence: 97%

See 2 more Smart Citations

Role of some vasoactive mediators in patients with erectile dysfunction: their relationship with angiotensin-converting enzyme and growth hormone

et al. 2003

View full text Add to dashboard Cite

The imbalance between vasoconstrictors and vasodilators may play an important role in the pathogenesis of erectile dysfunction (ED). A total of 36 patients with ED, organogenic [diabetic (n ¼ 12) and nondiabetic (n ¼ 12)] and psychogenic (n ¼ 12) etiology, and 12 healthy adult men as controls were included. The levels of endothelin-1 (ET-1), growth hormone (GH), angiotensinconverting enzyme activity (ACE), nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) were determined in the flaccid penis cavernosal blood of patients and in cubital blood of patients and controls. In psychogenic ED, systemic ACE activity was elevated compared to controls (Po0.05). In diabetic and nondiabetic ED patients, systemic levels of ET-1 (Po0.0001 for both) and ACE activity (Po0.01 and o0.05) were higher while GH (Po0.0001 and o0.001), NO (Po0.0001 for both) and cGMP (Po0.01 for both) levels were lower compared to controls. In diabetic patients, systemic and cavernosal ET-1 levels (Po0.0001 for both) and cavernosal ACE activity levels (Po0.05) were significantly elevated while systemic and cavernosal NO (Po0.0001 for both) and GH (o0.001 and o0.05) levels were declined compared to psychogenic. In nondiabetic patients, systemic and cavernosal ET-1 levels (Po0.0001 for both) were significantly elevated while systemic and cavernosal NO (Po0.0001 for both) and systemic GH levels (Po0.05) were declined compared to psychogenic. Systemic NO was positively correlated with GH in psychogenic (r ¼ 0.616, Po0.05), diabetic (r ¼ 0.583, Po0.05) and nondiabetic (r ¼ 0.615, Po0.05) patients and correlated positively with cGMP (r ¼ 0.605, Po0.05) but negatively with ACE activities (r ¼ À0.585, Po0.05) in diabetic patients. In conclusion, plasma levels of ET-1, ACE activities are elevated and associated with reduction of GH, NO and cGMP levels in the systemic and cavernous blood of ED patients. This disturbance may indicate endothelial dysfunction that may hind at their significance in the pathophysiology of ED.

show abstract

Section: Vasoactive Mediators and Erectile Dsyfunction E A Hamed Et Almentioning

confidence: 76%

Section: Vasoactive Mediators and Erectile Dsyfunction E A Hamed Et Almentioning

confidence: 97%

Section: Vasoactive Mediators and Erectile Dsyfunction E A Hamed Et Almentioning

confidence: 97%

See 1 more Smart Citation

Role of some vasoactive mediators in patients with erectile dysfunction: their relationship with angiotensin-converting enzyme and growth hormone

et al. 2003

View full text Add to dashboard Cite

show abstract

“…30,31 Furthermore, detumescence in the healthy penile erection is initiated and mediated by increased a-adrenergic tone which decreases arterial inflow, corporal smooth muscle relaxation and hence venous occlusion, thus allowing blood to drain from the penis. 32 In contrast, in the case of priapism (that is prolonged erection) phenylephrine, an a-adrenoceptor agonist, is often administered intracavernosally to induce There were no significant differences in the number of erections during each 10 min time segment during the 30 min monitoring period. Change in baseline MAP during the last 20 min of the monitoring period was significantly less compared to control in the MXA scenario (*P < 0.05).…”

Section: Discussionmentioning

confidence: 99%

Development of a rat model of sexual performance anxiety: effect of behavioural and pharmacological hyperadrenergic stimulation on APO-induced erections

et al. 2002

View full text Add to dashboard Cite

As part of the multifactorial nature of erectile dysfunction, anxiety associated with sexual performance (SPA) remains a major contributing factor to its progression. In fact, the heightened sympathetic activity associated with sexual performance anxiety may be a key early component of this disruption of normal erectile responses. We are not aware that any animal models have been developed to assess this phenomenon. Using apomorphine (APO, 80 m mg=kg s.c.)-induced erections in rats we characterised the effects of behavioural or pharmacological hyperadrenergic stimulation (that is, anxiety) on erections and hemodynamics. We developed an experimental SPA paradigm by exposing male rats to the stress of being observed by a larger, older male rat placed in close proximity to test rats during APO testing. In a separate group, adrenergic stress was simulated using a sympathomimetic, methoxamine (MXA) given prior to APO testing. In a third group, the changes in circulatory parameters (mean arterial pressure, heart rate) were determined following instrumentation with radiotelemetric transducers for each scenario. APOinduced erections were significantly lower in both the behavioural (1.25 AE 0.8) and pharmacological (0.33 AE 0.5) stressor paradigms compared to controls (2.81 AE 0.9). Further, erections in MXAtreated rats were significantly lower than in the observed scenario. Despite the differences in erections hemodynamic assessments showed no differences in MAP or HR changes between the different experimental conditions. Thus, both the behavioural and pharmacological paradigms of SPA decreased erections, but did not affect the circulation. This suggests that the level of hyperadrenergic input required to induce erectile dysfunction can be subtle, and target only erectogenic pathways.

show abstract

“…Сахарный диабет В последние годы раскрыты механизмы действия андрогенов на эрекцию: обнаружено, что NO-синта-за -фермент, ответственный за синтез оксида азота, является андрогензависимым [45]; у животных с ги-погонадизмом снижена экспрессия NO-синтазы в кавернозных телах, а терапия тестостероном приво дит к восстановлению экспрессии [54]. Дополни тельным указанием на андрогензависимость NO-синтазы является обнаружение рецепторов к андро-генам в нервных клетках тазовых парасимпатичес ких ганглиев, в которых происходит синтез N0 и ВИП [49], а также стимуляция синтеза NO в ганг лиях под влиянием андрогенов [48].…”

Section: общие вопросыunclassified

Erektil'naya disfunktsiya u bol'nykh sakharnym diabetom

Бузиашвили¹

2000

Diabetes mellitus

View full text Add to dashboard Cite

Comparison between plasma concentrations of testosterone, nitric oxide and endothelin 1–2 in penile and brachial venous blood: preliminary results in men with psychogenic impotence

Cited by 19 publications

References 5 publications

Role of some vasoactive mediators in patients with erectile dysfunction: their relationship with angiotensin-converting enzyme and growth hormone

Role of some vasoactive mediators in patients with erectile dysfunction: their relationship with angiotensin-converting enzyme and growth hormone

Development of a rat model of sexual performance anxiety: effect of behavioural and pharmacological hyperadrenergic stimulation on APO-induced erections

Erektil'naya disfunktsiya u bol'nykh sakharnym diabetom

Contact Info

Product

Resources

About